Search results for "Coloni"

Resectability, conversion, metastasectomy and outcome according to RAS and BRAF status for metastatic colorectal cancer in the prospective RAXO study

2022

Abstract Background Outcomes after metastasectomy for metastatic colorectal cancer (mCRC) vary with RAS and BRAF mutational status, but their effects on resectability and conversion rates have not been extensively studied. Methods This substudy of the prospective RAXO trial included 906 patients recruited between 2011 and 2018. We evaluated repeated centralised resectability assessment, conversion/resection rates and overall survival (OS), according to RAS and BRAF status. Results Patients included 289 with RAS and BRAF wild-type (RAS and BRAFwt), 529 with RAS mutated (RASmt) and 88 with BRAF mutated (BRAFmt) mCRC. Metastatic prevalence varied between the RAS and BRAFwt/RASmt/BRAFmt groups,…

ErbB-3 activation by NRG-1β sustains growth and promotes vemurafenib resistance in BRAF-V600E colon cancer stem cells (CSCs)

2015

Approximately 5-10% of metastatic colorectal cancers harbor a BRAF-V600E mutation, which is correlated with resistance to EGFR-targeted therapies and worse clinical outcome. Vice versa, targeted inhibition of BRAF-V600E with the selective inhibitor PLX 4032 (Vemurafenib) is severely limited due to feedback re-activation of EGFR in these tumors. Mounting evidence indicates that upregulation of the ErbB-3 signaling axis may occur in response to several targeted therapeutics, including Vemurafenib, and NRG-1β-dependent re-activation of the PI3K/AKT survival pathway has been associated with therapy resistance. Here we show that colon CSCs express, next to EGFR and ErbB-2, also significant amoun…

Understanding the clinical behavior of relapsed colon cancers with microsatellite instability relative to BRAF mutations

2019

Background Microsatellite instable/deficient mismatch repair (MSI/dMMR) metastatic colorectal cancers have been reported to have a poor prognosis. Frequent co-occurrence of MSI/dMMR and BRAFV600E complicates the association. Patients and methods Patients with resected stage III colon cancer (CC) from seven adjuvant studies with available data for disease recurrence and MMR and BRAFV600E status were analyzed. The primary end point was survival after recurrence (SAR). Associations of markers with SAR were analyzed using Cox proportional hazards models adjusted for age, gender, performance status, T stage, N stage, primary tumor location, grade, KRAS status, and timing of recurrence. Results A…

Meo iussu et auspicio… Aethiopiam… perventum est (Aug. RG 26, 5). Scenari politico-economici, echi propagandistici e suggestioni espansionistiche del…

2016

Within the constant research of symmetries between the policies of Augustus and Mussolini, although many were the merits of Augustus (the conquest of Ethiopia marked the culmination of the myth of Romanity and the highest level of consensus towards the regime), the military expedition against the ancient Ethiopia (Res Gestae 26), carried out on behalf of Augustus by the prefect of Egypt Publius Petronius : the background of this campaign was a series of events that took place in the decade 30 to 20 B.C. and that can be reconstructed through sources such as Strabo, Pliny the Elder and Cassius Dio, as well as epigraphic evidence. In this specific instance, to find out the real reason of Petro…

A Case of Severe Dyspnea and an Unusual Bronchoscopy: The Chilaiditi Syndrome

2006

Phytochemical Indicaxanthin Inhibits Colon Cancer Cell Growth and Affects the DNA Methylation Status by Influencing Epigenetically Modifying Enzyme E…

2015

<b><i>Background:</i></b> Recently, we have shown anti-proliferative and pro-apoptotic effects of indicaxanthin associated with epigenetic modulation of the onco-suppressor <i>p16</i><sup><i>INK4a</i></sup> in the human colon cancer cell line CACO2. In the present study, the epigenetic activity of indicaxanthin and the mechanisms involved were further investigated in other colorectal cancer cell lines. <b><i>Methods:</i></b> LOVO1, CACO2, HT29, HCT116, and DLD1 cells were used to evaluate the potential influence of consistent dietary concentrations of indicaxanthin on DNA methylation, and the epigenetic mech…

Razzismi, discriminazioni e confinamenti

2013

"Rappresentazioni del corpo del colonizzato, riletture postcoloniali a confronto", Barbara Creed and Jeanette Hoorn (eds.), Body Trade, New York, Rou…

2003

Un'indagine interdisciplinare sulle raffigurazioni del corpo del colonizzato e del prigioniero, nel contesto del colonialismo europeo, in Australia e nel Pacifico, corre sul filo di questa raccolta di saggi, opera di autori di varie nazionalità e diversa formazione. I temi centrali di Body Trade, la mercificazione del corpo dell'Altro e le rappresentazioni del colonizzato, sono dibattuti con l'intento di riesaminare i miti della civiltà occidentale e del cannibalismo, attraverso l'analisi di un vasto repertorio di pratiche coloniali, prese a soggetto di romanzi, riviste, fotografie e film, tutte opere pubblicate lungo un arco temporale che si snoda dal Settecento ai giorni nostri.

Transverstites re-existences: A counterhistory from the visual difference in Peru

2018

El vínculo entre naturaleza y deshumanización es un discurso moderno colonial de género que mantiene su vigencia mediante la basurización simbólica y concreta de quienes son vistos como inferiores, antinaturales y hasta como animales, convertidos en un desecho de la sociedad. Una forma de visualizar al otro como elemento sobrante del sistema simbólico. En este sentido, maniobrar en el campo de la visualidad travesti, sus convenciones y estereotipos, se convierte en una práctica de resistencia en tanto que se enfrenta al régimen escópico eurocéntrico disciplinante, astutamente camuflado. Pero, igualmente, de re-existencia, al proponer la co-presencia visual de la diferencia, y por ende, la e…

The polypyrimidine tract-binding protein (PTB) is involved in the post-transcriptional regulation of human inducible nitric oxide synthase expression.

2006

Human inducible nitric oxide synthase (iNOS) expression is regulated by transcriptional and post-transcriptional mechanisms. We have recently shown that the multifunctional RNA-binding proteins KH-type splicing regulatory protein and tristetraprolin are critically involved in the post-transcriptional regulation of human iNOS expression. Several reports have shown that KH-type splicing regulatory protein colocalizes with the polypyrimidine tract-binding protein (PTB), and both RNA-binding proteins seem to interact with the same mRNAs. Therefore we analyzed the involvement of PTB in human iNOS expression. In human DLD-1 cells, cytokine incubation necessary to induce iNOS expression did not ch…