Search results for "Chip"
showing 10 items of 386 documents
Design of large scale sensors in 180 nm CMOS process modified for radiation tolerance
2019
International audience; The last couple of years have seen the development of Depleted Monolithic Active Pixel Sensors (DMAPS) fabricated with a process modification to increase the radiation tolerance. Two large scale prototypes, Monopix with a column drain synchronous readout, and MALTA with a novel asynchronous architecture, have been fully tested and characterized both in the laboratory and in test beams. This showed that certain aspects have to be improved such as charge collection after irradiation and the output data rate. Some improvements resulting from extensive TCAD simulations were verified on a small test chip, Mini-MALTA. A detailed cluster analysis, using data from laboratory…
The MuPix System-on-Chip for the Mu3e Experiment
2016
Nuclear instruments & methods in physics research / A 845, 194 - 198 (2016). doi:10.1016/j.nima.2016.06.095
Performance of the front-end electronics of the ANTARES neutrino telescope
2010
ANTARES is a high-energy neutrino telescope installed in the Mediterranean Sea at a depth of 2475 m. It consists of a three-dimensional array of optical modules, each containing a large photomultiplier tube. A total of 2700 front-end ASICs named Analogue Ring Samplers (ARS) process the phototube signals, measure their arrival time, amplitude and shape as well as perform monitoring and calibration tasks. The ARS chip processes the analogue signals from the optical modules and converts information into digital data. All the information is transmitted to shore through further multiplexing electronics and an optical link. This paper describes the performance of the ARS chip; results from the fu…
Studies for low mass, large area monolithic silicon pixel detector modules using the MALTA CMOS pixel chip
2021
Abstract The MALTA monolithic silicon pixel sensors have been used to study dicing and thinning of monolithic silicon pixel detectors for large area and low mass modules. Dicing as close as possible to the active circuitry will allow to build modules with very narrow inactive regions between the sensors. Inactive edge regions of less than 5 μ m to the electronic circuitry could be achieved for 100 μ m thick sensors. The MALTA chip (Cardella et al., 2019) also offers the possibility to transfer data and power directly from chip to chip. Tests have been carried out connecting two MALTA chips directly using ultrasonic wedge wire bonding. Results from lab tests show that the data accumulated in…
COMPASS—A COMPAct decay spectroscopy set-up
2018
Abstract A compact silicon detector array with high spatial granularity and fast, fully digital data recording has been developed and commissioned for the investigation of heavy and superheavy nuclear species. The detector array can be combined in close geometry with large volume germanium detectors. It offers comprehensive particle and photon coincidence and correlation spectroscopy by highly efficient evaporation residue, α , γ , conversion electron and X-ray detection supported by the high granularity of the implantation chip. Access to fast decay events in the sub-microsecond region is made possible by the fast timing properties of the digital signal processing. A novel Si-chip support …
L’idea di iperspazio e l’evoluzione del pensiero geometrico al quadridimensionale
Attraverso un viaggio storico di quasi due secoli, lo scritto vuole analizzare le situazioni in cui lo studio della geometria iperdimensionale ha avuto la sua genesi e la sua evoluzione. Colui il quale approfondisce in modo analitico la questione è Ludwig Schläfli che con il suo Theorie der vielfachen Kontinuität, a partire dallo studio di un integrale, analizza lo spazio pluridimensionale senza cercare una immagine nel mondo circostante di ciò che descrive in modo molto sistematico attraverso i coefficienti che prendono il suo nome. L’aspetto divulgativo della questione viene affrontata a partire dagli anni ’70 del XIX secolo da Beltrami, Casorati e Stringham, da un punto di vista merament…
Plasma circulating miRNAs as diagnostic and prognostic biomarkers in alpha-1 antitrypsin deficiency
2019
Introduction: Alpha-1 antitrypsin (AATD) deficiency is an inherited condition that leads to decreased circulating AAT levels, significantly increasing the risk of lung and liver disease. AATD is underdiagnosed. Severity of symptoms in AATD patients are highly variable and neither protein levels nor phenotype are sufficient to identify which patients will develop lung and/or liver disease. Therefore, new strategies and biomarkers for early diagnosis and prognosis of the disease are needed. Rationale and Aims: MicroRNAs (miRNAs) regulate gene expression and have been associated with the pathogenesis of various lung and liver diseases. Circulating miRNAs may serve as diagnostic and prognostic …
Two independent epigenetic biomarkers predict survival in neuroblastoma.
2015
Background Neuroblastoma (NB) is the most common extracranial pediatric solid tumor with a highly variable clinical course, ranging from spontaneous regression to life-threatening disease. Survival rates for high-risk NB patients remain disappointingly low despite multimodal treatment. Thus, there is an urgent clinical need for additional biomarkers to improve risk stratification, treatment management, and survival rates in children with aggressive NB. Results Using gene promoter methylation analysis in 48 neuroblastoma tumors with microarray technology, we found a strong association between survival and gene promoter hypermethylation (P = 0.036). Hypermethylation of 70 genes significantly …
Comparison of genetic risk prediction models to improve prediction of coronary heart disease in two large cohorts of the MONICA/KORA study
2021
Abstract It is still unclear how genetic information, provided as single‐nucleotide polymorphisms (SNPs), can be most effectively integrated into risk prediction models for coronary heart disease (CHD) to add significant predictive value beyond clinical risk models. For the present study, a population‐based case‐cohort was used as a trainingset (451 incident cases, 1488 noncases) and an independent cohort as testset (160 incident cases, 2749 noncases). The following strategies to quantify genetic information were compared: A weighted genetic risk score including Metabochip SNPs associated with CHD in the literature (GRSMetabo); selection of the most predictive SNPs among these literature‐co…
TLMCO-simulation for an open source MPSOC platform under STARSoC environment
2008
In the last decade, the embedded systems become more and more complex. This complexity is due to the fact that these systems contain more heterogeneous hardware and software components (CPUpsilas, DSP, IP, etc.). Such systems called multiprocessor-on-chip (MPSoC) require new design approaches in order to satisfy several constraints, verification time, cost and time to market.