6533b7d8fe1ef96bd1269a7b

RESEARCH PRODUCT

Magnetic resonance imaging of dissolved hyperpolarized 129Xe using a membrane-based continuous flow system.

Kerstin MünnemannLaura M. SchreiberN. AmorHans Wolfgang SpiessPaul-philipp ZänkerPeter BlümlerAlexander ScholzJörg SchmiedeskampF. M. Meise

subject

Nuclear and High Energy PhysicsPulmonary Circulationmedicine.diagnostic_testContinuous flowChemistryPhantoms ImagingBiophysicsLung perfusionMagnetic resonance imagingBiocompatible MaterialsMembranes ArtificialCondensed Matter PhysicsBiochemistryMagnetic Resonance ImagingImaging phantomSolutionsMembraneNuclear magnetic resonancemedicineImage Processing Computer-AssistedRespiratory MechanicsXenon IsotopesHyperpolarization (physics)Lung

description

Abstract A technique for continuous production of solutions containing hyperpolarized 129Xe is explored for MRI applications. The method is based on hollow fiber membranes which inhibit the formation of foams and bubbles. A systematic analysis of various carrier agents for hyperpolarized 129Xe has been carried out, which are applicable as contrast agents for in vivo MRI. The image quality of different hyperpolarized Xe solutions is compared and MRI results obtained in a clinical as well as in a nonclinical MRI setting are provided. Moreover, we demonstrate the application of 129Xe contrast agents produced with our dissolution method for lung MRI by imaging hyperpolarized 129Xe that has been both dissolved in and outgassed from a carrier liquid in a lung phantom, illustrating its potential for the measurement of lung perfusion and ventilation.

yearjournalcountryeditionlanguage
2009-11-01Journal of magnetic resonance (San Diego, Calif. : 1997)
10.1016/j.jmr.2009.08.004https://pubmed.ncbi.nlm.nih.gov/19729327