Search results for "Coco"

Il rococò a Valencia e la sua applicazione nell’adorno architettonico

2019

Riassunto: Il Rococò si manifestò nella città di Valencia durante il trentennio centrale del Settecento e si espresse in tutte le forme dell’arte. Raggiunse l’apice della sua ricchezza nella decorazione degli interni, primi tra tutti quelli del palazzo de Dos Aguas e della vicina chiesa di San Andrés. Il suo successo cessò con l’avvento dell’Accademismo, che con l’istituzione della Reale Accademia di Belle Arti di San Carlos nel 1768, pretese il controllo delle arti sotto il segno del neoclassicismo. Si è sempre relegato il Rococò nelle ultime pagine dell’evoluzione del Barocco valenzano e manca uno studio indipendente del Rococò valenciano, delle sue fonti stilistiche, dei modelli che impi…

MUC1-CT mediates corticosteroid responses in COPD

2016

Background: Corticosteroid resistance is an acquired condition in chronic obstructive pulmonary disease (COPD) patients and a challenge to develop new anti-inflammatory therapies. In previous reports we showed that cytoplasmic tail of the membrain tethered mucin 1 (MUC1-CT) interacts with glucocorticoid receptor (GR) mediating corticosteroid anti-inflammatory efficacy. Objectives: To analyze the role of MUC1-CT as a key marker of corticosteroid efficacy in COPD Methods: The expression of MUC1-CT and the anti-inflammatory role of dexamethasone were evaluated in neutrophils and bronchial epithelial cells from healthy and COPD patients. Anti-inflammatory effects of dexamethasone and glucocorti…

Evaluation of strawberry cultivars in soilless cultivation in Sicily

2008

Predatory habits of the grasshopper-hunting waspStizus continuus(Hymenoptera: Crabronidae): diet preference, predator–prey size relationships and for…

2009

In a coastal salt-marsh of Spain, the digger wasp Stizus continuus primarily hunted for grasshoppers of the genus Heteracris, revealing (at least in the period of the study and in this area) this wasp to be almost monophagous. In contrast, grasshoppers of the genus Acrotylus were ignored by the wasps in spite of their high abundance in the environment. We hypothesize that this bias occurred because Acrotylus is found more often on the soil and on grasses, while Heteracris is nearly only found on Sarcocornia bushes, which probably represent the habitat mostly exploited by the wasps for hunting. The greater variance in size of the prey collected by larger females produced weak wasp–prey size …

Metabolic comorbidities of adrenal insufficiency: Focus on steroid replacement therapy and chronopharmacology

2021

Adrenal insufficiency (AI) is characterized by higher mortality and morbidity compared with the general population. Conventional replacement steroid therapy, currently recommended for the treatment of AI, is associated with increased frequency of metabolic comorbidities due to daily overexposure. By contrast, dual-release hydrocortisone is associated with a decreased risk of metabolic comorbidities, providing an adequate release of hydrocortisone and mimicking the physiological profile of cortisol. These favorable effects are due to a reduced daily steroid exposure that does not affect the expression of the clock genes which are involved in metabolic pathways and are regulated by the normal…

Near-fatal asthma phenotype in the ENFUMOSA Cohort.

2007

Summary Background Near-fatal asthma (NFA) is characterized by severe asthma attacks usually requiring intensive care unit admission. This phenotype of asthma has been studied mainly in acute conditions. Methods The aim of our study was to compare the clinical, functional and inflammatory characteristics of NFA patients with mild to severe asthmatics in stable conditions. We recruited 155 asthmatic patients from five centres of the European Network for Understanding Mechanisms of Severe Asthma: 67 patients with mild-to-moderate asthma controlled by low/medium doses of inhaled corticosteroids; 64 with severe asthma that, despite treatment with high doses of inhaled corticosteroids, long-acti…

The Relationship between COVID-19 and Hypothalamic-Pituitary-Adrenal Axis: A Large Spectrum from Glucocorticoid Insufficiency to Excess-The CAPISCO I…

2022

Coronavirus disease 2019 (COVID-19) is a highly heterogeneous disease regarding severity, vulnerability to infection due to comorbidities, and treatment approaches. The hypothalamic–pituitary–adrenal (HPA) axis has been identified as one of the most critical endocrine targets of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that might significantly impact outcomes after infection. Herein we review the rationale for glucocorticoid use in the setting of COVID-19 and emphasize the need to have a low index of suspicion for glucocorticoid-induced adrenal insufficiency, adjusting for the glucocorticoid formulation used, dose, treatment duration, and underlying health problems. We a…

Methylprednisolone neutralizes the beneficial effects of erythropoietin in experimental spinal cord injury

2005

Inflammation plays a major pathological role in spinal cord injury (SCI). Although antiinflammatory treatment using the glucocorticoid methyprednisolone sodium succinate (MPSS) improved outcomes in several multicenter clinical trials, additional clinical experience suggests that MPSS is only modestly beneficial in SCI and poses a risk for serious complications. Recent work has shown that erythropoietin (EPO) moderates CNS tissue injury, in part by reducing inflammation, limiting neuronal apoptosis, and restoring vascular autoregulation. We determined whether EPO and MPSS act synergistically in SCI. Using a rat model of contusive SCI, we compared the effects of EPO [500-5,000 units/kg of bod…

Crianças de dois anos de idade como coconstrutoras de cultura

2009

Comment la culture se co-construit-elle au micro-niveau des interactions quotidiennes dans un service d’accueil de la petite enfance? Quelle est cette ‘culture’ construite, qui sont les constructeurs et comment procedent-ils? L’article s’appuie sur une etude de cas portant sur les interactions entre enfants de deux ans. Pour cette etude, des enregistrements-videos ont ete effectues deux fois par mois pendant sept mois dans un service d’accueil, en Finlande. Lors de ces enregistrements, les enfants avaient des objets avec lesquels jouer. Quatre seances ont ete choisies pour l’analyse qualitative. Au cours de la premiere seance, les enfants ont produit une contre-culture aux tentatives de l’e…

Water-saving techniques for restoring desertified lands: some lessons from the field

2022

Nature-based solutions can significantly contribute to restoration projects in areas affected by desertification processes, where they are necessary for reversing land degradation. Currently, one innovative solution is The Cocoon™, which has been designed as a new ecotechnology for improving seedling establishment. The Cocoon consists of a doughnut-shaped container made of recycled cardboard that provides water and shelter at least during the first year of a seedling, which is the most critical for plant establishment. To determine the effectiveness of this ecotechnology under different conditions, the Cocoon was tested on a variety of soils, climates, vegetation, and land uses. Six plantin…