Search results for "Clos"
showing 10 items of 1439 documents
The Role of Striated Sphincter Muscle in Urethral Closure Under Stress Conditions: An Experimental Study
1987
Decisive for urethral closure under stress is an increase in intraurethral pressure. This pressure increase is significantly affected by urethral tonus, passive pressure transmission and reflex pressure transmission. Approximately half of the urethral tonus is produced by the striated sphincter muscles (Rud et al. 1981; Tanagho 1979).
$V$-filtrations in positive characteristic and test modules
2013
Let $R$ be a ring essentially of finite type over an $F$-finite field. Given an ideal $\mathfrak{a}$ and a principal Cartier module $M$ we introduce the notion of a $V$-filtration of $M$ along $\mathfrak{a}$. If $M$ is $F$-regular then this coincides with the test module filtration. We also show that the associated graded induces a functor $Gr^{[0,1]}$ from Cartier crystals to Cartier crystals supported on $V(\mathfrak{a})$. This functor commutes with finite pushforwards for principal ideals and with pullbacks along essentially \'etale morphisms. We also derive corresponding transformation rules for test modules generalizing previous results by Schwede and Tucker in the \'etale case (cf. ar…
Gamificación en el aula: una experiencia de “escape room inversa”
2021
<p class="Abstract">El recurso de la enseñanza a través del juego (gamificación) se ha ido extendiendo también a la docencia en la Universidad, con buenos resultados. En este trabajo presentamos una enriquecedora experiencia de gamificación en el aula, realizada en las asignaturas Estadística II, del Grado en Finanzas y Contabilidad, de la Universitat de València y Matemáticas 1, del Grado en Fundamentos de la Arquitectura de la Universitat Politècnica de València.</p><p class="Abstract">La denominamos “escape room inversa”, en referencia a que nuestra actividad lúdica consistió, a diferencia de la actividad de ocio popularmente conocida, en lograr volver a un espacio cerr…
Performance analysis of the closed loop supply chain
2012
Purpose The question of resource scarcity and emerging pressure of environmental legislations has brought a new challenge for the manufacturing industry. On the one hand, there is a huge population that demands a large quantity of commodities; on the other hand, these demands have to be met by minimum resources and pollution. Resource conservative manufacturing (ResCoM) is a proposed holistic concept to manage these challenges. The successful implementation of this concept requires cross functional collaboration among relevant fields, and among them, closed loop supply chain is an essential domain. The paper aims to highlight some misconceptions concerning the closed loop supply chain, to d…
GD3 ganglioside directly targets mitochondria in a bcl-2-controlled fashion.
2000
Lipid and glycolipid diffusible mediators are involved in the intracellular progression and amplification of apoptotic signals. GD3 ganglioside is rapidly synthesized from accumulated ceramide after the clustering of death-inducing receptors and triggers apoptosis. Here we show that GD3 induces dissipation of DeltaPsim and swelling of isolated mitochondria, which results in the mitochondrial release of cytochrome c, apoptosis inducing factor, and caspase 9. Soluble factors released from GD3-treated mitochondria are sufficient to trigger DNA fragmentation in isolated nuclei. All these effects can be blocked by cyclosporin A, suggesting that GD3 is acting at the level of the permeability tran…
Evaluation of Changes in Gut Microbiota in Patients with Crohn’s Disease after Anti-Tnfα Treatment: Prospective Multicenter Observational Study
2020
Background: Crohn’s disease is believed to result from the interaction between genetic susceptibility, environmental factors and gut microbiota, leading to an aberrant immune response. The objectives of this study are to evaluate the qualitative and quantitative changes in the microbiota of patients with Crohn’s disease after six months of anti-tumor-necrosis factor (anti-TNFα) (infliximab or adalimumab) treatment and to determine whether these changes lead to the recovery of normal microbiota when compared to a control group of healthy subjects. In addition, we will evaluate the potential role of the Faecalibacterium prausnitzii/Escherichia coli and Faecalibacterium prausnitzii/Clostridium…
The spatial evaluation of the radiative human body heat exchanges: An effective contribution for limiting energy consumption and achieving better ind…
2018
Abstract Radiative heat exchanges inside buildings remarkably affect the thermal balance of the human body in confined spaces and the related thermal comfort sensations of people. The mean radiant temperature is an important component of this balance. Unfortunately, it is usually computed by means of too simplified relationships, which significantly influence the comfort evaluations. Such simplified approaches are also accountable for a less effective design of HVAC systems which, in turn, could result in high energy consumption in the climatization of buildings. However, an accurate evaluation of the mean radiant temperature, especially when high intensity sources are present in a given in…
Direct evidence that FK506 inhibition of FcεRI-mediated exocytosis from RBL mast cells involves calcineurin
1998
eRI-mediated exocytosis of preformed mediators from mast cells and basophils (e.g. histamine, serotonin, beta-hexosaminidase) is sensitive to the immunosuppressants cyclosporin A and FK506 (IC 50 200 and 4 n M , respectively) but not rapamycin. The mechanism of inhibition does not appear to involve tyrosine phosphorylation, hydrolysis of inositol phosphates or calcium flux. Here we report experiments using a molecular approach to assess the role of calcineurin, a serine/threonine phosphatase thought to be the primary pharmacological target of these drugs. Calcineurin’s activity requires association of its catalytic (A) subunit with an intrinsic regulatory (B) subunit. We hypothesized that c…
Three-dimensional structure of the anaphase-promoting complex.
2001
The anaphase-promoting complex (APC) is a cell cycle-regulated ubiquitin-protein ligase, composed of at least 11 subunits, that controls progression through mitosis and G1. Using cryo-electron microscopy and angular reconstitution, we have obtained a three-dimensional model of the human APC at a resolution of 24 A. The APC has a complex asymmetric structure 140 A x 140 A x 135 A in size, in which an outer protein wall surrounds a large inner cavity. We discuss the possibility that this cavity represents a reaction chamber in which ubiquitination reactions take place, analogous to the inner cavities formed by other protein machines such as the 26S proteasome and chaperone complexes. This cag…
Proteomics of CaCO3 biomineral-associated proteins: how to properly address their analysis.
2013
8 pages; International audience; In a recent editorial (Proc. Natl. Acad. Sci., 2013 110, E2144-E2146) and elsewhere, questions have been raised regarding the experimental practices in relation to the proteomic analysis of organic matrices associated to the biomineralized CaCO3 skeletons of metazoans such as molluscan shells and coral skeletons. Indeed, although the use of new high sensitivity MS technology potentially allows to identify a greater number of proteins, it is also equally (or even more) sensitive to contamination of residual proteins from soft tissues, which are in close contact with the biomineral. Based on our own past and present experimental know-how-observations that are …