Search results for "Color"

Entrectinib: a potent new TRK, ROS1, and ALK inhibitor

2015

Abstract: Introduction: Receptor tyrosine kinases (RTKs) and their signaling pathways, control normal cellular processes; however, their deregulation play important roles in malignant transformation. In advanced non-small cell lung cancer (NSCLC), the recognition of oncogenic activation of specific RTKs, has led to the development of molecularly targeted agents that only benefit roughly 20% of patients. Entrectinib is a pan-TRK, ROS1 and ALK inhibitor that has shown potent anti-neoplastic activity and tolerability in various neoplastic conditions, particularly NSCLC. Areas covered: This review outlines the pharmacokinetics, pharmacodynamics, mechanism of action, safety, tolerability, pre-cl…

Color memory in children

2008

The methods of simultaneous and memory color matching have been studied for a set of five Munsell color samples by 50 children, 25 boys and 25 girls (ranging in age from 9 to 11 years). By comparison between this group and one of 50 young adult observers, we can deduce the following: (a) In children, as in young adults, the mean CIELAB total color difference, ΔE*ab, in simultaneous color matching is lower than the ΔE*ab by memory color matching. (b) Children matched reference test worse than young adults for orange, bluish green (only boys and men) and yellow green (only girls and women). (c) While men remember, independently of age and delay time, violet reference test worse than women (P …

Assessment of Classifiers and Remote Sensing Features of Hyperspectral Imagery and Stereo-Photogrammetric Point Clouds for Recognition of Tree Specie…

2018

Recognition of tree species and geospatial information on tree species composition is essential for forest management. In this study, tree species recognition was examined using hyperspectral imagery from visible to near-infrared (VNIR) and short-wave infrared (SWIR) camera sensors in combination with a 3D photogrammetric canopy surface model based on RGB camera stereo-imagery. An arboretum with a diverse selection of 26 tree species from 14 genera was used as a test area. Aerial hyperspectral imagery and high spatial resolution photogrammetric color imagery were acquired from the test area using unmanned aerial vehicle (UAV) borne sensors. Hyperspectral imagery was processed to calibrated …

A new multimodal RGB and polarimetric image dataset for road scenes analysis

2020

International audience; Road scene analysis is a fundamental task for both autonomous vehicles and ADAS systems. Nowadays, one can find autonomous vehicles that are able to properly detect objects present in the scene in good weather conditions but some improvements are left to be done when the visibility is altered. People claim that using some non conventional sensors (infra-red, Lidar, etc.) along with classical vision enhances road scene analysis but still when conditions are optimal. In this work, we present the improvements achieved using polarimetric imaging in the complex situation of adverse weather conditions. This rich modality is known for its ability to describe an object not o…

PO-350 MiRNAs and their relation to biological pathways in left- and right-sided colorectal cancer

2018

Introduction MicroRNAs (miRNAs) are involved in the regulation of gene expression in colorectal cancer (CRC), which has specific biological pathways that are predominant in either left- or right-sided CRC. However, it is unclear how miRNAs are associated with biological pathways in these two forms of CRC. Our hypothesis is that a comprehensive understanding of the fundamental biological signalling pathways in the two sides of CRC may aid in developing a decisive step towards precision medicine. We aim to clarify specific biological pathway differences of differentially expressed miRNAs between left- and right-sided CRC. Material and methods We extracted total RNA from 24 of left- and right-…

Unveiling gene expression regulation of the Bacillus thuringiensis Cry3Aa toxin receptor ADAM10 by the potato dietary miR171c in Colorado potato beet…

2021

Background The Colorado potato beetle (CPB) is a worldwide devastating pest of potato plants and other Solanaceae characterized by its remarkable ability to evolve resistance to insecticides. Bacillus thuringiensis (Bt) Cry3Aa toxin represents an environmentally-safe alternative for CPB control but larvae susceptibility to this toxin has been reported to vary depending on the host plant on which larvae feed. To gain more insight into how nutrition mediates Bt tolerance through effects on gene expression here we explored the post-transcriptional regulation by miRNAs of the CPB-ADAM10 gene encoding the Cry3Aa toxin functional receptor ADAM10. Results The lower CPB-ADAM10 gene expression in CP…

Endoscopic rendezvous in stricture of colorectal anastomosis: A new approach

2013

The actual management of colorectal liver metastases

2020

Colorectal cancer is one of the most frequent cancers in the world and between 50% and 60% of patients will develop colorectal liver metastases (CRLM) during the disease. There have been great improvements in the management of CRLM during the last decades. The combination of modern chemotherapeutic and biological systemic treatments with aggressive surgical resection strategies is currently the base for the treatment of patients considered unresectable until few years ago. Furthermore, several new treatments for the local control of CRLM have been developed and are now part of the arsenal of multidisciplinary teams for the treatment of these complex patients. The aim of this review was to s…

Review of the chromatic subjects about image capture (II)

2002

Este trabajo aborda la problemática general de la reproducción del color que se genera en dispositivos de captura (escáneres y cámaras). Se expuso en la primera parte de este trabajo que los dispositivos de captura no son directamente instrumentos de medida del color debido a la opción tecnológica sistemáticamente usada en el diseño de sus sensibilidades espectrales. Por tanto, se estudian en esta segunda sección las opciones posibles de transformación de color o perfil colorimétrico entre el espacio RGB dependiente de estos dispositivos y el espacio estándar CIE-1931 XYZ. Esto conlleva a su vez una revisión de los algoritmos existentes para evaluar el grado de exactitud colorimétrica conse…

Positive family history of colorectal cancer in a general practice setting [FRIDA.Frankfurt]: study protocol of a of a cross-sectional study.

2015

Background Although the risk of developing colorectal cancer (CRC) is 2-4 times higher in case of a positive family history, risk-adapted screening programs for family members related to CRC- patients do not exist in the German health care system. CRC screening recommendations for persons under 55 years of age that have a family predisposition have been published in several guidelines. The primary aim of this study is to determine the frequency of positive family history of CRC (1st degree relatives with CRC) among 40–54 year old persons in a general practitioner (GP) setting in Germany. Secondary aims are to detect the frequency of occurrence of colorectal neoplasms (CRC and advanced adeno…