Search results for "Class"

Aikalaisanalyysi epävarmasta työstä ja äitiydestä

2020

Resolvent estimates for elliptic quadratic differential operators

2011

Sharp resolvent bounds for non-selfadjoint semiclassical elliptic quadratic differential operators are established, in the interior of the range of the associated quadratic symbol.

Vortex dynamics in rotating counterflow and plane Couette and Poiseuille turbulence in superfluid Helium

2008

An equation previously proposed to describe the evolution of vortex line density in rotating counterflow turbulent tangles in superfluid helium is generalized to incorporate nonvanishing barycentric velocity and velocity gradients. Our generalization is compared with an analogous approach proposed by Lipniacki, and with experimental results by Swanson et al. in rotating counterflow, and it is used to evaluate the vortex density in plane Couette and Poiseuille flows of superfluid helium.

Aplidin® induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 ph…

2006

Aplidin® is an antitumor agent in phase II clinical trials that induces apoptosis through the sustained activation of Jun N-terminal kinase (JNK). We report that Aplidin® alters glutathione homeostasis increasing the ratio of oxidized to reduced forms (GSSG/GSH). Aplidin® generates reactive oxygen species and disrupts the mitochondrial membrane potential. Exogenous GSH inhibits these effects and also JNK activation and cell death. We found two mechanisms by which Aplidin® activates JNK: rapid activation of Rac1 small GTPase and downregulation of MKP-1 phosphatase. Rac1 activation was diminished by GSH and enhanced by L-buthionine (SR)-sulfoximine, which inhibits GSH synthesis. Downregulatio…

Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis.

2005

Objective— Sedentary lifestyle is associated with increased cardiovascular events. The underlying molecular mechanisms are incompletely understood. Reactive oxygen species (ROS) contribute to endothelial dysfunction and atherosclerosis. An important source of vascular ROS is the NADPH oxidase. Methods and Results— C57BL6 mice were subjected to regular housing (physical inactivity) or voluntary training on running wheels (6 weeks). Inactivity increased vascular lipid peroxidation to 148±9% and upregulated superoxide release to 176±17% (L-012 chemiluminescence) and 188±29% (cytochrome C reduction assay), respectively. ROS production was predominantly increased in the endothelium and the medi…

”Rakennettu amerikkalaisuus” : semioottinen analyysi Classic American Dinerin ravintolainteriööristä

2015

Tutkielmassani analysoin Jyväskylässä sijaitsevan Amerikka-teemaisen Classic American Diner-ketjuravintolan interiöörin merkkikieltä esimerkkikuvien kautta. Puran interiööriä semioottisesta näkökulmasta Roland Barthesin esittämien kuvan retoriikan analyysin vaiheiden avulla, nostaen kuvista esille ideologioita.

Kirkonrakentajasuku Rijf. Pohjalaisen kirkonrakentajasuvun rakennus- ja suunnittelutuotanto sekä toiminta kustavilaisen aikakauden Suomessa

2016

This dissertation deals with the building and design work of the church builder family Rijf in Österbotten during the Gustavian Period. The Rijfs were Finland- Swedes and entailed four mason-based master builders: Thomas Rijf (1726-1803), his sons Jacob (1753-1808) and Carl (1756-1801), and Jacob´s son Carl Jacobsson Rijf (1783-1808). The most famous member of the family was Jacob Rijf. He was the first Finnish master builder to study at the Royal Swedish Academy of Arts and was supervised by the leading architects of the Board of Public Works and Buildings, Carl Fredrik Adelcrantz (1716-1796) and Olof Tempelman (1745-1816). In 1794 Jacob Rijf was appointed as the provincial master builder …

Application of selected supervised classification methods to bank marketing campaign

2016

Supervised classification covers a number of data mining methods based on training data. These methods have been successfully applied to solve multi-criteria complex classification problems in many domains, including economical issues. In this paper we discuss features of some supervised classification methods based on decision trees and apply them to the direct marketing campaigns data of a Portuguese banking institution. We discuss and compare the following classification methods: decision trees, bagging, boosting, and random forests. A classification problem in our approach is defined in a scenario where a bank’s clients make decisions about the activation of their deposits. The obtained…

Il valore dell’alta statura: spunti di riflessione sulla proceritas nelle rappresentazioni storiche romane

2018

Il contributo è dedicato all’impiego iconografico della proceritas, l’alta statura, nell’arte ufficiale romana. Per indicarne l’importanza, già nella pittura funeraria etrusca è noto l’uso di raffigurare personaggi diversamente dimensionati. Nell’arte romana tale fenomeno è ben conosciuto nelle produzioni private mentre è più raro sui monumenti pubblici. In questo tipo di opere e in analogia al suo significato in Etruria, la proceritas ha la funzione di mettere in risalto una particolare figura. Così nel rilievo che decora l’Ara Pacis Augusto è leggermente più alto delle persone che lo circondano. Allo stesso modo sul cosiddetto Altare del Belvedere conservato ai Musei Vaticani il princeps …

Enterobacter cloacae administration induces hepatic damage and subcutaneous fat accumulation in high-fat diet fed mice.

2018

Accumulating evidence indicates that gut microbiota plays a significant role in obesity, insulin resistance and associated liver disorders. Family Enterobacteriaceae and especially Enterobacter cloacae strain B29 have been previously linked to obesity and hepatic damage. The underlying mechanisms, however, remain unclear. Therefore, we comprehensively examined the effects of E. cloacae subsp. cloacae (ATCC® 13047™) administration on host metabolism of mice fed with high-fat diet (HFD). C57BL/6N mice were randomly divided into HFD control, chow control, and E. cloacae treatment groups. The E. cloacae treatment group received live bacterial cells in PBS intragastrically twice a week, every ot…