Search results for "Coi"
showing 10 items of 1683 documents
Data from: Moving in the Anthropocene: global reductions in terrestrial mammalian movements
2019
Animal movement is fundamental for ecosystem functioning and species survival, yet the effects of the anthropogenic footprint on animal movements have not been estimated across species. Using a unique GPS-tracking database of 803 individuals across 57 species, we found that movements of mammals in areas with a comparatively high human footprint were on average one-half to one-third the extent of their movements in areas with a low human footprint. We attribute this reduction to behavioral changes of individual animals and to the exclusion of species with long-range movements from areas with higher human impact. Global loss of vagility alters a key ecological trait of animals that affects no…
Aldosterone synthase activity in the Y-1 adrenal cell line.
1995
The Y-1 adrenal cell line was shown to produce 20 alpha-dihydroaldosterone from deoxycorticosterone. This compound was identified by GC-MS by comparison with the previously synthesized reference compound. Two other 18-hydroxylated metabolites were identified as 11 beta,18-dihydroxy-20 alpha-dihydroprogesterone from endogenous cholesterol and 18-hydroxy-20 alpha-dihydro-11-dehydrocorticosterone from DOC. The conditions necessary for the synthesis of these compounds are culturing in 20% serum-supplemented medium and repeated incubations with the substrate. The production of 11 beta-hydroxylated steroids and that of 18-oxygenated steroids is stimulated differently by ACTH and angiotensin II su…
Synthesis of tritium labeled 7α-methoxycarbonyl-15β,16β-methylene-3-oxo-17α-pregn-4-ene-21, 17-carbolactone, [3H]SH-D515, a highly selective tracer f…
1988
The synthesis of 7α-methoxycarbonyl-15β,16β-methylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone (5, SH-D515, ZK 91587), a potent aldosterone antagonist exhibiting a strong and very selective binding to the mineralocorticoid receptor and the tritiated analog 6 is reported.
A coincidence-point problem of Perov type on rectangular cone metric spaces
2017
We consider a coincidence-point problem in the setting of rectangular cone metric spaces. Using alpha-admissible mappings and following Perov's approach, we establish some existence and uniqueness results for two self-mappings. Under a compatibility assumption, we also solve a common fixed-point problem.
Geometric interpretation of the optimality conditions in multifacility location and applications
1991
Geometrical optimality conditions are developed for the minisum multifacility location problem involving any norm. These conditions are then used to derive sufficient conditions for coincidence of facilities at optimality; an example is given to show that these coincidence conditions seem difficult to generalize.
Mucosal immunoregulation: transcription factors as possible therapeutic targets.
2005
Much progress has been recently made with regard to our understanding of the mucosal immune system in health and disease. In particular, it has been shown that uncontrolled mucosal immune responses driven by lymphocytes or non-lymphoid cells may lead to immunological diseases such as allergy, hypersensitivity and inflammation. Thus, a more detailed understanding of mucosal immune regulation and decision making at mucosal surfaces is essential for a better understanding of mucosal immune responses in health and disease. Antigen presenting cells and T lymphocytes play a key role in controlling mucosal immune responses. To deal with this key task, T helper cells differentiate into functionally…
Electromechanical Numerical Analysis of an Air-Core Pulsed Alternator via Equivalent Network Formulation
2017
In this paper, the numerical analysis on an air-core pulsed alternator is presented. Since compulsators are characterized by very fast electromechanical transients, their accurate analysis requires strong coupling between the equations governing the electrical and the mechanical behaviors. The device is investigated by using a dedicated numerical code capable to take into account eddy currents, compensating windings, as well as the excitation/control circuits. Furthermore, the code is capable of modeling centrifugal forces and vibrations acting on the shaft due to electric and mechanical unbalances or to misalignments of the shaft from its centered position. This makes the code a very power…
Effects of ACE-Inhibitors and Angiotensin Receptor Blockers on Inflammation
2011
The role of inflammation in cardiovascular disease and in hypertensive disease above all, is complex. Several studies confirm that activation of renin-angiotensin-aldosterone system (RAAS), through increase in the production of angiotensin II (Ang II), is closely related to local vascular inflammation. Over the BP lowering effects of anti-hypertensive treatments, several ancillary effects for every class may be found, distinguishing the various drugs from one another. Given the pro-inflammatory effects of Ang II and aldosterone, agents that interfere with the components of RAAS, such as ACE inhibitors, Angiotensin Receptor Blockers (ARBs), and mineralocorticoid receptor antagonists (spirono…
Positron preferential annihilation in Bi-Sb alloys
2009
We report the measurements of the positron annihilation characteristics, i.e., positron lifetime and coincidence Doppler broadening spectra performed on five Bi-Sb alloys having a Bi content between 12.5 and 81 at.%. The strong effect of the preferential annihilation of positrons with the electrons of the Bi atoms has been revealed in these alloys.
Calibration and survey of AMANDA with the SPASE detectors
2004
We report on the analysis of air showers observed in coincidence by the Antarctic Muon and Neutrino detector array (AMANDA-B10) and the South Pole Air Shower Experiment (SPASE-1 and SPASE-2). We discuss the use of coincident events for calibration and survey of the deep AMANDA detector as well as the response of AMANDA to muon bundles. This analysis uses data taken during 1997 when both SPASE-1 and SPASE-2 were in operation to provide a stereo view of AMANDA. © 2003 Elsevier B.V. All rights reserved.