Search results for "Centre"
showing 10 items of 478 documents
Interim 2017/18 influenza seasonal vaccine effectiveness: combined results from five European studies
2018
Between September 2017 and February 2018, influenza A(H1N1)pdm09, A(H3N2) and B viruses (mainly B/Yamagata, not included in 2017/18 trivalent vaccines) co-circulated in Europe. Interim results from five European studies indicate that, in all age groups, 2017/18 influenza vaccine effectiveness was 25 to 52% against any influenza, 55 to 68% against influenza A(H1N1)pdm09, -42 to 7% against influenza A(H3N2) and 36 to 54% against influenza B. 2017/18 influenza vaccine should be promoted where influenza still circulates. Funding: The five studies have received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 634446 to conduct the study in…
Field evaluation of a rapid antigen test (Panbio™ COVID-19 Ag Rapid Test Device) for COVID-19 diagnosis in primary healthcare centres.
2021
Abstract Objectives To our knowledge no previous study has assessed the performance of a rapid antigen diagnostic immunoassay (RAD) conducted at the point of care (POC). We evaluated the Panbio™ COVID-19 Ag Rapid Test Device for diagnosis of coronavirus 2019 disease (COVID-19) in symptomatic patients (n = 412) attending primary healthcare centres. Methods RAD was performed immediately after sampling following the manufacturer's instructions (reading at 15 min). RT-PCRs were carried out within 24 h of specimen collection. Samples displaying discordant results were processed for culture in Vero E6 cells. Presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in cell cultures…
Personalization of regorafenib treatment in metastatic gastrointestinal stromal tumours in real-life clinical practice
2017
Background: Regorafenib (REG) has now been approved as the standard third-line therapy in metastatic gastrointestinal stromal tumour (GIST) patients at the recommended dose and schedule of 160 mg once daily for the first 3 weeks of each 4-week cycle. However, it has a relevant toxicity profile that mainly occurs within the first cycles of therapy, and dose and schedule adjustments are often required to reduce the frequency or severity of adverse events and to avoid early treatment discontinuation. To date, large amounts of data on the use of REG in metastatic GIST patients in daily clinical practice are not available, and we lack information about how this treatment personalization really a…
Ultrafast structural changes within a photosynthetic reaction centre
2021
Nature <London> / Physical science 589, 310 - 314 (2021). doi:10.1038/s41586-020-3000-7
E2F1 interacts with BCL-xL and regulates its subcellular localization dynamics to trigger cell death
2018
International audience; E2F1 is the main pro-apoptotic effector of the pRB-regulated tumor suppressor pathway by promoting the transcription of various pro-apoptotic proteins. We report here that E2F1 partly localizes to mitochondria, where it favors mitochondrial outer membrane permeabilization. E2F1 interacts with BCL-xL independently from its BH3 binding interface and induces a stabilization of BCL-xL at mitochondrial membranes. This prevents efficient control of BCL-xL over its binding partners, in particular over BAK resulting in the induction of cell death. We thus identify a new, non-BH3-binding regulator of BCL-xL localization dynamics that influences its anti-apoptotic activity.
History of Data Centre Development
2012
International audience; Computers are used to solve different problems. For solving these problems computer software and hardware are used, but for operations of those computing facilities a Data Centre is necessary. Therefore, development of the data centre is subordinated to solvable tasks and computing resources. We are studying the history of data centres’ development, taking into consideration an understanding of this. In the beginning of the computer era computers were installed in computing centres, because all computing centres have defined requirements according to whom their operation is intended for. Even though the concept of ‘data centre’ itself has been used since the 1990s, t…
La Sala Parpalló en el Centre Cultural La Beneficència (1995-1999)
2020
During the period 1995-1999, the Sala Parpalló was located in the Beneficència Cultural Center of Valencia, sharing the place with the spaces of the Museum of Prehistory, the Museum of Ethnology and the IVEI. In the investigation it exposed a technical file for each of the 57 self-produced exhibitions carried out in the period and a selection of the studies that accompanied them: the files are displayed chronologically according to the procedures used. The work concludes with the analysis of the objectives that were mainly all the programming: 1) Sala Parpalló as an integrated project; 2) Studies and exhibitions around the Valencian Cultural Imaginary; 3) Analysis of the postmodern crisis; …
Benefits of soil carbon: report on the outcomes of an international scientific committee on problems of the environment rapid assessment workshop
2014
The outcomes of the discussion in the four working sessions showed that although there is an urgent need to improve soil carbon management and stocks, and despite the existing knowledge about good agricultural practices to achieve this goal, these are not put into practice effectively and globally. The apparent contradiction has to do with a mismatch of policies at different societal and geographical scales, and the low policy profile of SOC. All participants agreed in the need to bring SOC into the core of environmental policies at all levels and to improve the governance of policy actions by addressing the stakeholders in a more effective way. Fil: Banwart, Steven. University of Sheffield…
Promoció de la lectura en el marc educatiu
2012
“La promoció de la lectura en el marc educatiu” és un treball de camp que descriu, analitza i planteja uns indicadors d’avaluació d’una experiència realitzada sobre la promoció de la lectura. Aquest treball pretén continuar el camí d’altres investigacions qualitatives que han fixat el seu interés en la lectura, concretament en la lectura a l’aula. L’enfocament qualitatiu que presenta (quasi en la seua totalitat) ve donat per la intenció d’aquesta investigació: la realització d’una recerca molt oberta i flexible que es dirigeix a l’obtenció d’informació, centrada en la pràctica real a l’aula, sobre promoció de la lectura amb l’ús de les tecnologies, atés que el món digital ha irromput amb fo…
Field rules and bias in random surveys with quota samples : an assessment of CIS surveys
2018
Surveys applying quota sampling in their final step are widely used in opinion and market research all over the world. This is also the case in Spain, where the surveys carried out by CIS (a public institution for sociological research supported by the government) have become a point of reference. The rules used by CIS to select individuals within quotas, however, could be improved as they lead to biases in age distributions. Analysing more than 545,000 responses collected in the 220 monthly barometers conducted between 1997 and 2016 by CIS, we compare the empirical distributions of the barometers with the expected distributions from the sample design and/or target populations. Among other …