Search results for "Clos"
showing 10 items of 1439 documents
Clostridium difficile toxin A induces expression of the stress-induced early gene product RhoB.
2004
Clostridium difficile toxin A monoglucosylates the Rho family GTPases Rho, Rac, and Cdc42. Glucosylation leads to the functional inactivation of Rho GTPases and causes disruption of the actin cytoskeleton. A cDNA microarray revealed the immediate early gene rhoB as the gene that was predominantly up-regulated in colonic CaCo-2 cells after treatment with toxin A. This toxin A effect was also detectable in epithelial cells such as HT29 and Madin-Darby canine kidney cells, as well as NIH 3T3 fibroblasts. The expression of RhoB was time-dependent and correlated with the morphological changes of cells. The up-regulation of RhoB was approximately 15-fold and was based on the de novo synthesis of …
"I RIFLESSI STRATEGICI ORGANIZZATIVI E CONTABILI DEI PRINCIPI CONTABILI INTERNAZIONALI NELLE IMPRESE BANCARIE"
2008
Questo lavoro fornisce una prima ricognizione degli effetti che l’adozione dei principi contabili internazionali da parte delle imprese bancarie ha comportato, da un punto di vista sia strettamente contabile sia organizzativo. In particolare, sono stati oggetto di analisi i principi che disciplinano il trattamento contabile e la disclosure delle voci di bilancio di natura finanziaria, e quindi i principi IAS 32, IAS 39 e IFRS 7. Nella prima parte del lavoro sono state esposte le principali novità introdotte da questi principi, dando particolare rilievo al criterio del fair value ed al diverso trattamento previsto per gli strumenti derivati rispetto alla precedente prassi contabile. Nella se…
Impact of probiotic Saccharomyces boulardii on the gut microbiome composition in HIV-treated patients: A double-blind, randomised, placebo-controlled…
2017
Dysbalance in gut microbiota has been linked to increased microbial translocation, leading to chronic inflammation in HIV-patients, even under effective HAART. Moreover, microbial translocation is associated with insufficient reconstitution of CD4+T cells, and contributes to the pathogenesis of immunologic non-response. In a double-blind, randomised, placebo-controlled trial, we recently showed that, compared to placebo, 12 weeks treatment with probiotic Saccharomyces boulardii significantly reduced plasma levels of bacterial translocation (Lipopolysaccharide-binding protein or LBP) and systemic inflammation (IL-6) in 44 HIV virologically suppressed patients, half of whom (n = 22) had immun…
Restoration of two small Mediterranean lagoons: The dynamics of submerged macrophytes and factors that affect the success of revegetation
2013
Abstract Two small, shallow lagoons newly created from former rice fields in the Mediterranean coast (Albufera de Valencia Natural Park, Spain) were restored by planting several species of submerged macrophytes (Myriophyllum spicatum, Ceratophyllum demersum, Potamogeton spp., Zannichellia peltata and Ranunculus peltatus) in 2008. Charophytes also appeared spontaneously. M. spicatum was the species that dominated both lagoons and almost completely covered their surface. M. spicatum reached a high biomass and displayed a seasonal pattern, declining during the cold season and reappearing in the spring. No submerged vegetation was observed in the lagoons from 2011 onward. The major purpose of t…
Free differential Galois groups
2019
We study the structure of the absolute differential Galois group of a rational function field over an algebraically closed field of characteristic zero. In particular, we relate the behavior of differential embedding problems to the condition that the absolute differential Galois group is free as a proalgebraic group. Building on this, we prove Matzat's freeness conjecture in the case that the field of constants is algebraically closed of countably infinite transcendence degree over the rationals. This is the first known case of the twenty year old conjecture.
Cyclicity of Triassic to Lower Jurassic continental red beds of the Argana Valley, Morocco: implications for palaeoclimate and basin evolution
2000
Abstract Cyclical playa deposits form a prominent part of the continental clastic succession of the Argana Valley, Western High Atlas of Morocco. The red beds formed in Triassic to Lower Jurassic times during rifting of the North American and African plates. Detailed stratigraphic work revealed asymmetrical, metre-scale cycles in mudstone-dominated successions that constitute the intermediate and upper portion of the basin fill. Sedimentary cycles commonly comprise ephemeral lake shales at the base, playa mudflat mudstones in the intermediate part, and both fluvial and aeolian sandstones at the top. Cycles of the Aglegal Member (T4) are mainly characterized by analcime-rich playa mudflat de…
3D Reconstruction of Dynamic Vehicles using Sparse 3D-Laser-Scanner and 2D Image Fusion
2016
International audience; Map building becomes one of the most interesting research topic in computer vision field nowadays. To acquire accurate large 3D scene reconstructions, 3D laser scanners are recently developed and widely used. They produce accurate but sparse 3D point clouds of the environments. However, 3D reconstruction of rigidly moving objects along side with the large-scale 3D scene reconstruction is still lack of interest in many researches. To achieve a detailed object-level 3D reconstruction, a single scan of point cloud is insufficient due to their sparsity. For example, traditional Iterative Closest Point (ICP) registration technique or its variances are not accurate and rob…
Rho protein-mediated changes in the structure of the actin cytoskeleton regulate human inducible NO synthase gene expression ☆ ☆This article contains…
2003
Rho proteins (Rho, Rac, Cdc 42) are known to control the organization of the actin cytoskeleton as well as gene expression. Inhibition of Rho proteins by Clostridium difficile toxin B disrupted the F-actin cytoskeleton and enhanced cytokine-induced inducible nitric oxide synthase (iNOS) expression in human epithelial cells. Also specific inhibition by Y-27632 of p160ROCK, which mediates Rho effects on actin fibers, caused a disruption of the actin cytoskeleton and a superinduction of cytokine-induced iNOS expression. Accordingly, direct disruption of the actin cytoskeleton by cytochalasin D, latrunculin B, or jasplakinolide enhanced cytokine-induced iNOS expression. The transcription factor…
Critical success factors for successful globalised e-learning
2009
As we move from an information-based to a knowledge-based society, the need for reengineering, retraining and restructuring is emerging. Online programme development/enhancement requires experience and planning. Since e-learning entry requires little investments, it can be tempting to start programmes without appropriate infrastructure or planning, resulting in huge losses and in many cases closure. The new entrants can learn from the early adopters of online learning and from their experiences, both good and bad without reinventing the wheel. This paper discusses factors that must be considered and planned before venturing into e-learning. These factors are derived from discussions with fa…