Search results for "Clos"

Anti-GD3 antibodies are potent activators of human gamma/delta and alpha/beta positive T cells.

1995

The ganglioside GD3 has a variety of biological functions. These include stimulatory effects on proliferation, natural killer activity and cytokine production by freshly isolated peripheral T cells. In this study we have characterized anti-GD3 antibody (MoAb Z21) mediated effects on T cell clones. Our data indicate that alpha/beta TCR CD4+ and CD8+ as well as gamma/delta TCR positive T cells can be stimulated resulting in proliferation and cytokine production. This effect could be blocked by cyclosporin A and did not involve the LFA-3 or CD4 molecule. Apart from IFN-gamma and IL-2 production by T helper 1 and T helper 0 cells we have observed production of IL-4 and IL-10 by T helper 2 cells…

Legislative basis for corporate social responsibility reporting

2014

An Analysis of the Presence and Composition of OutLists at United States, Canadian, and European Medical Institutions

2019

Sexual and gender minority (SGM) medical students and physicians are exposed to bias in professional contexts. One strategy for promoting SGM visibility and inclusion within medicine is the development of institutional OutLists, which are online, opt-in lists of SGM-identified individuals affiliated with an academic institution. We present the first quantitative evaluation of publicly accessible OutLists at medical institutions in the United States, Canada, and Europe. Nineteen OutLists were identified in the United States; no OutLists were identified in other countries. All OutLists in the United States were identified at allopathic institutions with no institutional religious affiliation.…

Comparative activity of idarubicin and idarubicinol in combination with cyclosporin A in multidrug-resistant leukemia cells

1996

4-Demethoxydaunorubicin (idarubicin, IDA) is an anthracycline that has shown good cytotoxic activity in vitro against tumor cell lines displaying the multidrug-resistant (MDR) phenotype. IDA is converted in the liver into idarubicinol (2HIDA) and, in this form, seems to exert its antitumoral activity in vivo. Recent studies have shown that 2HIDA has tumoricidal activity similar to that of the parent drug when tested in vitro in sensitive neoplastic cells. In this work we compared in vitro the effects of IDA and 2HIDA used alone and in combination with 2 microM cyclosporin A (CyA) in the MDR leukemic cell lines FLCR and K562R and in their sensitive parent cell lines FLC and K562. IDA and 2HI…

Malignant tumor-like gastric lesion by Candida albicans.

2011

Boundary value steady solutions of a class of hydrodynamic models for vehicular traffic flow

2003

This paper deals with the solution of a boundary value problem related to a steady nonuniform description of a class of traffic flow models. The models are obtained by the closure of the mass conservation equation with a phenomenological relation linking the local mass velocity to the local density. The analysis is addressed to define the proper framework toward the identification of the parameter characterizing the model. The last part of the paper develops a critical analysis also addressed to the design of new traffic flow models.

Autocatalytic cleavage of Clostridium difficile toxin B.

2007

Clostridium difficile, the causative agent of nosocomial antibiotic-associated diarrhoea and pseudomembranous colitis, possesses two main virulence factors: the large clostridial cytotoxins A and B. It has been proposed that toxin B is cleaved by a cytosolic factor of the eukaryotic target cell during its cellular uptake. Here we report that cleavage of not only toxin B, but also all other large clostridial cytotoxins, is an autocatalytic process dependent on host cytosolic inositolphosphate cofactors. A covalent inhibitor of aspartate proteases, 1,2-epoxy-3-(p-nitrophenoxy)propane, completely blocked toxin B function on cultured cells and was used to identify its catalytically active prote…

Differentiation of herpes simplex virus-induced fusion from without and fusion from within by cyclosporin A and compound 48/80.

1991

Treating strains of herpes simplex virus (HSV) in culture with either cyclosporin A or compound 48/80, allowed the strains to be divided into two groups. Group 1 contains the strains ANG and HFEM of HSV-1 and Lux syn (HSV-2) producing fusion from within (FFWI) and fusion from without (FFWO). Cyclosporin A fails to inhibit both types of fusion at concentrations up to 100 microM. Strains ANG and HFEM belong to the syn 3 marker locus group identified for HSV-1. Group 2 contains all other fusion-producing strains of HSV tested so far. Cyclosporin A inhibits FFWI at concentrations as low as 10 to 20 microM. These strains belong to the syn locus marker groups 1, 2, 4 and 5. From the fact that mut…

Volatile components from aerial parts of centaurea spinosociliata seenus ssp. Cristata (Bartl.) Dostál and centaurea spinosociliata seenus ssp. spino…

2010

The paper reports on the volatile components oil from aerial parts of two Asteraceae growing wild in Croatia: Centaurea spinosociliata ssp. cristata (syn. Centaurea cristata Bartl. subsp. rabenhorstiana (Sch.Bip.) Nyman) (CSC) and C. spinosociliata ssp. spinosociliata (CSS). The volatile components were obtained by hydrodistillation from selected plants and were determined by the GC-MS system on two fused-silica capillary columns of different polarity. The oil content was 0.08 % (CSC) and 0.07 % (CSS) on a dry weight basis. Altogether 73 compounds were identified accounting for 90.8 % (CSC) and 92.8 % (CSS) of the total oil, that were characterized mainly by hydrocarbons (37.9 %; 30.4 %), s…

Comparison of simultaneous saccharification and fermentation and separate hydrolysis and fermentation processes for butanol production from rice straw

2020

Abstract Rice straw (RS) is one of the lignocellulosic wastes with the highest global production. The main objective of this study was to maximise the butanol production by Clostridium beijerinckii DSM 6422 from RS pretreated by microwave-assisted hydrothermolysis. Two different fermentation strategies were compared: separate hydrolysis and fermentation (SHF, two-step process) and simultaneous saccharification and fermentation (SSF, one-step process). In parallel, the variables that significantly affected the butanol production were screened by using fractional factorial designs. Butanol concentration and productivity at 48 h were, respectively, 8% and 173% higher in SSF than in SHF. A one-…