Search results for "Cité"

Les études coût-efficacité appliquées à l'emploi des nouveaux moyens d'éducation

1979

International audience

Understanding the fluctuations of perceived authenticity in cultural tourism : an investigation of Bali and Alsace contexts

2022

The marketing of cultural tourism faces a dilemma between maximizing the economic return and nurturing the culture’s social functions. It needs to attract segments driven by cultural motifs, through a differentiation based on authenticity. Perceived authenticity changes over a time, but how it does remains elusive to researchers. This research investigated fluctuations of existential authenticity in cultural tourists in Bali. Participants were purposively and conveniently-sampled among visitors of cultural attractions. It comprised two stages: qualitative for building the model, and quantitative fortesting the variables. The first employed Grounded Theory interviewing 24 visitors, found the…

"Saber vender o de cómo crear una (sana) adicción. Las campañas de Turespaña en Francia: de “Touché par l’Espagne” a “L’ Espagne, j’en ai besoin""

2014

International audience

Modeling of neuron-astrocyte interaction : application to signal and image processing

2022

The introduction of the tripartite synapse and the discovery of calcium wave propagation motivated our research to explore the potential of astrocytes as active components in brain circuits. For decades, astrocytes have been considered passive cells whose primary function is metabolic and structural support to neurons; however, recent physiological measurements suggest that astrocytes modulate neural communication, strengthen synaptic efficacy, enhance synchronization, and promote homeostasis. Inspired by these biological functions, this research aimed to implement astrocytes in artificial spiking networks for deep learning applications. First, we modeled the biological interaction between …

Cancer et environnement : expertise collective

2008

Les cancers représentent en France la première cause de mortalité chez les hommes et la deuxième cause chez les femmes et figurent parmi les pathologies pouvant être liées à l’environnement. À la demande de l’Afsset, l’Inserm a réuni un groupe d’experts afin d’établir un bilan des connaissances sur les liens entre l’exposition à des facteurs physiques, chimiques ou biologiques présents dans l’atmosphère, l’eau, les sols ou l’alimentation et neuf types de cancers en augmentation au cours des vingt-cinq dernières années : les cancers du poumon, les mésothéliomes, les hémopathies malignes, les tumeurs cérébrales, les cancers du sein, de l’ovaire, du testicule, de la prostate etde la thyroïde. …

Synthesis of mesoporous silica nanoparticles (MSNs) and encapsulation of cisplatin for targeted cancer therapies

2014

The aim of this PhD thesis is to elaborate mesoporous silica nanoparticles (MSNs) able to sustain the release of cisplatin into the intracellular compartments of solid tumors. The parametric study shows that morphological, structural and textural properties of MSNs-MCM-41, synthesized by sol-gel reaction by using TEOS as a silica source and CTAB as a structure-directing agent, depend on pH, stirring speed, temperature and extraction process of CTAB. The synthesis atmosphere has to be controlled in order to avoid the presence of ethanol and carbonate species which are responsible of necks between particles generating unstable suspensions of MSNs.MSNs were functionalized in order to control t…

Valorization of natural drug products : from extraction to encapsulation

2020

This thesis was carried out at the Laboratory of Pharmacognosy and the Laboratory of Pharmaceutical technology, at the UFR Sciences de Santé, circonscription Pharmacy, in the University of Burgundy Franche-Comté, to find new natural molecules to encapsulate. First of all, we focused on the natural saponins from plants of the Vietnam biodiversity and the french horticulture, belonging to the three genera Dracaena, Cordyline (Asparagaceae) and Weigela (Caprifoliaceae). The work led to the successful isolation and elucidation of 42 natural saponins using various chromatographic techniques. The structures were determined by ESI mass spectrometry and NMR spectroscopy. Among the 17 pure compounds…

INSTABILITY OF HAMILTONIAN SYSTEMS IN THE SENSE OF CHIRIKOV AND BIFURCATION IN A NON LINEAR EVOLUTION PROBLEM EMANATING FROM PHYSICS

2004

We prove the existence of a minimal geometrico-dynamical condition to create hyperbolicity in section in the vicinity of a transversal homoclinic partially hyperbolic torus in a near integrable Hamiltonian system with three degrees of freedom. We deduce in this context a generalization of the Easton's theorem of symbolic dynamics. Then we give the optimal estimation of the Arnold diffusion time along a transition chain in the initially hyperbolic Hamiltonian systems with three degrees of freedom with a surrounding chain of hyperbolic periodic orbits .In a second part, we describe geometrically a mechanism of diffusion studied by Chirikov in a near integrable Hamiltonian system with three de…

Etude des Etats Vibrationnels Très Excités des Molécules Pyramidales Non Planes.

2006

Chemical and biological study of saponins isolated from three malagasy species belonging to Caryophyllaceae, Pittosporaceae and Solanaceae families

2013

This thesis was carried out in the Laboratory of Pharmacognosy, in the Pharmacy section of the University of Burgundy. The principal theme of this laboratory is the research of natural compounds from tropical biodiversity, mainly saponins. In this context, the study of Malagasy plants, Polycarpaea corymbosa Lamk. (CARYOPHYLLACEAE), Pittosporum verticillatum Bojer subsp. verticillatum (PITTOSPORACEAE), Solanum incanum L. and S. heteracanthum Dunal. (SOLANACEAE) led to the isolation of fifteen natural glycosides by column chromatography, medium pressure liquid chromatography, flash chromatography, and vacuum liquid chromatography. The structures were elucidated mainly by the use of spectrosco…