Search results for "Clos"

Franchisors' disclosure duty: market transparency and franchisee protection

2014

The franchisee is usually the most vulnerable part of the franchise relationship, and should therefore receive greater protection from the legal framework. In this regard, the franchisor's pre-contractual disclosure duty has evolved in its legal status. Whereas its original purpose was to ensure transparency in the market, it now serves to protect the franchisee. In this paper, we compare the franchisor's obligations established by the legal framework in Spain with those set out in the Model Law drawn up by The International Institute for the Unification of Private Law.

The Association between Cardiorespiratory Fitness and Gut Microbiota Composition in Premenopausal Women

2017

Abstract The aim of this study was to investigate the association between cardiorespiratory fitness and gut microbiota composition in premenopausal women. The participants consisted of 71 premenopausal Finnish women (aged 19–49 years). Gut microbiota were analyzed using flow cytometry, 16S rRNA gene hybridization and DNA-staining. Maximum oxygen uptake (VO₂ₘₐₓ) was assessed by respiratory gas analyzer and body composition by Bioimpdance. We found that participants with low VO₂ₘₐₓ had lower Bacteroides, but higher Eubacterium rectale-Clostridium coccoides than the high VO₂ₘₐₓ group (p < 0.05 for all). VO₂ₘₐₓ was inversely associated with EreC (r = −0.309, p = 0.01) but not with other bact…

Ikuiset naamiaiset : tulkinnallisia haasteita Choderlos de Laclos'n kirjeromaanissa Les Liaisons dangereuses

2006

“Les Liaisons dangereuses de Laclos et la transposition cinématographique de Frears”

2014

Is translation an autopoietic system?

2010

Translation is analyzed from the standpoint of its systemic properties. Translation is shown to have the capacity to observe itself and its difference from the environment. Observation being a major autopoietic factor, translation may be considered as an autopoietic system. Doubts about this hypothesis arise because of the peculiarities of communicative properties of translation. Translation plays the role of the mediating party in complex translation communication events and its communicative behavior is ‘defective’ in that translation does not act upon source messages because its communicative function is passing messages on to the target party. As a system, translation may be studied aga…

Double intercultural dialogue in the Hispanic press in the United States: the case of New York newspapers

2015

Taking as a starting point research carried out in 2000 into the concept of Hispanic identity in Spanish-language newspapers in the city of New York, this article provides a diachronic analysis of these media over the period 2000–2012. In the first study, it was established that Spanish-language newspapers reflected an intercultural dialogue among different Latino groups, thus creating a pan-Hispanic identity. In this article we wish to go a step further and explore whether the Spanish-language newspapers may also reflect, and foster, a second level of intercultural dialogue between the Hispanic and the non-Hispanic communities. In order to carry out this research, a qualitative content ana…

Developing creativity through ICT and Music Teachers’ Training: a biographical experience

2021

O texto faz parte de uma investigação qualitativa biográfico-narrativa que temos em curso, e que se processa mediante a obtenção de testemunhos de professores e investigadores que formam professores com o auxílio das TIC de modo a promover as competências de criatividade, colaboração, cooperação e comunicação, entendidas como essenciais para o desenvolvimento de uma educação integral, promotora da sustentabilidade curricular e da cidadania participativa. Neste artigo, damos conta da experiência de uma professora e investigadora, Cristina Arriaga Sanz, que se dedica à formação de professores no âmbito da Educação Musical no ensino superior espanhol, de que salientaremos a relação estreita co…

Contexto editorial, cultural y socio-político de la edición príncipe de la «Historia de la doncella Teodor» (Toledo: Pedro Hagenbach, 1500-1501)

2021

The material analysis of the only surviving copy of the editio princeps of the Historia de la doncella Teodor allows us to date it back to the incunabula era and to attribute its printing to Pedro Hagenbach’s workshop. The close relationship amongst Hagenbach’s workshop, the reformist project of Archbishop Cisneros, and the interests of the Catholic Monarchs sets an editorial and cultural context that supports the adaptation of Teodor to the printing press. This work perfectly agreed with the thematic and ideological guidelines for the renewal of Christian customs and values. The forceful religious and intellectual imposition of the young and learned slave, turned into a “fijadalgo” in the …

Pharmacogenetic Study of ABCB1 and CYP3A5 Genes During the First Year Following Heart Transplantation Regarding Tacrolimus or Cyclosporine Levels

2011

Pharmacogenetics explains part of the interindividual variability in drug responses. Many published works about the effects of single nucleotide polymorphisms (SNPs) on immunosuppressive drug blood levels present contradictory results. We evaluated the SNPs in ABCB1 (glycoprotein P) and CYP3A5 (metabolic enzyme) genes, seeking correlate them with tacrolimus or cyclosporine levels during the first year after heart transplantation. One blood sample was obtained from each of 41 patients: 26 treated with cyclosporine and 15 with tacrolimus. We characterize the SNPs rs1045642, 1128503, 2032582, 2235013, 2235033, 2229109, 3213619, 9282564 in ABCB1 and rs10264272, 776746 in CYP3A5 genes using the …

Rho protein inhibition blocks protein kinase C translocation and activation.

1998

Small GTP-binding proteins of the Ras and Rho family participate in various important signalling pathways. Large clostridial cytotoxins inactivate GTPases by UDP-glucosylation. Using Clostridium difficile toxin B-10463 (TcdB) for inactivation of Rho proteins (RhoA/Rac/Cdc42) and Clostridium sordellii lethal toxin-1522 (TcsL) for inactivation of Ras-proteins (Ras/Rac/Ral, Rap) the role of these GTPases in protein kinase C (PKC) stimulation was studied. Phorbol-myristate-acetate (PMA) induced a rapid PKC translocation to and activation in the particulate cell fraction as determined by PKC-activity measurements and Western blots for PKC alpha. These effects were blocked by TcdB inhibiting Rho …