Alterations in blood sera metabolome and blood transcriptome in hospitalized COVID-19 patients

6533b7dafe1ef96bd126e570

RESEARCH PRODUCT

Alterations in blood sera metabolome and blood transcriptome in hospitalized COVID-19 patients

subject

transkriptoms SARS-CoV-2 COVID-19 Bioloģija metaboloms

description

COVID-19 pandēmija turpina būt lielākais globālais drauds sabiedrības veselībai, sasniedzot ne tikai apjomīgus infekcijas gadījumu skaitus, bet arī salīdzinoši augstu mirstību starp tiem (~2%). COVID-19 raksturīga heterogēna slimības gaita un šobrīd nav atrasti medikamenti, kas novērš smaga un kritiska stāvokļa iestāšanos. Lai noskaidrotu kādi mehānismi iesaistīti stacionētu COVID-19 pacientu patoģenēzē, tika veikta mērķēta metaboloma un transkriptoma analīze divos laika punktos: pacientam iestājoties slimnīcā un aptuveni 30 dienas vēlāk, tādejādi salīdzinot akūtās fāzes paraugus pret atveseļošanās fāzi. Rezultāti liecina par spēcīgām izmaiņām vairākos metabolajos un imūnsistēmas signālceļos, tai skaitā par pastriprinātu triptofāna katabolismu kinureīna ceļā, komplementa sistēmas aktivāciju un neitrofilu tīklu veidošanos.

year	journal	country	edition	language
2021-01-01

https://dspace.lu.lv/dspace/handle/7/54487

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