Search results for "CoV"
showing 10 items of 9749 documents
Evolutionary advantage conferred by an eukaryote-to-eukaryote gene transfer event in wine yeasts
2015
Although an increasing number of horizontal gene transfers have been reported in eukaryotes, experimental evidence for their adaptive value is lacking. Here, we report the recent transfer of a 158-kb genomic region between Torulaspora microellipsoides and Saccharomyces cerevisiae wine yeasts or closely related strains. This genomic region has undergone several rearrangements in S. cerevisiae strains, including gene loss and gene conversion between two tandemly duplicated FOT genes encoding oligopeptide transporters. We show that FOT genes confer a strong competitive advantage during grape must fermentation by increasing the number and diversity of oligopeptides that yeast can utilize as a s…
Alterations in blood sera metabolome and blood transcriptome in hospitalized COVID-19 patients
2021
COVID-19 pandēmija turpina būt lielākais globālais drauds sabiedrības veselībai, sasniedzot ne tikai apjomīgus infekcijas gadījumu skaitus, bet arī salīdzinoši augstu mirstību starp tiem (~2%). COVID-19 raksturīga heterogēna slimības gaita un šobrīd nav atrasti medikamenti, kas novērš smaga un kritiska stāvokļa iestāšanos. Lai noskaidrotu kādi mehānismi iesaistīti stacionētu COVID-19 pacientu patoģenēzē, tika veikta mērķēta metaboloma un transkriptoma analīze divos laika punktos: pacientam iestājoties slimnīcā un aptuveni 30 dienas vēlāk, tādejādi salīdzinot akūtās fāzes paraugus pret atveseļošanās fāzi. Rezultāti liecina par spēcīgām izmaiņām vairākos metabolajos un imūnsistēmas signālceļo…
Minimizing fleet operating costs for a container transportation company
2006
Abstract This paper focuses on a fleet management problem that arises in container trucking industry. From the container transportation company perspective, the present and future operating costs to minimize can be divided in three components: the routing costs, the resource (i.e., driver and truck) assignment costs and the container repositioning costs (i.e., the costs of restoring a given container fleet distribution over the serviced territory, as requested by the shippers that own the containers). This real-world problem has been modeled as an integer programming problem. The proposed solution approach is based on the decomposition of this problem in three simpler sub-problems associate…
Differences Between Coronavirus-Related Anxiety and Stress Management Strategies in Different Study Programs for Students
2022
Šī bakalaura darba pētījuma mērķis ir izpētīt atšķirības koronovīrusa izraisītās trauksmes rādītājos un stresa pārvarēšanas stratēģijas, psiholoģijas, audiovizuālās mākslas un “deju kolektīva vadītājs” specialitāšu studentiem COVID-19 pandēmijas laikā. Pētījumā piedalījās 89 respondenti no tiem 58 sieviete un 31 vīrieši (65% sievietes, 35% vīrieši), vecumā no 19 līdz 41 gadiem. Izlases visbiežāk sastopamais vecums ir 23 gadi (26%). Pētījumā piedalījās psiholoģijas (23 studenti jeb 26%), audiovizuālās mākslas (28 studenti jeb 31%) un “deju kolektīva vadītājs” (38 studenti jeb 43%) specialitāšu studenti. Pētījumā tika izmantoti divi instrumenti. Koronavīrusa trauksmes rādītāju noskaidro…
ESSAI RANDOMISÉ POUR ÉVALUER L’EFFICACITÉ ET LA SÉCURITÉ DE TRAITEMENTS CHEZ DES PATIENTS AMBULATOIRES ATTEINTS DE COVID-19 AYANT DES FACTEURS DE RIS…
2021
Context. The Covid-19 pandemic is of unprecedented magnitude and has had major social and health consequences. Primary care professionals, mainly general practitioners, ensure the care of most patients with Covid-19. An early-stage treatment administered to patients with risk factors for developing a severe disease could reduce hospitalization and death rates. No treatment is currently validated in this indication. Objectives. To evaluate the safety and efficacy of experimental candidate agents delivered in outpatient settings to reduce the risk of hospitalization or death in at-risk patients with early-stage proven Covid-19 and no indication for hospital admission. Methods. Multicentric, o…
Dipeptidyl Enoates As Potent Rhodesain Inhibitors That Display a Dual Mode of Action
2015
Dipeptidyl enoates were prepared through a high-yielding two-step synthetic route. They have a dipeptidic structure with a 4-oxoenoate moiety as a warhead with multiple reactive sites. Dipeptidyl enoates were screened against rhodesain and human cathepsins B and L, and were found to be potent and selective inhibitors of rhodesain. Among them (S,E)-ethyl 5-((S)-2-{[(benzyloxy)carbonyl]amino}-3-phenylpropanamido)-7-methyl-4-oxooct-2-enoate (6) was the most potent, with an IC50 value of 16.4 nm and kinact/Ki=1.6×106 m−1 s−1 against rhodesain. These dipeptidyl enoates display a reversible mode of inhibition at very low concentrations and an irreversible mode at higher concentrations. Inhibition…
Kriisinkestävä koulu
2022
Meitä edelleen kiusaavan pandemian alettua suomalainen yhteiskunta pysähtyi tai joutui muuttamaan käytäntöjään monella toiminta-alueella. Yksi koko yhteiskuntaa heijasteleva toiminta-alue oli koululaitos eri tasoillaan. Marja-Kristiina Lerkkanen tarkastelee artikkelissaan tuoreisiin tutkimustuloksiin perustuen opettajien työn ja työtilanteen muuttumista ja sen heijastumista niin oppilaisiin kuin koko koulun toimintaan. Esiin nousevat koulujen ja kotien resurssit selvitä muuttuneessa tilanteessa sekä täysin uudesta tilanteesta saatavat opit tulevaisuutta ajatellen. nonPeerReviewed
Income and Career Concerns Among Emerging Adults From Finland, Sweden, and the United Kingdom During COVID-19
2023
In this study, we examine the prevalence of income and career concerns among emerging adults in three different welfare states during COVID-19: Finland ( n = 309), Sweden ( n = 324), and the United Kingdom ( n = 343). This study also delves into how factors such as one’s self-perceived financial situation, generalized mistrust, loneliness and socio-demographics are related to emerging adults’ income and career concerns. Results showed that individuals from the United Kingdom were more likely to experience increased income and career concerns than those in Finland and Sweden. Our results also suggest that income concerns were associated with one’s current financial situation, future financi…
An evaluation of cool season turfgrassess in order to identify the species and varieties most suitable for the Mediterranean environment
2004
The cultivars of cool season Graminae species diffusely used to establish turfgrasses, are grown in northern areas of Europe. The aim of the research described in this paper was to identify the turfgrass species and cultivars most suitable for the Mediterranean environment. The trial was carried out in 1999 and 2000 at the experimental farm “Parco d’Orleans” belonging to the Department A.C.E.P. of University of Palermo. During the trial sixty different cultivars of cool season turf species were compared – 20 cultivars of Festuca arundinacea Schreb., 20 cultivars of Poa pratensis L., and 20 cultivars of Lulium perenne L. The main biometric and qualitative parameters examined were ground cove…
Digitalisaation vaikutukset työhyvinvointiin ja työtyytyväisyyteen
2021
Digitalisaatiota, työhyvinvointia ja työtyytyväisyyttä on tutkittu paljon. COVID -19 muutti työntekoa ja suurin osa työntekijöistä joutui siirtymään lyhyessä ajassa etätyöhön. Etätyöskentely on puolestaan nostanut esiin uusia työhyvin vointiin ja työtyytyväisyyteen liittyviä seikkoja. Olemme siirtyneet uudelle aika kaudelle työnteossa ja etätyöstä on tullut uusi normaali. Tämän tutkimuksen ai heena oli työn digitalisaatio ja etätyöskentely. Tutkimuskysymyksenä oli, miten työn digitalisaatio on vaikuttanut työhyvinvointiin ja työtyytyväisyyteen? Tutki muskysymykseen vastattiin käyttämällä tutkimusmetodina kirjallisuuskatsausta, jossa käytiin läpi lukuisia aineistoja, joissa oli käsitelty työ…