6533b837fe1ef96bd12a3462

RESEARCH PRODUCT

Latent tubercolosis infection in patients with cronic plaque psoriasis: evidence from the Italian Psocare Registry

P GisondiS CazzanigaS ChimentiM MaccaroneM PicardoG GirolomoniL NaldiPsocare Study Group. Griseta VA MiracapilloM AzziniL MocciM MicheliniA OffidaniL BernardiniA CampanatiG RicottiAlessandro GiacchettiM NoratF GualcoA CastelliA CucciaA DianaG RoncaroloMa BelliMa BaldassarreG SantoroGa VenaF Lo ConsoleR FiloticoV MastrandreaB BrunettiF MusumeciE CarrabbaP Dal MasF AnnicchiaricoB BenvegnùG SpazianiF CusanoS Saletta IannazzoneA GalluccioM PezzaL MarchesiG ImbertiA ReseghettiClaudia BarberaMatteo ReggianiA LanzoniA PatriziF BardazziA AntonucciS De TommasoR BalestriW WallnoferF IngannamorteP Calzavara-pintonS IannazziC ZaneR CapezzeraS BassisiMt RossiV AltamuraW ViglCarla Schettino NobileN AsteS MurgiaC MughedduG ScuderiF BaglieriC Di DioE Cilioni GrilliC MastronardiCp AgnusdeiA AntrilliL AulisaU RaimondoG Scotto Di LuzioVc BattarraP FarroR PlaitanoG MicaliMl MusumeciMassimino D'armientoM Li CalziSebastiano Vittorio La GrecaCristiana Maria PettinatoG SapienzaG Valenti De Giacomo PfD D'amicoFederica ArcangeliD BrunelliE GhettiAugusta TulliG AssiP AmerioG LariaF PrestinariS SpadaforaM CoppolaG CaresanaE PezzarossaE DomaneschiC FelisiL DonatoM BerteroL MussoS Pa LazziniP BruscinoUc AgozzinoM OttavianiCristiana SimonciniA VirgiliF OstiP FabbriWalter VolpiM CaproniT LottiF PrignanoG BuggianiM TroianoG FeniziA AltobellaA AmorusoM CondelloA GoffredoMg RighiniF AlessandriniF SatolliM ZampettiE BertaniS FossatiA ParodiM BurlandoC FiorucciA NigroG GhigliottiL MassoneGm MoiseM SerraiG CannataAm CampagnoliM DalyC LeporatiR PeilaGiovanna FilosaL BugattiM NicoliniG NazzariR CestariFabio AnastasioFm LarussaN PolliceF De FrancescoG MazzocchettiK PerisMc FargnoliA Di CesareL De AngelisG FlatiAs BiamonteGiovanni QuartaM CongedoA CarcaterraD StrippoliD FideliFilippo MarsiliM CelliM CeccariniL BachiniMaria Federica D OriaV SchirripaC De FilippiP MartiniE LapucciC MazzatentaA GhilardiM SimonacciA BettacchiR GascoA ZancaSimone BattistiniS DattolaR VernaciF PostorinoPf ZampieriMaria Cristina Padovan González Intchaurraga MaJ LadurnerB GuarneriSerena Cannavo'C ManfrèF BorgiaA Puglisi GuerraP SedonaA CattaneoC CarreraC FracchiollaN MozzanicaL PrezzemoloS MenniA LodiP MartinoM MontiL ManciniF SacriniGf AltomareM TaglioniC LovatiSr MercuriG SchiesariA GiannettiA ContiC LasagniM GrecoG RonsiniS SchianchiC FiorentiniS NigliettaR MigliettaC PadalinoD CrippaM PiniE RossiD TosiM ArmasV RuoccoF AyalaN BalatoF GaudielloGf CimminoG MonfrecolaL GalloG ArgenzianoE FulgioneG BerrutiR MozzilloS CeparanoI De MicheleD GiorgianoG LeighebS DeleddaA PesericoM AlaibacS PiasericoL SchiesariG DanI MatteiE OroM AricòMr BongiornoRosalia AngileriS AmatoF TodaroM MiliotoR BellastroS Di NuzzoG De PanfilisM ZanniG BorroniR CananziV BrazzelliP LisiL StingeniK HanselV PierfeliceS DonelliD RastelliM GasperiniP BarachiniR CecchiL BartoliMaria Gabriella PavesiS De PaolaMt CorradinF RicciutiAlessandro PiccirilloL ViolaM TataranniMg MautoneG Lo ScoccoMc Niccoli Brunasso Vernetti AmG GaddoniFabio Di RestaMc CasadioMc ArcidiacoMc LuvaràGuglielmo Albertini PetroniValerio Di LerniaE GuareschiS CatraniM MorriP AmerioC De SimoneM D'agostinoI AgostinoS CalvieriF CantoresiA RichettaPaola SorgiC CarnevaleF NicolucciE BerardescaM ArdigòC De FeliceE GubinelliS ChimentiMarina TalamontiG CamploneGiulio CrucianiF RiccardiR BarbatiG ZumianiW PaganiPg MalagoliR PellicanoDiego DonadioC Di VitoF CottoniMa MontesuC PiroddaG AddisP MarongiuA FarrisAnna Maria CacciapuotiA VerriniG DesirelloM GnoneM FimianiM PellegrinoG CastelliL ZappalàG SesanaV IngordoE VozzaD Di GiuseppeD FascioccoP NespoliM PapiniM CicolettiMg BernengoM OrtoncelliA BonvicinoG CapellaGc DoveilM ForteA PeroniB SalomoneP SavoiaM PippioneLudovica ZichichiM FrazzittaG De LucaG ZumianiL TasinD SimonettoS RosG TrevisanM PatamiaS MiertusovaPietro PatroneA FrattasioFabiola PiccirilloS La SpinaL Di GaetanoV MarzocchiA MotoleseCaterina VenturiP SedonaFrancesco GaiS PasquinucciRm BellazziTommaso SilvestriG GirolomoniP GisondiC Veller FornasaGp. Trevisan

subject

RegistrieMaletaiwanAntitubercular AgentsBiological Factorquantiferon-tb-goldAntitubercular AgentBiological FactorsexperienceResidence Characteristics80 and overPrevalenceRegistriesYoung adultriskAged 80 and overLatent TuberculosiLatent tuberculosispsoriasisMiddle AgedItalyFemaletubercolosistubercolosiAdolescent; Adult; Age Distribution; Aged; Aged 80 and over; Antitubercular Agents; Biological Factors; Chronic Disease; Female; Humans; Italy; Latent Tuberculosis; Male; Middle Aged; PUVA Therapy; Prevalence; Psoriasis; Registries; Residence Characteristics; Sex Distribution; Tuberculin Test; Young Adult; 2708Humanmedicine.drugAdultmedicine.medical_specialtyAdolescentchronic plaque psoriasisTuberculinconsensus statementtubercolosis; psoriasisDermatology.Young Adulttuberculosis infectionSettore MED/35Age DistributionLatent TuberculosisInternal medicinePsoriasismedicineAdalimumabfactor antagonistsHumansPsoriasisnecrosis-factor blockers; quantiferon-tb-gold; consensus statement; factor antagonists; systemic treatment; therapy; experience;taiwan; assay; risknecrosis-factor blockersSex DistributionAdolescent; Adult; Age Distribution; Aged; Aged 80 and over; Antitubercular Agents; Biological Factors; Chronic Disease; Female; Humans; Italy; Latent Tuberculosis; Male; Middle Aged; PUVA Therapy; Prevalence; Psoriasis; Registries; Residence Characteristics; Sex Distribution; Tuberculin Test; Young AdultPUVA TherapyAgedPsoriasiHistory of tuberculosistherapytuberculosis infection chronic plaque psoriasisItalian Psocare Registrybusiness.industryTuberculin TestOdds ratiosystemic treatmentassaymedicine.diseasebacterial infections and mycosesConfidence intervalSurgeryResidence CharacteristicChronic DiseaseItalian Psocare Registrybusiness2708

description

SummaryBackground The nationwide prevalence of latent tuberculosis infection (LTBI) in Italian patients with psoriasis has never been investigated. Objectives To estimate the nationwide prevalence of LTBI in Italian patients with psoriasis who are candidates for systemic treatment. Methods Data were obtained from the Psocare Registry on those patients (n = 4946) with age > 18 years, systemic treatment at entry specified and tuberculin skin test (TST) performed according to the Mantoux method. LTBI diagnosis was based on a positive TST result in the absence of any clinical, radiological or microbiological evidence of active tuberculosis. Results Latent tuberculosis infection was diagnosed in 8·3% of patients with psoriasis (409 of 4946). The prevalence of LTBI was lower in patients on biologics than in those on conventional systemic treatments, ranging from 4·3% (19 of 444) of patients on adalimumab to 31% (eight of 26) of those on psoralen–ultraviolet A (P < 0·05). Independent factors associated with LTBI were male sex [odds ratio (OR) 1·30, 95% confidence interval (CI) 1·04–1·62; P = 0·02], age over 55 years (OR 2·93, 95% CI 2·18–3·93; P < 0·001) and being entered into a conventional treatment (OR 3·83, 95% CI 3·10–4·74; P < 0·001). Positive history of tuberculosis was seen in 1% of patients (n = 49). Conclusions The nationwide prevalence of LTBI in Italian patients with psoriasis candidate to systemic treatment is high, and screening is recommended prior to biological treatment.

yearjournalcountryeditionlanguage
2015-01-01
10.1111/bjd.13539http://hdl.handle.net/11573/1096379