Search results for "Chronic kidney disease."

Position paper on liver and kidney diseases from the Italian Association for the Study of Liver (AISF), in collaboration with the Italian Society of …

2021

Abstract Liver and kidney are strictly connected in a reciprocal manner, in both the physiological and pathological condition. The Italian Association for the Study of Liver, in collaboration with the Italian Society of Nephrology, with this position paper aims to provide an up-to-date overview on the principal relationships between these two important organs. A panel of well-recognized international expert hepatologists and nephrologists identified five relevant topics: 1) The diagnosis of kidney damage in patients with chronic liver disease; 2) Acute kidney injury in liver cirrhosis; 3) Association between chronic liver disease and chronic kidney disease; 4) Kidney damage according to dif…

Large Between-Patient Variability in eGFR Decline before Clinical Trial Enrollment and Impact on Atrasentan’s Efficacy:

2021

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Young woman with Branchio-Oto-Renal Syndrome and a novel mutation in the EYA-1 gene

2011

Branchio-oto-renal (BOR) syndrome is an autosomal dominant disease clinically characterized by the coexistence of some or all of the following major disorders: deafness, cervical branchial fistulae, preauricular pits, and renal abnormalities. Most families with BOR syndrome have mutations on the EYA-1 gene on chromosome 8q. We present the case of a 23-year-old Italian woman without a familial history of BOR syndrome. The patient, who had hearing loss and a history of surgeries for correction of bilateral cervical branchial fistulae and bilateral preauricular pits, presented with renal impairment, hypertension and overt proteinuria. DNA sequencing showed a novel heterozygous mutation 1420-14…

Metalloprotease meprin beta in rat kidney: glomerular localization and differential expression in glomerulonephritis

2008

Meprin (EC 3.4.24.18) is an oligomeric metalloendopeptidase found in microvillar membranes of kidney proximal tubular epithelial cells. Here, we present the first report on the expression of meprin beta in rat glomerular epithelial cells and suggest a potential involvement in experimental glomerular disease. We detected meprin beta in glomeruli of immunostained rat kidney sections on the protein level and by quantitative RT-PCR of laser-capture microdissected glomeruli on the mRNA level. Using immuno-gold staining we identified the membrane of podocyte foot processes as the main site of meprin beta expression. The glomerular meprin beta expression pattern was altered in anti-Thy 1.1 and pas…

Perifērās neiropātijas izmeklēšana hemodialīzes pacientiem

2018

Pamatinformācija: Hroniska nieru slimība (HNS) ir globāla veselības problēma, kuras vidējā izplatība Eiropā ir 18.4 %. Perifērā neiropātija (PN) ir visizplatītākā neiroloģiskā komplikācija (~ 60 līdz 100 %) šiem pacientiem. PN diagnoze ietver padziļinātu klīnisko izmeklēšanu, tai skaitā pacienta slimības vēstures analīzi, neiroloģisko izmeklēšanu, laboratorisko testēšanu un elektrofizioloģiskās izmeklēšanas metodes. Skrīninga metodes var palīdzēt agrīni noteikt PN HNS pacientiem un laicīgi sākt terapiju, mainot slimības attīstības gaitu. Mērķis: Noteikt perifēro neiropātiju HNS pacientiem ar Mičiganas neiropātijas skrīninga metodes (MNSI) palīdzību, kas apstiprināta un pielietota cukura dia…

Relationship between plasma endothelin-1 and aortic stiffness in hypertensive patients with chronic kidney disease

2012

Chronic kidney disease in patients with obstructive sleep apnea. A narrative review.

2018

Prevalence of both chronic kidney disease (CKD) and obstructive sleep apnea (OSA) is continuously increasing. Moreover, the prevalence of OSA increases as kidney function declines and is higher among patients with end-stage renal disease (ESRD). In addition, OSA is recognized as a potential nontraditional risk factor for development and progression of CKD. Continuous positive airway pressure (CPAP) plays a pivotal role in the management of OSA, eliminating patients' symptoms and improving their quality of life. Recent studies suggested that CPAP treatment may have beneficial effects on kidney function among patients with OSA. This narrative review summarizes the existing knowledge on the as…

Tubular cell damage may be the earliest sign of renal extrahepatic manifestation caused by Hepatitis C

2021

Publisher Copyright: © 2021 Kaartinen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Chronic kidney disease (CKD) is one of the most well-known extrahepatic manifestations caused by hepatitis C infection (HCV). CKD is typically discovered at a late stage. HCVnephropathy may show different histopathologic patterns, as both glomerular and tubulointerstitial damage have been described. Identification of patients with early renal manifestations would be beneficial to provide treatment and avoid progres…

Arterial Hypertension and the Hidden Disease of the Eye: Diagnostic Tools and Therapeutic Strategies.

2022

Hypertension is a major cardiovascular risk factor that is responsible for a heavy burden of morbidity and mortality worldwide. A critical aspect of cardiovascular risk estimation in hypertensive patients depends on the assessment of hypertension-mediated organ damage (HMOD), namely the generalized structural and functional changes in major organs induced by persistently elevated blood pressure values. The vasculature of the eye shares several common structural, functional, and embryological features with that of the heart, brain, and kidney. Since retinal microcirculation offers the unique advantage of being directly accessible to non-invasive and relatively simple investigation tools, the…

ENDOSCOPIC FINDINGS IN CHRONIC RENAL FAILURE: REVIEW OF LITERATURE

2012

Chronic kidney Disease (CKD) is associated with several gastrointestinal diseases, documented with endoscopy. we revisited internation experience about endoscopic pictures in these patients, analyzing only the pre-transplantation period. Gastritis, esophagitis, duodenitis, gastrointestinal bleeding, intestinal ischaemia, angiodysplasia and diverticula are the most common findings, but others are reported too. Every author has different data and percentages, and further studies are necessary to assess the relation between CKD and gastrointestinal diseases. CKD is often part of a multisystem damage, that makes the management of the patinet critical. The aim of this review is to consider patie…