Search results for "Coliti"

Oleuropein protects against dextran sodium sulfate-induced chronic colitis in mice.

2013

The anti-inflammatory effect of oleuropein (1), the major phenolic secoiridoid in Olea europaea, was evaluated in an experimental model of chronic colitis in mice. Animals were exposed to four repeated cycles of dextran sodium sulfate in drinking water followed by a 7-day rest period. Animals receiving a standard diet supplemented with 0.25% of 1 (equivalent to 500 mg/kg/day) for 56 days exhibited a decrease of inflammatory symptoms, as reflected by improvement of disease activity index and histopathological changes. It was found that 1 decreased inflammatory cell recruitment and the release of inflammatory cytokines interleukin (IL)-1β and IL-6 with increased IL-10 levels in colon tissue. …

Cutting Edge: IL-23 Cross-Regulates IL-12 Production in T Cell-Dependent Experimental Colitis

2006

Abstract Although IL-12 and IL-23 share the common p40 subunit, IL-23, rather than IL-12, seems to drive the pathogenesis of experimental autoimmune encephalomyelitis and arthritis, because IL-23/p19 knockout mice are protected from disease. In contrast, we describe in this study that newly created LacZ knockin mice deficient for IL-23 p19 were highly susceptible for the development of experimental T cell-mediated TNBS colitis and showed even more severe colitis than wild-type mice by endoscopic and histologic criteria. Subsequent studies revealed that dendritic cells from p19-deficient mice produce elevated levels of IL-12, and that IL-23 down-regulates IL-12 expression upon TLR ligation. …

Adaptation of TECCU App Based on Patients´ Perceptions for the Telemonitoring of Inflammatory Bowel Disease: A Qualitative Study Using Focus Groups

2020

Background: Despite the continuous adaptation of eHealth systems for patients with inflammatory bowel disease (IBD), a significant disconnection persists between users and developers. Since non-adherence remains high, it is necessary to better understand the patients&rsquo

Efecte protector dels compostos fenòlics àcid el·làgic, apocinina i rutina en el tractament de la colitis ulcerosa induïda per dextranosulfat sòdic

2014

L’ús de productes naturals entre aquells pacients que pateixen malalties cròniques s’inclou dins de les opcions més emprades dels tractaments complementaris i/o alternatius a la medicina convencional. Entre els constituents naturals d'origen vegetal amb interès terapèutic destaquen els compostos fenòlics, alguns dels quals han demostrat ser efectius en el tractament de la colitis ulcerosa (CU). Aquesta malaltia, d’etiologia desconeguda, es caracteritza per una inflamació del còlon que afecta la mucosa des del recte fins a la seua totalitat. El present treball ha abordat l’avaluació de les propietats protectores de tres compostos amb estructura fenòlica -àcid el·làgic, apocinina i rutina-, i…

Papel de la ecoendoscopia previa a la CPRE ante la sospecha de coledocolitiasis

2017

RESUMEN PROYECTO TESIS DOCTORAL. Autor: Ana Belén Durá Ayet. Título Provisional del proyecto de tesis: Papel de la ecoendoscopia previa a la CPRE ante la sospecha de coledoolitiasis. Tema. La Colangiopancreatografía retrógrada endoscópica (CPRE) ha sido considerada durante muchos años la técnica de elección en el diagnóstico preoperatorio de la coledocolitiasis, sin embargo se asocia a una tasa nada despreciable de complicaciones como riesgo de pacreatitis, hemorragias y perforación que se estima entre un 2-20% según las series. El avance tecnológico ha permitido obtener mediante otras técnicas no invasivas (Colangiopancreatografía por resonancia magnética-CPRM) o mínimamente invasivas (Ult…

The Effect of Probiotics in The Therapy of Ulcerative Colitis - a clinic study -

VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer.

2010

Inflammation drives expression of VEGFR2, which is expressed on and drives growth of tumor cells in colitis-associated cancer.

Hypoxia Positively Regulates the Expression of pH-Sensing G-Protein–Coupled Receptor OGR1 (GPR68)

2016

Background & Aims: A novel family of proton-sensing G-proteinâcoupled receptors, including ovarian cancer G-proteinâcoupled receptor 1 (OGR1) (GPR68) has been identified to play a role in pH homeostasis. Hypoxia is known to change tissue pH as a result of anaerobic glucose metabolism through the stabilization of hypoxia-inducible factor-1α. We investigated how hypoxia regulates the expression of OGR1 in the intestinal mucosa and associated cells. Methods: OGR1 expression in murine tumors, human colonic tissue, and myeloid cells was determined by quantitative reverse-transcription polymerase chain reaction. The influence of hypoxia on OGR1 expression was studied in monocytes/macrophages and…

Anti-inflammatory Function of High-Density Lipoproteins via Autophagy of IκB Kinase

2015

Background & Aims: Plasma levels of high-density lipoprotein (HDL) cholesterol are frequently found decreased in patients with inflammatory bowel disease (IBD). Therefore, and because HDL exerts anti-inflammatory activities, we investigated whether HDL and its major protein component apolipoprotein A-I (apoA-I) modulate mucosal inflammatory responses in vitro and in vivo. Methods: The human intestinal epithelial cell line T84 was used as the in vitro model for measuring the effects of HDL on the expression and secretion of tumor necrosis factor (TNF), interleukin-8 (IL-8), and intracellular adhesion molecule (ICAM). Nuclear factor-κB (NF-κB)-responsive promoter activity was studied by …

Ambiguous Role of Interleukin-12 in Yersinia enterocolitica Infection in Susceptible and Resistant Mouse Strains

1998

ABSTRACT Endogenous interleukin-12 (IL-12) mediates protection against Yersinia enterocolitica in C57BL/6 mice by triggering gamma interferon (IFN-γ) production in NK and CD4 + T cells. Administration of exogenous IL-12 confers protection against yersiniae in Yersinia -susceptible BALB/c mice but exacerbates yersiniosis in resistant C57BL/6 mice. Therefore, we wanted to dissect the different mechanisms exerted by IL-12 during Yersinia infections by using different models of Yersinia -resistant and -susceptible mice, including resistant C57BL/6 mice, susceptible BALB/c mice, intermediate-susceptible wild-type 129/Sv mice, 129/Sv IFN-γ-receptor-deficient (IFN-γR −/− ) mice and C57BL/6 tumor n…