Search results for "Clero"
showing 10 items of 2052 documents
Celecoxib for recurrent sclerouveitis after syphilitic panuveitis. A case report
2011
Purpose To report a case of recurrent ocular inflammation after optimal therapy of bilateral syphilitic panuveitis responding to oral celecoxib. Methods A case report was conducted. Results A 76-year-old man presented with painful blurry vision in both eyes. Ocular examination disclosed bilateral panuveitis. Serological testing confirmed blood and cerebrospinal fluid syphilitic involvement. After 2 weeks of intravenous penicillin therapy, recurrent episodic sclerouveitis was observed. Conclusion Ocular inflammation after healing of infectious uveitis is a rare ophthalmic sequela. In an immunocompetent patient, either re-infection or immune uveitis should be evoked. Non-steroidal therapeutic…
Looking for the best therapeutical stretegy after the 24th natalizumab adiministretion. The TY-STOP study
2012
Clinical and Sociodemographic Variables and the Level of Social Support in People with Multiple Sclerosis
2019
Wstęp. Stwardnienie rozsiane (SM) jest przewlekłą, postępującą neurologiczną chorobą, która może prowadzić do znacznej niepełnosprawności. Istotnym zasobem w radzeniu sobie z SM i innymi chorobami przewlekłymi jest wsparcie społeczne.Cel. Celem badań było określenie związku pomiędzy zmiennymi klinicznymi i socjodemograficznymi a wsparciem społecznym u osób z SM.Materiał i metody. W badaniu wykorzystano Rozszerzoną Skalę Niewydolności Ruchowej (EDSS), Skalę Niepełnosprawności Neurologicznej Szpitala Guy (GNDS) oraz Berlińskie Skale Wsparcia Społecznego Grupę badaną stanowiło 137 osób ze zdiagnozowanym SM.Wyniki. Spostrzegane wsparcie społeczne nie jest powiązane ze zmiennymi klinicznymi, tak…
Nutritional evaluation and physical activity in scleroderma patients
2010
Study of the mechanisms of oxidative stress, mitochondrial function and endoplasmic reticulum stress in obesity. Role in subclinical atherosclerosis …
2019
El aumento alarmante de la prevalencia de obesidad a nivel mundial y la enorme carga de enfermedad asociada ha generado una creciente demanda de estrategias para frenar la epidemia y / o mitigar los efectos dañinos de la obesidad sobre la salud. Para ello se requiere un compromiso firme y sinérgico por parte de todas las fuerzas sociales, no sólo para desarrollar estrategias preventivas, sino también para contribuir al conocimiento de los eventos patológicos y los mecanismos involucrados en el desarrollo de esta enfermedad. Por ello, el objetivo principal de la presente tesis doctoral es profundizar en los mecanismos subyacentes de la obesidad, especialmente en aquellos relacionados con el …
Intermittent Fasting and the Possible Benefits in Obesity, Diabetes, and Multiple Sclerosis: A Systematic Review of Randomized Clinical Trials
2021
Intermittent fasting has become popular in recent years and is controversially presented as a possible therapeutic adjunct. A bibliographic review of the literature on intermittent fasting and obesity, diabetes, and multiple sclerosis was carried out. The scientific quality of the methodology and the results obtained were evaluated in pairs. Intermittent fasting has beneficial effects on the lipid profile, and it is associated with weight loss and a modification of the distribution of abdominal fat in people with obesity and type 2 diabetes as well as an improvement in the control of glycemic levels. In patients with multiple sclerosis, the data available are too scarce to draw any firm con…
Activation of the p38MAPK cascade is associated with upregulation of TNF alpha receptors in the spinal motor neurons of mouse models of familial ALS.
2005
Phosphorylated p38 mitogen-activated protein kinase (p38MAPK), but not activated c-jun-N-terminal kinase (JNK), increases in the motor neurons of transgenic mice overexpressing ALS-linked SOD1 mutants at different stages of the disease. This effect is associated with a selective increase of phosphorylated MKK3-6, MKK4 and ASK1 and a concomitant upregulation of the TNFalpha receptors (TNFR1 and TNFR2), but not IL1beta and Fas receptors. Activation of both p38 MAPK and JNK occurs in the activated microglial cells of SOD1 mutant mice at the advanced stage of the disease; however, this effect is not accompanied by the concomitant activation of the upstream kinases ASK1 and MKK3,4,6, while both …
Methylprednisolone-induced hepatotoxicity in a 16-year-old girl with multiple sclerosis.
2018
Multiple sclerosis (MS) is a chronic inflammatory disease with demyelination of the central nervous system. High-dosage corticosteroids are the first-line therapy in the acute relapsing of MS. We report a case of severe high-dose methylprednisolone-induced acute hepatitis in a patient with a new diagnosis of MS. A 16-year-old girl was admitted for urticaria, angioedema, nausea and vomiting a month later she had been diagnosed with MS and treated with high-dosage methylprednisolone. Laboratory investigations showed hepatic insufficiency with grossly elevated liver enzymes. A liver biopsy showed focal centrilobular hepatocyte necrosis with interface hepatitis. Methylprednisolone-induced hepat…
Genetic analysis of familial Alzheimer’s disease, primary lateral sclerosis and paroxysmal kinesigenic dyskinesia: a tool to uncover common mechanist…
2021
Tesis doctoral 270 p. figuras y tablas
Evaluación de los signos precoces de aterosclerosis en niños con Diabetes Mellitus tipo 1
2015
INTRODUCCIÓN La Diabetes Mellitus tipo 1 (DM1) representa un importante factor de riesgo de enfermedad cardiovascular. La ecografía de la arteria carótida común derecha se ha establecido como una técnica útil y fiable para valorar la presencia de cambios ateroscleróticos subclínicos. Estos signos precoces se manifiestan con el aumento del índice grosor íntima-media carotídeo (GIMc). Previamente a esta alteración estructural, se afecta la función endotelial, que se valora mediante la estimación de los parámetros de rigidez arterial. OBJETIVOS Evaluar el GIMc y los índices de rigidez arterial, en una población de niños con DM1, en comparación con una población de niños sanos, de similares eda…