Search results for "Color"
showing 10 items of 2721 documents
Contemporary Outcomes for the Curative Treatment of Colorectal Cancer Pulmonary Metastases.
2023
Purpose: Treatment of pulmonary metastases (PM) from colorectal cancer (CRC) is the standard of care by several guidelines from Europe and the USA, but the validity of this strategy has been recently questioned, and the available evidence supporting this strategy is weak. We report the outcomes of a curative intent strategy in a very recent and homogenous series of patients. Methods: We did a retrospective review of all curative intent surgical or ablative treatment of PM from CRC performed consecutively in 3 French institutions from January 2015 to December 2019. Demographics, clinicopathological, and molecular characteristics were evaluated. Cox regression models were used to identify pro…
Analysis of the Thymidylate Synthase Gene Structure in Colorectal Cancer Patients and lts Possible Relation with the S-Fluorouracil Drug Response
2010
Thymidylate synthase (TS) catalyzes methylation of dUMP to dTMP and it is the target for the 5-Fluorouracil (5-FU) activity*. Barbour et al. showed that variant structural forms of TS in tumour cell lines confer resistance to fluoropyrimidines. We planned to perform the whole TS gene structure by means of sequencing techniques in human colorectal cancer (CRC) san-rples to try to identify the presence of any possible TS variant form that could be responsible of fluoropyrimidines drug resistance and of the worse prognosis. We performed the TS-DNA gene sequence in 68 CRC from patients of A, B, and C Dukes' stages and different histological grade, but we did not find any mutation in the TS-DNA …
Could a variant structural form of thymidylate synthase gene of metastatic colorectal cancer patients be related with the poor response to 5 Fu treat…
2008
Background: Thymidylate synthase (TS) catalyzes methylation of dUMP to dTMP and is the target of 5-fluorouracil (5-Fu). TS levels vary considerably among tumors and the response to 5-FU is influenced by the intratumoral activity of the enzyme, with high levels generally being associated with a poor response. Response to 5-FU also depends on TS structure and some researchers showed that variant structural forms of TS in tumour cell lines confer resistance to fluoropyrimidines so the aim our study is to analyze the whole coding regions of the TS gene to evaluate a possible mechanism of 5 Fu resistance. Materials and Methods: We performed the TS-DNA gene sequence in 68 colorectal cancer (CRC) …
Qualitative and quantitative evaluation of solitary thyroid nodules with contrast-enhanced ultrasound: initial results
2005
To assess the feasibility of contrast-enhanced ultrasound (CEUS) of the thyroid gland and to evaluate the potential of this method for characterising solitary thyroid nodules.18 patients affected by solitary thyroid nodules (size range: 0.6 to 3.6 cm; mean: 1.8 cm) confirmed by surgery (nine papillary carcinomas, four follicular carcinomas, three hyperplasias, one follicular adenoma and one Plummer’s adenoma) underwent pulse inversion US at low M.I. (0.06 to 0.08) after i.v. injection of a 2.4-mL bolus of SonoVue. Baseline echogenicity and the dynamic enhancement pattern of each nodule, in comparison with adjacent thyroid parenchyma, were assessed. Signal intensity values on grey-scale imag…
A study of electron transfer in Ru(dcbpy)2(NCS)2 sensitized nanocrystalline TiO2 and SnO2 films induced by red-wing excitation.
2008
Excited state dynamics and electron transfer from the Ru(dcbpy)2(NCS)2 (RuN3) sensitizer to semiconductor nanoparticles were studied using time-resolved femtosecond absorption spectroscopy. We found that excitation of the red wing of the absorption spectrum of the sensitizer populates the (3)MLCT state directly, both in solution and attached on semiconductor nanoparticle films. Electron injection is slowed down and becomes gradually less efficient as excitation moves towards red from the absorption maximum at 535 nm. At 675 nm the injection is non-exponential and characterized by 5, 30 and 180 ps time constants. The non-exponential electron injection observed is assigned to injection from a…
Enzymatic, physicochemical, nutritional and phytochemical profile changes of apple (Golden Delicious L.) juice under supercritical carbon dioxide and…
2018
The impact of supercritical carbon dioxide (SCCD) (10-60 MPa/45 °C/30 min) and subsequent 10 weeks storage at 4 °C on polyphenol oxidase (PPO), peroxidase (POD) activities, phenolic profile, vitamin C, sugars, physicochemical properties of cloudy apple juices was investigated. No significant changes in sugars and total polyphenols were observed, whereas significant degradation (≈28%) of vitamin C and individual polyphenols (≈18%) was noted after SCCD treatment. After 4 weeks storage only 34% of vitamin C was retained and no vitamin C was detected after this time. Ten weeks of storage caused hydrolysis of sucrose in 15%, whereas degradation of individual polyphenols ranged from 43 to 50% dep…
A thin layer-based amperometric enzyme immunoassay for the rapid and sensitive diagnosis of respiratory syncytial virus infections
2012
Abstract A simple electrochemical sandwich immunoassay involving a polystyrene microarray slide coated with monoclonal capture antibodies and carbon screen-printed sensors (SPS) was designed for the rapid diagnosis of respiratory syncytial virus (RSV). The detection of the antibody-antigen complex formation relied on the use of a horseradish peroxidase conjugate. Its chronoamperometric measurement detection was performed by confining a droplet of H 2 O 2 /3,3',5,5'-tetramethylbenzidine enzyme substrate/mediator solution within a thin layer between one spot of the microarray and the surface of one screen-printed electrochemical cell. The accumulation of the enzyme product in the thin film of…
Color memory matching: Time effect and other factors
1998
The methods of simultaneous and successive, or memory, color matching have been compared for 10 color reference samples distributed in two groups each performed by 50 observers (25 men and 25 women). Our results, obtained with a total of two hundred Munsell color chips arrayed on ten gray cardboard panels, indicate that: (a) while by simultaneous matching the mean color differences obtained are, in most cases, lower than 1 CIELAB unit, those obtained by memory are generally higher; (b) the worst remembered colors are yellow, light green, blue, and pink, and the best remembered color is orange; (c) the influence of the delay time (15 s, 15 min, and 24 h) is significant for the remembered mea…
Color memory in protanomals and deuteranomals: Matching time effect
2003
In a companion paper Perez-Carpinell et al., Color Res Appl 2001;26:158–170, for a set of seven color references, we compared the methods of simultaneous and memory color matching by 15 protanomals and 21 deuteranomals, looking for differences between them and a group of 25 normal trichromat observers investigated previously Perez-Carpinell et al., Color Res Appl 1998;23:234–247. In our current article, matching times of the same anomalous trichromat groups, and with the same reference tests, to select from among the comparison chips the one that most resembled one of the seven reference tests, have been measured under simultaneous and successive color matching procedures. From comparison b…
Photocatalytic degradation of acid blue 80 in aqueous solutions containing TiO2 suspensions.
2001
The photocatalytic degradation of the anthraquinonic dye Acid Blue 80 in aqueous solutions containing TiO2 dispersions has been investigated. The process has been monitored by following either the disappearance of the dye (via HPLC) and the formation of its end-products (via IC, GC, and TOC analysis). Although a relatively fast decolorization of the solutions has been observed, the mineralization is slower, and the presence of residual organic compounds was evidenced even after long term irradiation, confirming the relevant stability of anthraquinone derivatives. The identification of various unstable intermedi ates formed after low irradiation times was performed by HPLC-MS, allowing us to…