Search results for "metaboloms"

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Alterations in blood sera metabolome and blood transcriptome in hospitalized COVID-19 patients

2021

COVID-19 pandēmija turpina būt lielākais globālais drauds sabiedrības veselībai, sasniedzot ne tikai apjomīgus infekcijas gadījumu skaitus, bet arī salīdzinoši augstu mirstību starp tiem (~2%). COVID-19 raksturīga heterogēna slimības gaita un šobrīd nav atrasti medikamenti, kas novērš smaga un kritiska stāvokļa iestāšanos. Lai noskaidrotu kādi mehānismi iesaistīti stacionētu COVID-19 pacientu patoģenēzē, tika veikta mērķēta metaboloma un transkriptoma analīze divos laika punktos: pacientam iestājoties slimnīcā un aptuveni 30 dienas vēlāk, tādejādi salīdzinot akūtās fāzes paraugus pret atveseļošanās fāzi. Rezultāti liecina par spēcīgām izmaiņām vairākos metabolajos un imūnsistēmas signālceļo…

transkriptomsSARS-CoV-2COVID-19Bioloģijametaboloms

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PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
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LSLife Sciences
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