Search results for "Cholesterol"
showing 10 items of 1211 documents
Treatment of primary hypercholesterolemia: comparison of the effectiveness of different statins
2000
Nelipīdu riska faktoru izvērtējums pacientiem ar ģimenes hiperholesterolēmiju
2018
Pamatojums: Ģimenes Hiperholesterinēmija (ĢH) raksturojas ar paaugstinātu zema blīvuma lipoproteīnu holesterīna (ZBL-H) koncentrāciju, kas ievērojami paaugstina agrīnu kardiovaskulāro slimību (KVS) attīstības risku. Papildus (ZBL-H) citu, ar lipīdiem nesaistītu, riska faktoru nozīmīgai ietekmei uz KVS attīstības risku, ir svarīga to identifikācija un kontrole jau dzīves laikā vai kopš bērnības. Mērķis: Raksturot un identificēt biežākos ar lipīdiem nesaistītus riska faktorus, kas var veicināt KVS attīstību pacientiem ar ĢH, kas tādējādi varētu palīdzēt akcentēt nozīmi to turpmākai kontrolei. Materiāli un metodes: Šī ir retrospektīva kohorta analīze pacientu grupai ar ticamu vai drošu ĢH diag…
Mipomersen: a lipid-lowering agent with a novel mechanism of action
2013
“...mipomersen is a ... valuable alternative to apheresis for patients with heterozygous familial hypercholesterolemia.”
Cholesterol protein interaction - the issue of specificity
2009
Clustering-triggered endocytic pathway of α2β1 integrin
2012
Combined Analysis of the Effects of Exposure to Blue Light in Ducks Reveals a Reduction in Cholesterol Accumulation Through Changes in Methionine Met…
2021
Monochromatic light is widely used in industry, medical treatment, and animal husbandry. Green-blue light has been found to stimulate the proliferation of satellite cells and the results of studies on the effects of blue light on poultry vary widely. It would be worthwhile to study the effect of blue light on poultry growth and how exposure to blue light affects metabolism and the intestinal microbiota. In this study, we irradiated Cherry Valley ducks with 460 nm wavelength light (blue light) for 3 weeks to explore the effects of blue light in comparison to those of white light (combined wavelength light) on animal growth and development. Our results showed that, under exposure to blue ligh…
Disturbances in cholesterol, bile acid and glucose metabolism in peroxisomal 3-ketoacylCoA thiolase B deficient mice fed diets containing high or low…
2014
SPE IPM UB; International audience; : The peroxisomal 3-ketoacyl-CoA thiolase B (ThB) catalyzes the thiolytic cleavage of straight chain 3-ketoacyl-CoAs. Up to now, the ability of ThB to interfere with lipid metabolism was studied in mice fed a routinely laboratory chow enriched or not with the synthetic agonist Wy14,643, a pharmacological activator of the nuclear hormone receptor PPARα. The aim of the present study was therefore to determine whether ThB could play a role in obesity and lipid metabolism when mice are chronically fed a synthetic High Fat Diet (HFD) or a Low Fat Diet (LFD) as a control diet. To investigate this possibility, wild-type (WT) mice and mice deficient for Thb (Thb(…
Role of Nutraceuticals in Hypolipidemic Therapy.
2015
Nutraceuticals are food components or active ingredients present in foods and used in therapy. This article analyzes the characteristics of the molecules with a lipid-lowering effect. The different nutraceuticals may have different mechanisms of action: inhibition of cholesterol synthesis primarily through action on the enzyme HMG-CoA reductase (policosanol, polyphenols, garlic and, above all, red yeast rice), increase in LDL receptor activity (berberine), reduction of intestinal cholesterol absorption (garlic, plant sterols, probiotics), and also the ability to interfere with bile metabolism (probiotics, guggul). Based on the different mechanisms of action, some nutraceuticals are then abl…
Menopausal Status and Physical Activity Are Independently Associated With Cardiovascular Risk Factors of Healthy Middle-Aged Women: Cross-Sectional a…
2019
Cardiovascular disease (CVD) is the primary cause of mortality in women in developed countries. CVD risk rises with age, yet for women there is a rapid increase in CVD risk that occurs after the onset of menopause. This observation suggests the presence of factors in the middle-aged women that accelerate the progression of CVD independent of chronological aging. Leisure time physical activity (LTPA) is a well-established protective factor against CVD. However, its role in attenuating atherogenic lipid profile changes and CVD risk in post-menopausal women has not been well-established. The present study is part of the Estrogenic Regulation of Muscle Apoptosis (ERMA) study, a population-based…
Regulation of raft-derived endocytic pathways : studies on echovirus 1 and baculovirus
2009
Elina Kakkonen tutki väitöskirjassaan kahden erilaisen viruksen, echovirus 1:n ja bakuloviruksen soluun sisäänmenon reittejä ja säätelijöitä. Echovirus 1 (EV1) on ihmisiä infektoiva pikornavirus, joka voi aiheuttaa esimerkiksi aivokalvontulehdusta, sydänlihastulehdusta sekä lievempiä hengitystieinfektioita. Bakulovirus puolestaan on ihmisille vaaraton, hyönteisiä infektoiva virus, joka on osoittautunut lupaavaksi geeninsiirtokuljettajaksi geeniterapiassa.Virukset voivat käyttää soluun tunkeutumisessaan hyväkseen soluissa valmiina olevia erilaisia reittejä, joita solut itse tarvitsevat esimerkiksi ravintoaineiden sisäänottoon. Näin virukset pääsevät solun sisälle solun oman koneiston kuljett…