Search results for "Chinese"

Pharmacological Properties of Shikonin – A Review of Literature since 2002

2013

The naphthoquinone shikonin is the main active principle of Zicao, a traditional Chinese herbal medicine made from the dried root of Lithospermum erythrorhizon. Studies carried out over the past 30 years have provided a scientific basis for the use of Zicao which has been long employed in folk medicine to treat a variety of inflammatory and infectious diseases. In particular, shikonin has been shown to possess many diverse properties, including antioxidant, anti-inflammatory, antithrombotic, antimicrobial, and wound healing effects. The fact that shikonin shows so many beneficial properties has increased the interest in this molecule dramatically, especially in the past few years. The aim o…

The DNA methylation inhibitor 5-azacytidine modulates 6-thioguanine toxicity in mammalian cells

2003

In order to assess the effects of combining two antimetabolites used separately to treat human leukemias, we carried out an experimental study by exposing V79 Chinese hamster cells, a 6-thioguanine (6-tG)-sensitive cell line, to sequential and concurrent treatments with 5-azacytidine (5-azaC) and 6-tG. In this paper, we demonstrate that there is a clear dependency for the way in which this combination was tested. Pre-treatment with 5-azaC made V79 cells more resistant to 6-tG by a substantial reduction in 6-tG incorporation into DNA; this effect could still be detected for several cell divisions after the removal of 5-azaC, and was achieved neither by reduced cell growth nor by the inductio…

Effect of polyphenols on enniatins-induced cytotoxic effects in mammalian cells

2012

Enniatins (ENs) are fungal secondary metabolites produced by genus Fusarium. The ENs exert antimicrobial and insecticidal effect, and has also been demonstrated cytotoxic effects on several mammalian cell lines. On the other hands, it has been proved that natural polyphenols have antioxidant effect. In this study, cell effects at low levels of exposure of four ENs (A, A(1), B and B(1)) and five polyphenols (quercetin, quercetin-3-β-D-glucoside, rutin, myricetin and t-pterostilbene) present in wine; and the cytoprotective effect of these polyphenols exposed simultaneously with ENs in Chinese Hamster Ovary (CHO-K1) cells, were studied. Cell effects were determined by the MTT test after 24 h o…

Antologia di racconti postmaoisti (1977-1981)

2017

Il volume, corredato da una prefazione del Prof. Paolo Santangelo, comprende una lunga introduzione sullo sviluppo della letteratura cinese contemporanea incentrata sul racconto, e propone, nella traduzione italiana dell'Autrice stessa dall'originale in cinese, dodici racconti scritti fra il 1977 e il 1981. The volume includes a preface written by Prof. Paolo Santangelo, a long introduction to the contemporary Chinese literature based on the short story, and the translations by the Author herself into Italian from the original in Chinese of twelve short stories written between 1977 and 1981.

Vascular Activity of (-)-Anonaine, (-)-Roemerine and (-)-Pukateine, Three Natural 6a(R)-1,2-Methylenedioxyaporphines with Different Affinities for α1…

2004

We have studied the mechanism of action of three 6a( R)-1,2-methylenedioxyaporphines as vasorelaxant compounds. The alkaloids assayed showed different affinities for the three human cloned alpha (1)-adrenoceptor (AR) subtypes stably expressed in rat-1 fibroblasts, showing lower affinity for alpha(1B)-AR with regard to the alpha(1A)- or alpha(1D)-subtypes. These three natural compounds are more potent inhibitors of [ (3)H]-prazosin binding than of [ (3)H]-diltiazem binding to rat cerebral cortical membranes. As all these alkaloids inhibited noradrenaline (NA)-induced [ (3)H]-inositol phosphate formation in cerebral cortex and rat tail artery, they may be safely viewed as alpha (1)-AR antagon…

A comparison of two different formulations for Arc Routing Problems on Mixed graphs

2006

[EN] Arc routing problems on mixed graphs have been modelled in the literature either using just one variable per edge or associating to each edge two variables, each one representing its traversal in the corresponding direction. In this paper, and using the mixed general routing problem as an example, we compare theoretical and computationally both formulations as well as the lower bounds obtained from them using Linear Programming based methods. Extensive computational experiments, including some big and newly generated random instances, are presented.

Argumentation and proving: a didactical experience with Chinese and Italian students

2009

Argumentation and Proving in Multicultural Classes: A didactical experience with Chinese and Italian students

2009

Argumentation and proving in multicultural classes: a linguistic-cultural approach with Chinese students

2009

The paper explores, through different theoretical/experimental investigations, a particular complex field of study such as the analysis of the teaching/learning phases in a multicultural setting in class. Through a linguistic-cultural approach it is a further close examination on the didactic thematic related to a possible comparison between East and West and particularly between Chinese mathematical thought and Italian thought, in some particular aspects related to the phase of argumentation and proving. To carry out the research, we chose to investigate, in a qualitative and quantitative way, the behaviour of Chinese and Italian students of different ages (13-15 years old) attending the S…

Early induction of genetic instability and apoptosis by arsenic in cultured Chinese hamster cells

2002

In order to assess at what time from the beginning of exposure inorganic arsenic can give rise to genetic instability and trigger apoptosis, V79-C13 Chinese hamster cells were treated with 10 microM sodium arsenite for 24 h. Under these conditions, cell survival was >70% and cells showed neither an increase in chromosome aberration frequency nor a delay in cell cycle progression. Investigations, which were carried out every 6 h during the treatment, revealed an early appearance of genetically unstable cells, namely micronucleated, multinucleated and mononucleated 'giant' cells, as well as apoptotic cells. Indirect immunostaining using anti-beta-tubulin antibody showed severe alterations in …