Search results for "Chiral"

Determination of the enantiomeric composition of amphetamine, methamphetamine and 3,4-methylendioxy-N-methylamphetamine (MDMA) in seized street drug …

2021

Amphetamine (speed), methamphetamine (crystal meth), and 3,4-methylenedioxy-N-methylamphetamine (MDMA, ecstasy) represent the most frequently abused amphetamine-type stimulants (ATS). Differences in pharmacological potency and metabolism have been shown for the enantiomers of all three stimulants. Legal consequences in cases of drug possession may also differ according to the German law depending on the enantiomeric composition of the seized drug. Therefore, enantioselective monitoring of seized specimens is crucial for legal and forensic casework. Various kinds of samples of amphetamine (n = 143), MDMA (n = 94), and methamphetamine (n = 528) that were seized in southern Germany in 2019 and…

The embodiment of wastewater data for the estimation of illicit drug consumption in Spain

2021

Data obtained from wastewater analysis can provide rapid and complementary insights in illicit drug consumption at community level. Within Europe, Spain is an important country of transit of both cocaine and cannabis. The quantity of seized drugs and prevalence of their use rank Spain at the top of Europe. Hence, the implementation of a wastewater monitoring program at national level would help to get better understanding of spatial differences and trends in use of illicit drugs. In this study, a national wastewater campaign was performed for the first time to get more insight on the consumption of illicit drugs within Spain. The 13 Spanish cities monitored cover approximately 6 million inh…

Stereoisomeric profiling of drugs of abuse and pharmaceuticals in wastewaters of Valencia (Spain)

2014

AbstractThe enantiomeric and diastereomeric profiling of chiral pharmaceuticals (ephedrine, norephedrine, atenolol and venlafaxine) and illicit drugs (amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxy-N-methylamphetamine (MDMA) and 3,4-methylenedioxy-N-ethylamphetamine (MDEA)) was undertaken over a period of fourteen consecutive days in three wastewater treatment plants (WWTPs) in the city of Valencia, Spain. Degradation efficiency of WWTPs was found to be compound and enantiomer dependent. Selective enantiomer enrichment was observed for several target analytes. Amphetamine and MDMA were enriched with R(−)-enantiomers. 1S,2S(+)-pseudoephedrine was found …

Study of eta K(K)over-bar and eta ' K(K)over-bar with the fixed center approximation to Faddeev equations

2013

In the present work we investigate the three-body systems of eta K (K) over bar and eta'K (K) over bar, by taking the fixed center approximation to Faddeev equations. We find a clear and stable resonance structure around 1490 MeV in the squared eta K (K) over bar scattering amplitude, which is not sensitive to the renormalization parameters. Conversely, we get only an enhancement effect of the threshold in the eta'K (K) over bar amplitude that indicates the difficulty to bind the eta'K (K) over bar system as a consequence of the eta'K interaction being weaker than the eta K one. We associate the eta K (K) over bar state found to the eta(1475).

Compton scattering by a pion and off-shell effects

1994

We consider Compton scattering by a pion in the framework of chiral perturbation theory. We investigate off--shell effects in the s-- and u--channel pole diagrams. For that purpose we perform a field transformation which, in comparison with the standard Gasser and Leutwyler Lagrangian, generates additional terms at order $p^4$ proportional to the lowest--order equation of motion. As a result of the equivalence theorem the two Lagrangians predict the same Compton scattering S--matrix even though they generate different off--shell form factors. We conclude that off--shell effects are not only model--dependent but also representation--dependent.

πNscattering in relativistic baryon chiral perturbation theory reexamined

2011

We have analyzed pion-nucleon scattering using the manifestly relativistic covariant framework of infrared regularization up to $\mathcal{O}({q}^{3})$ in the chiral expansion, where $q$ is a generic small momentum. We describe the low-energy phase shifts with a similar quality as previously achieved with heavy baryon chiral perturbation theory, $\sqrt{s}\ensuremath{\lesssim}1.14$ GeV. New values are provided for the $\mathcal{O}({q}^{2})$ and $\mathcal{O}({q}^{3})$ low-energy constants, which are compared with previous determinations. This is also the case for the scattering lengths and volumes. Finally, we have unitarized the previous amplitudes and as a result the energy range where data …

Measurements of the Generalized Electric and Magnetic Polarizabilities of the Proton at LowQ2Using the Virtual-Compton-Scattering Reaction

2006

Experimental details of a virtual Compton scattering (VCS) experiment performed on the proton at the MIT-Bates out-of-plane scattering facility are presented. The VCS response functions ${P}_{LL}\ensuremath{-}{P}_{TT}/\phantom{{P}_{TT}\ensuremath{\varepsilon}}\ensuremath{\varepsilon}$ and ${P}_{LT}$ have been measured at ${Q}^{2}=0.057\phantom{\rule{0.28em}{0ex}}{\mathrm{GeV}}^{2}/{c}^{2}$. The generalized electric and magnetic polarizabilities, $\ensuremath{\alpha}({Q}^{2})$ and $\ensuremath{\beta}({Q}^{2})$, and the mean-square electric polarizability radius$\ensuremath{\langle}{r}_{\ensuremath{\alpha}}^{2}\ensuremath{\rangle}$ are obtained from a dispersion analysis of the data. The resu…

Aggregati supramolecolari di tensioattivi in fase gassosa: formazione e solubilizzazione di aminoacidi

Enantiomerization of an inherently chiral resorcarene derivative: determination of the interconversion barrier by computer simulation of the dynamic …

2001

Abstract The inherently chiral tetrabenzoxazine resorcarene derivative 1 shows characteristic plateau-formation during enantioselective HPLC separation on the chiral stationary phase Chiralpak AD. By computer assisted peak form analysis of the elution profiles, obtained from temperature dependent dynamic HPLC (DHPLC) experiments, with ChromWin, the enantiomerization barrier Δ G # (298 K)=92±2 kJ mol −1 and the activation parameters Δ H # =53.0±1.8 kJ mol −1 and Δ S # =−131±14 J (K mol) −1 were determined.

Enantioselective synthesis and absolute configurations of aculeatins A, B, D, and 6-epi-aculeatin D

2006

The three naturally occurring, bioactive spiroacetals aculeatins A, B, and D, as well as the non-natural 6-epi-aculeatin D have been synthesized for the first time in enantiopure form using an asymmetric allylation as the only chirality source. A further key step was a stereoselective aldol reaction with remote induction. The absolute configurations of the natural products have been established and an erroneous structural assignment has been corrected.