Search results for "Chains"
showing 10 items of 257 documents
Osimertinib in first-line treatment of advanced EGFR-mutated non-small-cell lung cancer: a cost–effectiveness analysis
2019
Aim: Osimertinib improves progression-free survival in first-line EGFR mutation–positive non-small-cell lung cancer. Materials & methods: A Markov cohort model including costs, utilities and disutilities, was conducted to estimate quality-adjusted life-year (QALY) and incremental cost–effectiveness ratio when treating with osimertinib versus standard first-line tyrosine kinase inhibitors (TKIs). Results: Osimertinib presented higher QALYs (0.61) compared with standard EGFR–TKIs (0.42). Osimertinib costs were €83,258.99, in comparison with €29,209.45 for the standard EGFR–TKIs. An incremental cost–effectiveness ratio of €273,895.36/QALY was obtained for osimertinib. Conclusion: Osimerti…
Theoretical determination of the geometric and electronic structures of oligorylenes and poli(peri‐naphthalene)
1992
We present a theoretical investigation of the electronic structure of oligorylenes (from perylene to heptarylene, including also the naphthalene molecule) and their corresponding polymer poly(peri‐naphthalene) (PPN) using the nonempirical valence effective (VEH) method. The geometry of the unit cell used to generate the polymer is extrapolated from the PM3‐optimized molecular geometries of the longest oligorylenes. That geometry shows some bond alternation along the perimeter carbon chains and a bond length of ≊1.46 Å is calculated for the peri bonds connecting the naphthalene units. The VEH one‐electron energy level distributions calculated for oligorylenes are used to interpret the experi…
Google matrix analysis of worldwide football mercato
2018
[EN] The worldwide football transfer market is analyzed as a directed complex network: the football clubs are the network nodes and the directed edges are weighted by the total amount of money transferred from a club to another. The Google matrix description allows to treat every club independently of their richness and allows to measure for a given club the efficiency of player sales and player acquisitions. The PageRank algorithm, developed initially for the World Wide Web, naturally characterizes the ability of a club to import players. The CheiRank algorithm, also developed to analyze large scale directed complex networks, characterizes the ability of a club to export players. The analy…
LOCHKOVIAN TO PRAGIAN (LOWER DEVONIAN) NERITIC OSTRACODES FROM NIGÜELLA (ZARAGOZA, IBERIAN CHAINS, NE SPAIN)
2021
Lochkovian and Pragian ostracodes from the area of Niguella (Iberian Chains), which is a key area for supra-regional correlation in the Early Devonian, are described for the first time. 12 ostracode taxa from the sections Ni4 and Ni2 could be identified. The silicified ostracodes of Eifelian Ecotype are low in biodiversity, have few individuals, and are comparatively poorly preserved. Characteristic taxa of the Devonian occur. Thus, the faunas show general relations to most European Early Devonian ostracode faunas. Closer relations exist to the Eastern Guadarrama. Polyzygia kroemmelbeini LeFevre & Weyant, 1967 and P. grekoffi Weyant, 1980 are found in the basal Pragian for the first time. B…
A case of Waldenstroem's disease with a monoclonal IgM antiphospholipid antibody
2002
The antiphospholipid syndrome (APS) was described in 1983 as a clinical entity characterized by venous and arterial thrombosis, thrombocytopenia, and recurrent fetal loss. The serological markers of APS are antiphospholipid antibodies (APLA) directed mainly against anionic phospholipids, usually cardiolipin but also phosphatidylserine. Some APLA exhibit lupus anticoagulant activity. Monoclonal gammopathy sometimes occurs with the presence of autoantibodies. In this paper, we describe a patient with the diagnosis of immunocytoma with an IgM, kappa paraprotein with apparent specificity against anionic phospholipids, and lupus anticoagulant activity, but no clinical signs of APS. We describe i…
High sensitivity of free lambda and free kappa light chains for detection of intrathecal immunoglobulin synthesis in cerebrospinal fluid.
2008
Background – So far, an inflammation of the central nervous system (CNS) is diagnosed by immunoglobulin measurement in cerebrospinal fluid (CSF) and serum as well as by determination of the oligoclonal bands. With the free kappa and lambda light chains, new markers to diagnose intrathecal synthesis are available. Methods – In addition to routine diagnostic tests and the assessment of standard parameters, free immunoglobulin light chains were measured in the CSF of patients with neurological disorders. Results – A significant agreement was found between an increase in free kappa light chain CSF serum quotients and results of the currently widely applied method of oligoclonal band measurem…
Primary plasmacytoma of the skin.
1996
Primary plasmacytoma of the skin without evidence of bone marrow plasmacytosis is a rare disorder belonging to the heterogenous spectrum of plasma cell neoplasms. With immunohistochemical techniques, differentiation from benign plasma cell aggregates can be accomplished by demonstrating the monoclonality of tumor cells. We describe a patient in whom a solitary primary cutaneous plasmacytoma developed on the left thigh. Immunohistochemically, plasma cells showed restriction of immunoglobulin lambda-chain expression. Underlying multiple myeloma was excluded by serum protein and immunoglobulin electrophoresis, roentgenographic skeletal survey, and bone marrow biopsy. The tumor responded well t…
Hepatitis C virus prevalence and level of intervention required to achieve the WHO targets for elimination in the European Union by 2030: a modelling…
2017
Background Hepatitis C virus (HCV) is a leading cause of liver-related morbidity and mortality worldwide. In the European Union (EU), treatment and cure of HCV with direct-acting antiviral therapies began in 2014. WHO targets are to achieve a 65% reduction in liver-related deaths, a 90% reduction of new viral hepatitis infections, and 90% of patients with viral hepatitis infections being diagnosed by 2030. This study assessed the prevalence of HCV in the EU and the level of intervention required to achieve WHO targets for HCV elimination. Methods We populated country Markov models for the 28 EU countries through a literature search of PubMed and Embase between Jan 1, 2000, and March 31, 201…
Multipartite entanglement transfer in spin chains
2020
We investigate the transfer of genuine multipartite entanglement across a spin-1/2 chain with nearest-neighbor XX-type interaction. We focus on the perturbative regime, where a block of spins is weakly coupled at each edge of a quantum wire, embodying the role of a multiqubit sender and receiver, respectively. We find that high-quality multipartite entanglement transfer is achieved at the same time that three excitations are transferred to the opposite edge of the chain. Moreover, we find that both a finite concurrence and tripartite negativity is attained at much shorter time, making GHZ-distillation protocols feasible. Finally, we investigate the robustness of our protocol with respect to…
Spin chains for two-qubit teleportation
2019
Generating high-quality multi-particle entanglement between communicating parties is the primary resource in quantum teleportation protocols. To this aim, we show that the natural dynamics of a single spin chain is able to sustain the generation of two pairs of Bell states - possibly shared between a sender and a distant receiver - which can in turn enable two-qubit teleportation. In particular, we address a spin-1/2 chain with XX interactions, connecting two pairs of spins located at its boundaries, playing the roles of sender and receiver. In the regime where both end pairs are weakly coupled to the spin chain, it is possible to generate at predefinite times a state that has vanishing inf…