Search results for "Cod"

Accertamento della condizione di assenza di tossicodipendenza nei lavoratori: ruolo del Medico Competente

2008

Secuestro del acetaldehído en la prevención de las recaídas en el alcoholismo : estudios de eficacia preclínica con D-Penicilamina

2013

La Organización Mundial de la Salud sitúa al alcoholismo como una de las patologías más importantes, siendo responsable directa o indirectamente de los elevados costes de la Sanidad en los países industrializados. Su tratamiento a día de hoy es claramente insatisfactorio. En él, la actuación psicoterapéutica a través de diferentes estrategias es complementada, en muchos casos, con una intervención farmacoterapéutica basada en el empleo de unos pocos fármacos que intentan solventar el mayor problema a nivel clínico: las recaídas durante los períodos de abstinencia. Aunque en los últimos años los tratamientos farmacológicos utilizables para la prevención de las recaídas han experimentado un a…

Cost-effective Multiresolution schemes for Shock Computations

2009

Harten's Multiresolution framework has provided a fruitful environment for the development of adaptive codes for hyperbolic PDEs. The so-called cost-effective alternative [4,8,21] seeks to achieve savings in the computational cost of the underlying numerical technique, but not in the overall memory requirements of the code. Since the data structure of the basic algorithm does not need to be modified, it provides a set of tools that can be easily implemented into existing codes and that can be very useful in order to speed up the numerical simulations involved in the testing process that is associated to the development of new numerical schemes.
In this paper we present two different applica…

Molecular and morphological diversity ofTrebouxiamicroalgae in sphaerothallioidCircinariaspp. lichens1

2018

Three vagrant (Circinaria hispida, Circinaria gyrosa, and Circinaria sp. 'paramerae') and one crustose (semi-vagrant, Circinaria sp. 'oromediterranea') lichens growing in very continental areas in the Iberian Peninsula were selected to study the phycobiont diversity. Mycobiont identification was checked using nrITS DNA barcoding: Circinaria sp. 'oromediterranea' and Circinaria sp. 'paramerae' formed a new clade. Phycobiont diversity was analyzed in 50 thalli of Circinaria spp. using nrITS DNA and LSU rDNA, with microalgae coexistence being found in all the species analyzed by Sanger sequencing. The survey of phycobiont diversity showed up to four different Trebouxia spp. as the primary phyc…

The influence of environmental factors on abundance and prevalence of a commensal ostracod hosted by an invasive crayfish: are ‘parasite rules’ relev…

2014

Summary Symbiosis represents a widespread and successful lifestyle, but research on symbiotic associations has been mainly focused on parasites. Three general patterns in parasite ecology have been proposed: (i) aggregation, (ii) positive and tight correlation between mean symbiont abundance and its variance and (iii) positive correlation between abundance and prevalence of symbionts. The factors affecting abundance and prevalence within symbiont species can be grouped into host features and environmental conditions. According to research in parasite ecology, environmental conditions seem to play a minor role. We investigated whether the three most recognised parasite patterns were also evi…

Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted

2006

Abstract Tumours ferment glucose to lactate even in the presence of oxygen (aerobic glycolysis; Warburg effect). The pentose phosphate pathway (PPP) allows glucose conversion to ribose for nucleic acid synthesis and glucose degradation to lactate. The nonoxidative part of the PPP is controlled by transketolase enzyme reactions. We have detected upregulation of a mutated transketolase transcript (TKTL1) in human malignancies, whereas transketolase (TKT) and transketolase-like-2 (TKTL2) transcripts were not upregulated. Strong TKTL1 protein expression was correlated to invasive colon and urothelial tumours and to poor patients outcome. TKTL1 encodes a transketolase with unusual enzymatic prop…

Oxidative stress-mediated alterations in histone post-translational modifications

2021

Abstract Epigenetic regulation of gene expression provides a finely tuned response capacity for cells when undergoing environmental changes. However, in the context of human physiology or disease, any cellular imbalance that modulates homeostasis has the potential to trigger molecular changes that result either in physiological adaptation to a new situation or pathological conditions. These effects are partly due to alterations in the functionality of epigenetic regulators, which cause long-term and often heritable changes in cell lineages. As such, free radicals resulting from unbalanced/extended oxidative stress have been proved to act as modulators of epigenetic agents, resulting in alte…

unitas: the universal tool for annotation of small RNAs

2017

AbstractBackgroundNext generation sequencing is a key technique in small RNA biology research that has led to the discovery of functionally different classes of small non-coding RNAs in the past years. However, reliable annotation of the extensive amounts of small non-coding RNA data produced by high-throughput sequencing is time-consuming and requires robust bioinformatics expertise. Moreover, existing tools have a number of shortcomings including a lack of sensitivity under certain conditions, limited number of supported species or detectable sub-classes of small RNAs.ResultsHere we introduce unitas, an out-of-the-box ready software for complete annotation of small RNA sequence datasets, …

Finnish health care and social work students' perceptions of Finnish-English code-switching : a survey study

2015

Englannin kielen asema kansainvälisenä valtakielenä on vaikuttanut sen leviämiseen myös Suomessa. Laajalle levinnyttä vierasta kieltä käyttävät Suomessa moninaisin tavoin eri-ikäiset ja taitotasoltaan erilaiset ihmiset. Siinä missä vieras kieli oli aiemmin kansakunnan ulkopuolelta tuleva asia, on vieraasta kielestä nykyaikana tullut enenevissä määrin myös yhteiskunnan sisäpuolella käytettävä kielellinen resurssi. Englannin kielen kohtaaminen ja sen käyttäminen ei enää edellytä kansainvälisiä kontakteja tai ulkomaanmatkoja, vaan englantia käytetään sujuvasti myös suomen kieltä äidinkielenään puhuvien kesken, osana pääasiallisesti suomenkielistä keskust…

Funzionamento del codice retorico e contenuti ideologici propri dell’autore: Libanio

2006

Through the internal analysis of Libanius of Antioch's Orations 46, 56 and 57, the work attempted to distinguish between the application and functioning of the rhetorical code and the author's own content, between rhetorical devices and ideological assumptions. The study of the density of rhetorical figures is the method of analysis used to verify the objectivity of the speaker's parrhesia