Search results for "Chinese"

Cisplatin-induced endoreduplication in CHO cells: DNA damage and inhibition of topoisomerase II.

2006

It has been proposed that polyploid cells that arise during a variety of pathological conditions and as a result of exposure to genotoxicants, typically in the liver, become aneuploid through genetic instability. Aneuploidy contributes to, or even drives, tumour development. We have assessed the capacity of the drug cisplatin, one of the most commonly used compounds for the treatment of malignancies, to induce endoreduplication, a particular type of polyploidy, in cultured Chinese hamster AA8 cells. Taking into account that any interference with DNA topoisomerase II (topo II) function leads to endoreduplication, we have found that treatment of the cells with this platinum compound results i…

Genomic instability induced by α-pinene in Chinese hamster cell line.

2012

Here, we report the effects of exposure of mammalian cells to α-pinene, a bicyclic monoterpene used in insecticides, solvents and perfumes. Morphological analysis, performed in V79-Cl3 cells exposed for 1 h to increasing concentrations (25 up to 50 μM) of α-pinene, indicated a statistically significant increase in micronucleated and multinucleated cell frequencies; apoptotic cells were seen at 40 and 50 μM. This monoterpene caused genomic instability by interfering with mitotic process; in fact, 50% of cells (versus 19% of control cells) showed irregular mitosis with multipolar or incorrectly localised spindles. Cytogenetic analysis demonstrated high-frequency hypodiploid metaphases as well…

Ķīna un ķīniešu migrācija ārzemēs

2019

Migrācija kā viena no globalizācijas procesa izpausmēm ir kļuvusi par nozīmīgu parādību divdesmitajā gadsimtā. Ta ietekmē dažādu pasaules valstu politisko, sociālekonomisko un demogrāfisko attīstību, starpvalstu mijiedarbības un integrācijas procesus starptautiskajā sabiedrībā. Tajā pašā laikā migrācijas pieaugums izraisa drošības un noziedzības problēmu pasliktināšanas nelegālās migrācijas, cilvēku tirdzniecības, ksenofobijas un terorisma veidā. Tas viss pievērš lielu uzmanību starptautiskajām organizācijām, valstu valdībām, zinātnieku aprindām un plašai sabiedrībai. Ķīnas migrācijai kā nozīmīgai demogrāfiskajai parādībai ir ietekme uz saņēmējvalstīm, ieviešot izmaiņas dzimumu un demogrāfi…

Evaluation and management of hemorrhoids: Italian society of colorectal surgery (SICCR) consensus statement

2015

Hemorrhoids are one of the most common medical and surgical diseases and the main reason for a visit to a coloproctologist. This consensus statement was drawn up by the Italian society of colorectal surgery in order to provide practice parameters for an accurate assessment of the disease and consequent appropriate treatment. The authors made a careful search in the main databases (MEDLINE, PubMed, Embase and Cochrane), and all results were classified on the basis of the grade of recommendation (A-C) of the American College of Chest Physicians.

The mixed general routing polyhedron

2003

[EN] In Arc Routing Problems, ARPs, the aim is to find on a graph a minimum cost traversal satisfying some conditions related to the links of the graph. Due to restrictions to traverse some streets in a specified way, most applications of ARPs must be modeled with a mixed graph. Although several exact algorithms have been proposed, no polyhedral investigations have been done for ARPs on a mixed graph. In this paper we deal with the Mixed General Routing Problem which consists of finding a minimum cost traversal of a given link subset and a given vertex subset of a mixed graph. A formulation is given that uses only one variable for each link (edge or arc) of the graph. Some properties of the…

The Leader–Member Exchange Theory in the Chinese Context and the Ethical Challenge of Guanxi

2013

The leader–member relationship has been identified as a key determinant of successful working relationships and business outcomes in China. A high-quality leader–member relationship helps managers and employees to meet the demands they face and gives them the opportunity to develop socially, emotionally and morally. Such relationships form the basis of the overall well-being and success of the organisation. This article contributes to relationally oriented leadership theories and more specifically to the leader–member exchange (LMX) theory by examining the theory in the context of Western expatriate managers and Chinese employees in China. The first aim of the study is to analyse the simila…

Analytical Performance and Validation of a Bioassay for Thyroid-Blocking Antibodies

2016

A cell-based bioassay for the measurement of thyroid blocking autoantibodies (TBAb) has been recently reported. The analytical performance and validation of this bioassay is assessed and described.Chinese hamster ovary cells expressing a chimeric thyrotropin receptor were treated with bovine (b) TSH and different concentrations of an immunoglobulin G (IgG) monoclonal human TBAb (K1-70). TBAb was measured as a function of luciferase activity relative to bTSH alone and expressed as percent inhibition. Results obtained in the chimeric cell line were compared with those of a wild-type cell line. Analytical performance studies were subsequently performed with the chimeric cell line only.Immunode…

Enhanced extraction of astragalosides from Radix Astragali by negative pressure cavitation-accelerated enzyme pretreatment.

2010

The optimal conditions for extraction of astragalosides III and IV (AGs III and IV) in Radix Astragali by negative pressure cavitation-accelerated enzyme pretreatment were studied on the basis of a Box-Behnken design and response surface methodology. Experimental results showed that negative pressure, amount of enzyme and incubation temperature were the main factors governing the enzyme pretreatment of Radix Astragali. The optimum parameters were obtained as follows: negative pressure -0.08 Mpa, amount of enzyme 1.48% (w/w of materials) and incubation temperature 45 degrees C. Under the optimal conditions, the maximal extraction yields of AGs III and IV were 0.103 and 0.325 mg/g, which were…

European and Chinese Cognitive Styles and their impact on Teaching/Learning Mathematics

2010

Processing and representation of ambiguous words in Chinese reading: Evidence from eye movements

2016

In the current study, we used eye tracking to investigate whether senses of polysemous words and meanings of homonymous words are represented and processed similarly or differently in Chinese reading. Readers read sentences containing target words which was either homonymous words or polysemous words. The contexts of text preceding the target words were manipulated to bias the participants toward reading the ambiguous words according to their dominant, subordinate, or neutral meanings. Similarly, disambiguating regions following the target words were also manipulated to favor either the dominant or subordinate meanings of ambiguous words. The results showed that there were similar eye movem…