Search results for "Chronic"
showing 10 items of 3309 documents
Acute and chronic pain
2017
Acute or chronic pain is a complex multidimensional neuronal response that draws attention to damaging or potentially damaging situations. A complex cascade of events takes place between the triggering occurrence of irritation and the final result of pain perception. In the beginning the nociceptor transforms the noxious threat into a signal.
Progressive right ventricular dysfunction and exercise impairment in patients with heart failure and diabetes mellitus: insights from the T.O.S.CA. R…
2022
Abstract Background Findings from the T.O.S.CA. Registry recently reported that patients with concomitant chronic heart failure (CHF) and impairment of insulin axis (either insulin resistance—IR or diabetes mellitus—T2D) display increased morbidity and mortality. However, little information is available on the relative impact of IR and T2D on cardiac structure and function, cardiopulmonary performance, and their longitudinal changes in CHF. Methods Patients enrolled in the T.O.S.CA. Registry performed echocardiography and cardiopulmonary exercise test at baseline and at a patient-average follow-up of 36 months. Patients were divided into three groups based on the degree of insulin impairmen…
Comparison of Disease Clusters in Two Elderly Populations Hospitalized in 2008 and 2010
2013
<b><i>Background:</i></b> As chronicity represents one of the major challenges in the healthcare of aging populations, the understanding of how chronic diseases distribute and co-occur in this part of the population is needed. <b><i>Objectives:</i></b> The aims of this study were to evaluate and compare patterns of diseases identified with cluster analysis in two samples of hospitalized elderly. <b><i>Methods:</i></b> Data were obtained from the multicenter ‘Registry Politerapie SIMI (REPOSI)' that included people aged 65 or older hospitalized in internal medicine and geriatric wards in Italy during 2008 and 2010. The s…
Pegylated interferon α plus ribavirin for the treatment of chronic hepatitis C: A multicentre independent study supported by the Italian Drug Agency
2014
a b s t r a c t Background: Data on the efficacy of Peg-interferon/ribavirin therapy for chronic hepatitis C are mostly derived from treatment of selected patients enrolled in clinical trials. This study aimed to assess the effectiveness of Peg-interferon/ribavirin therapy in “real world” chronic hepatitis C patients in Italy. Methods: Independent observational multicentre study including consecutive patients receiving Peginterferon/ribavirin in the 18 months before (retrospective phase) and after (prospective phase) the start of the study. Results: 4176 patients were eligible. The final study population consisted of 2051 patients in the retrospective and 2073 in the prospective phase. Sust…
Latent tubercolosis infection in patients with cronic plaque psoriasis: evidence from the Italian Psocare Registry
2015
SummaryBackground The nationwide prevalence of latent tuberculosis infection (LTBI) in Italian patients with psoriasis has never been investigated. Objectives To estimate the nationwide prevalence of LTBI in Italian patients with psoriasis who are candidates for systemic treatment. Methods Data were obtained from the Psocare Registry on those patients (n = 4946) with age > 18 years, systemic treatment at entry specified and tuberculin skin test (TST) performed according to the Mantoux method. LTBI diagnosis was based on a positive TST result in the absence of any clinical, radiological or microbiological evidence of active tuberculosis. Results Latent tuberculosis infection was diagnosed in…
Cutting Edge: Trans-Signaling via the Soluble IL-6R Abrogates the Induction of FoxP3 in Naive CD4+CD25− T Cells
2007
Abstract Chronic inflammatory diseases may develop when regulatory T cells (Tregs) fail to control the balance between tolerance and immunity. Alternatively, activated immune cells might prevent the induction or activation of Tregs in such diseases. In this study, we demonstrate that trans-signaling into T cells via the soluble IL-6 receptor completely abrogates the de novo induction of adaptive Tregs. Mechanistically, IL-6 trans-signaling augmented the expression of the TGF-β signaling inhibitor SMAD7. Consequently, SMAD7 overexpression in T cells using newly created transgenic mice rendered CD4+CD25− T cells resistant to the induction of FoxP3. Finally, IL-6 trans-signaling inhibited Treg…
Le théâtre des vanités mondaines : le Bois de Boulogne dans les chroniques zoliennes
2018
francaisL’œuvre journalistique d’Emile Zola touche tous les aspects de la realite parisienne de son epoque : des sujets « serieux », sociaux et politiques, a ceux qu’on peut qualifier de legers, voire frivoles. L’existence de la gentry de la capitale sous le regne de Napoleon III compte, selon l’ecrivain, selon ces derniers, etant focalisee sur les apparences et sur un affichage ostentatoire de la richesse. En effet, la vanite s’avere etre le defaut principal de la belle societe parisienne du Second Empire, et le paraitre devient sa nouvelle religion. La scene preferee de la parade quotidienne des mondains est le Bois de Boulogne, recemment transforme en un parc a l’anglaise. L’article se p…
How To Combine Ozone Therapies With Other Modalities For Maximum Efficacy
2018
In order to use Bio-Oxidative Therapies effectively, a small shift in thinking is needed. One needs to shift from Disease Literacy to Healing Literacy This shift in thinking leads to the inevitable conclusion that: Impaired Oxygen Signaling is the common denominator for all disease. Impaired Oxygen Signaling affects: • O2 driven energetics • O2's detergent function • O2's cellular repair function • O2's renewal function It is important to be aware of Oxygen's multiple functions in order to appreciate the importance of the role bio-oxidative therapies play in the reversal of disease conditions. In fact, no treatment…
Imperative and Elective Indications for Nephron-Sparing Surgery for Renal Tumors: Long-Term Oncological Follow-Up
2010
INTRODUCTION: Nephron-sparing surgery (NSS) is mandatory for patients with renal tumors in both kidneys or in a solitary kidney in order to preserve renal function (imperative indication). NSS has also become the gold standard (elective indication) for small unilateral renal tumors (< 4 cm) with a normal contralateral kidney. We report the oncological long-term follow-up of NSS of our own series and discuss the results of the current literature. PATIENTS AND METHODS: From 1979 until 2006, a total of 851 patients was treated at our institu-tion by NSS. The mean tumor diameter was 3 cm (0.5-11 cm) for elective cases and 4.2 cm (1.2-11 cm) for imperative cases. The median follow-up for electiv…
Procedural characteristics and outcomes following chronic total occlusion coronary intervention: pooled analysis from 5 registries.
2021
Background Recent improvement in clinical skills, technology and hardware has resulted in improved success rates with chronic total occlusion (CTO) percutaneous coronary intervention (PCI). We performed a study level pooled analysis from the five largest registries of percutaneous coronary intervention (PCI) of CTO. Research design and methods We conducted pooled analysis of 9500 patients in registries and data on procedural characteristics, technical success, and MACCE was collected. Results A total of 9500 patients were included in the analysis. Mean age was 65.4 years with previous CABG in 24.8%, reattempt procedure in 24.8% and mean JCTO score was 2.2. Final wiring strategy in hybrid al…