Search results for "Circulation"
showing 10 items of 1137 documents
Algorithms for the inference of causality in dynamic processes: Application to cardiovascular and cerebrovascular variability
2015
This study faces the problem of causal inference in multivariate dynamic processes, with specific regard to the detection of instantaneous and time-lagged directed interactions. We point out the limitations of the traditional Granger causality analysis, showing that it leads to false detection of causality when instantaneous and time-lagged effects coexist in the process structure. Then, we propose an improved algorithm for causal inference that combines the Granger framework with the approach proposed by Pearl for the study of causality among multiple random variables. This new approach is compared with the traditional one in theoretical and simulated examples of interacting processes, sho…
Microvascular angina in diabetic patients with uninjured coronary arteries
2012
Received 14 March 2012; Accepted 26 July 2012 Abstract: Aims: The study aims at the evaluation, of patients with chest pain and uninjured coronary arteries, and the impact of diabetes mellitus on coronary microcirculation. Moreover we want to verify whether a correlation between myocardial scintigraphy results and coronary angiography or not. Methods: The study population included 316 patients (173 males,143 females) with uninjured coronary arteries. Patients with chest pain (208) were divided into two populations: diabetics (72) and non-diabetics (136).We compared 66 patients with a myocardial scintigraphy with results of angiographic indexes. On angiographic images we evaluated, on the th…
Oxidative stress upregulates the NMDA receptor on cerebrovascular endothelium.
2009
N-methyl-d-aspartate receptor (NMDA-R)-mediated oxidative stress has been implicated in blood-brain barrier (BBB) disruption in a variety of neuropathological diseases. Although some interactions between both phenomena have been elucidated, possible influences of reactive oxygen species (ROS) on the NMDA-R itself have so far been neglected. The objective of this study was to examine how the cerebroendothelial NMDA-R is affected by exposure to oxidative stress and to assess possible influences on BBB integrity. RT-PCR confirmed several NMDA-R subunits (NR1, NR2B-D) expressed in the bEnd3 cell line (murine cerebrovascular endothelial cells). NR1 protein expression after exposure to ROS was ob…
Zebrafish Embryos Allow Prediction of Nanoparticle Circulation Times in Mice and Facilitate Quantification of Nanoparticle–Cell Interactions
2020
The zebrafish embryo is a vertebrate well suited for visualizing nanoparticles at high resolution in live animals. Its optical transparency and genetic versatility allow noninvasive, real-time observations of vascular flow of nanoparticles and their interactions with cells throughout the body. As a consequence, this system enables the acquisition of quantitative data that are difficult to obtain in rodents. Until now, a few studies using the zebrafish model have only described semiquantitative results on key nanoparticle parameters. Here, a MACRO dedicated to automated quantitative methods is described for analyzing important parameters of nanoparticle behavior, such as circulation time and…
Excited states engineering enables efficient near-infrared lasing in nanographenes
2021
The spectral overlap between stimulated emission (SE) and absorption from dark states (i.e. charges and triplets) especially in the near-infrared (NIR), represents one of the most effective gain loss channel in organic semiconductors. Recently, bottom-up synthesis of atomically precise graphene nanostructures, or nanographenes (NGs), has opened a new route for the development of environmentally and chemically stable materials with optical gain properties. However, also in this case, the interplay between gain and absorption losses has hindered the attainment of efficient lasing action in the NIR. Here, we demonstrate that the introduction of two fluoranthene imide groups to the NG core lead…
Carbon-doped titania as a precursor for titanate nanotubes
2018
Carbon-doped titania was fabricated via carbothermal treatment in nitrogen–acetylene gas flow and further used as a precursor for multiwalled titanate nanotube (TNT) synthesis via alkaline hydrothermal route. Investigation of the reaction products after hydrothermal treatment of carbon-doped titania using Transmission electron microscopy, X-ray diffraction, and Brunauer–Emmett–Teller method shows the successful formation of TNTs. The presence of carbon was proved although the type of incorporation could not be certified. All samples show approximately the same carbon content before and after hydrothermal treatment. An increasing pretreatment temperature of titania precursor powders yields m…
Sensitivity Analysis of the MASLWR Helical Coil Steam Generator Using TRACE
2011
Accurate simulation of transient system behavior of a nuclear power plant is the goal of systems code calculations, and the evaluation of a code's calculation accuracy is accomplished by assessment and validation against appropriate system data. These system data may be developed either from a running system prototype or from a scaled model test facility, and characterize the thermal hydraulic phenomena during both steady state and transient conditions. The identification and characterization of the relevant thermal hydraulic phenomena, and the assessment and validation of thermal hydraulic systems codes, has been the objective of multiple international research programs. The validation and…
Luminescence Properties of ZnO Nanocrystals and Ceramics
2008
The luminescence excitation spectra, luminescence spectra and the nanosecond-scale decay kinetics were studied. The ZnO and ZnO:Al nanopowders were prepared by vaporization-condensation in a solar furnace using different raw powders: commercial, hydrothermal and those obtained by plasma synthesis. Exciton-phonon as well as exciton-exciton interaction processes in nanopowders, a bulk crystal and ZnO ceramics were studied and compared. The fast decay and low afterglow intensity of ZnO nanopowders and ceramics support these materials for scintillators.
Magnetic resonance imaging of dissolved hyperpolarized 129Xe using a membrane-based continuous flow system.
2009
Abstract A technique for continuous production of solutions containing hyperpolarized 129Xe is explored for MRI applications. The method is based on hollow fiber membranes which inhibit the formation of foams and bubbles. A systematic analysis of various carrier agents for hyperpolarized 129Xe has been carried out, which are applicable as contrast agents for in vivo MRI. The image quality of different hyperpolarized Xe solutions is compared and MRI results obtained in a clinical as well as in a nonclinical MRI setting are provided. Moreover, we demonstrate the application of 129Xe contrast agents produced with our dissolution method for lung MRI by imaging hyperpolarized 129Xe that has been…
Evolution de la circulation oécanique profonde durant le Crétacé : apport des isotopes du néodyme
2014
The Cretaceous is depicted as the warmest period of the last 300 Ma. The oceanic circulation and location of the source zones of deep-waters are essential to understand the role of oceans in the evolution of the climate during the Cretaceous, yet they remain unclear for this period. The neodymium (Nd) isotopes are used to track oceanic circulation and exchanges between water masses, in both past and modern oceans. The Nd isotope composition (εNd) in the ocean is related to the nature of the surrounding continental landmasses. The oceanic currents transport this isotopic signature, thus every oceanic basin acquires a singular εNd. Unequivocal interpretations of the Cretaceous seawater εNd va…