Search results for "Colon"
showing 10 items of 2038 documents
Does granulocyte-colony stimulating factor stimulate peripheral nerve regeneration? An experimental study on traumatic lesion of the sciatic nerve in…
2021
Aim of the study. To analyse the therapeutic potential of granulocyte-colony stimulating factor (G-CSF) treatment using a rat model of traumatic sciatic nerve lesion. Clinical rationale for the study. G-CSF has proven strong neurotrophic properties in various models of ischaemic and traumatic brain injury. Fewer studies exist regarding the influence of G-CSF on posttraumatic peripheral nerve regeneration. Currently, the possibilities of pharmacological prevention or treatment of mechanical nerve injury are limited, and there is an urgent need to find new treatment strategies applicable in clinical situations. Material and methods . A controlled traumatic right sciatic nerve lesion was set u…
Rôles des cellules myéloïdes suppressives et des infiltrats immunitaires dans le cancer
2013
Immune system plays a dual role in cancer: it can not only suppress tumor growth by destroying cancer cells, but also promote tumor progression by selecting immunoresistant tumor cells or by establishing an immunosuppressive microenvironment. Our main objective is to foster on the context of immune response in colon cancer settingDuring my thesis, I focused on one population of the immunosuppressive cells immune system: MDSC (myeloid derived suppressor cells). In this work, we explored strategies to reduce the number of these cells during tumor growth. We have discovered that small doses of 5 Fluorouracil are able to specifically induce apoptotic death of MDSC. We have characterized a novel…
Tributyltin(Iv) butyrate: A novel epigenetic modifier with er stress-and apoptosis-inducing properties in colon cancer cells
2021
Organotin(IV) compounds are a class of non-platinum metallo-conjugates exhibiting antitumor activity. The effects of different organotin types has been related to several mechanisms, including their ability to modify acetylation protein status and to promote apoptosis. Here, we focus on triorganotin(IV) complexes of butyric acid, a well-known HDAC inhibitor with antitumor properties. The conjugated compounds were synthesized and characterised by FTIR spectroscopy, multi-nuclear (1H, 13C and 119Sn) NMR, and mass spectrometry (ESI-MS). In the triorganotin(IV) complexes, an anionic monodentate butyrate ligand was observed, which coordinated the tin atom on a tetra-coordinated, monomeric enviro…
Des soldats noirs face au Reich: les massacres racistes de 1940
2015
International audience; Une « guerre pour la civilisation » germanique et pour l’Europe blanche : c’est ainsi que les nazis présentaient leur entreprise, qui avait également une dimension de revanche sur la Première Guerre mondiale et sur la « honte noire » infligée par les Français. En effet, depuis les années 1920, racistes et xénophobes allemands ne décoléraient pas : la France avait osé faire occuper le territoire de l’Allemagne par des soldats noirs, issus des troupes coloniales, et les nazis furent les plus virulents à le dénoncer. Lors de la campagne de France, en mai-juin 1940, environ trois mille de ces soldats coloniaux furent en conséquence assassinés, en dehors de toute action d…
Longitudinal analysis of Mycobacterium tuberculosis 19-kDa antigen-specific T cells in patients with pulmonary tuberculosis: association with disease…
2003
CD8(+) T cells play a central role in immune protection against infection with Mycobacterium tuberculosis. One of the target epitopes for anti-M. tuberculosis directed CD8(+) T cells is the HLA-A2-restricted 19-kDa lipoprotein peptide VLTDGNPPEV. T cell clones directed against this epitope recognized not only the nominal peptide ligand, but also a closely related peptide (VPTDPNPPEV) from the HIV envelope gp120 (HIV(env) gp120) protein characterized by IFN-gamma release. This cross-reactivity was confirmed in ex vivo in M. tuberculosis 19-kDa tetramer-sorted T cells from patients with tuberculosis and in HIVgp120 tetramer-reactive T cells sorted from HIV(+) patients. M. tuberculosis 19-kDa …
The relation between tumor cell proliferation and vascularization in differentiated and undifferentiated colon carcinomas in the rat.
1982
Tumor cell proliferation and tumor vascularization were investigated in differentiated and undifferentiated colon carcinomas of the rat. The following results were found: 1, in both tumor types, vascularization is developed equally well; 2, both in the differentiated and in the undifferentiated carcinomas, the number of proliferating tumor cells decreases with increasing distance from the capillaries; at a distance of about 80 microns, there is no longer any noteworthy tumor cell proliferation; 3, the differentiated and undifferentiated carcinomas differ both in the level of the mitosis index and 3H-thymidine labeling index as well as in their local proliferation pattern despite equal vascu…
Transnationalism and Settlement of Latvian Emigrants in the Nordic Countries
2021
The intra-European migration flows have fostered debates about the intentions of migrants to settle in their destination country or return to their countries of origin. Based on a quantitative analysis of survey data ('N' = 1391), this article presents a typology of migration patterns among migrants from Latvia in the Nordic countries. Using two dimensions—attachment to the destination country and attachment to the country of origin—the article identifies and characterises the following four migration patterns: (1) bi-nationals, (2) settlers, (3) footloose migrants and (4) isolated migrants who focus on their country of origin and are willing to return (separated).
Identidad cultural latinoamericana : la mirada heteróclita y la reivindicación del indígena
2020
Se presentan dos perspectivas que buscan definir la concepción de una identidad cultural latinoamericana. La sustentada en el colonialismo heteróclito y, la más actual, de las reivindicaciones indígenas. Ambas han sido preocupaciones recorridas desde el siglo XIX como posibles salidas para un reconocimiento de un ser cultural identificable por cada uno de los fragmentos que conforman los Estados nacionales en América Latina. La reflexión se sustenta en autores como Mariano Picón Salas, José Carlos Mariátegui, Octavio Paz, Roberto Fernández Retamar, Augusto Roa Bastos, Arturo Uslar Pietri, John Beverley, y Ronny Velasquez, entre otros estudiosos de la cultura.
Estepa y rutas de la seda frente al espejo de la Región Autónoma Uigur de Xinjiang. Fronteras fluidas y construcción de narrativas histórico-identita…
2018
La propuesta para este capítulo es la de analizar cómo, a partir de las fronteras imperiales establecidas bajo el período del Gobierno Qing, las poblaciones “bárbaras”/ fronterizas han sido incluidas –más o menos forzosamente– en una definición –más o menos amplia– de “China”. Tras una sucinta introducción histórica sobre el territorio, mi objetivo es el de empezar a hacer hincapié en la influencia, a nivel cultural, lingüístico, identitario y religioso, de la región que –tras su anexión al Imperio Qing– ha pasado a denominarse Xinjiang, en relación con los actores políticos y sociales circunstantes, y tratando de puntualizar unas especificidades históricas de la región, en un contexto eura…
'Viva Alemania': internados alemanes de Camerún en España durante la Primera Guerra Mundial
2019
espanolUn episodio historico poco conocido en el ambito de las relaciones interculturales germano-espanolas y de los procesos migratorios, pero cuyas huellas son todavia palpables en la actualidad, es el de la internacion de la llamada Schutztruppe (fuerza militar colonial alemana) de Camerun en Espana durante la Primera Guerra Mundial. Lo sorprendente en esta situacion de crisis politica se reflejo en el entusiasmo y la admiracion con que fueron recibidos en un primer momento los llamados “internados” alemanes en un pais supuestamente neutral y que se encontraba oficiosamente dividido entre aliadofilos y germanofilos. El ensayo es el resultado de una minuciosa busqueda de las huellas liter…