Search results for "Color"
showing 10 items of 2721 documents
Characterization of a digital camera as an absolute tristimulus colorimeter
2003
An algorithm is proposed for the spectral and colorimetric characterization of digital still cameras (DSC) which allows them to be used as tele-colorimeters with CIE-XYZ color output, in cd/m2. The spectral characterization consists in the calculation of the color-matching functions from the previously measured spectral sensitivities. The colorimetric characterization consists in trans- forming the raw RGB digital data into absolute tristimulus values CIE-XYZ (in cd/m2) under variable and unknown spectroradiometric conditions. Thus, in the first stage, a gray balance was applied over the raw RGB digital data to convert them into RGB relative colorimetric values. In the second stage, an algo…
Weakly interacting dark matter in walking technicolor theories
2010
Several lines of evidence support the existence of the dark matter in the Universe. In the light of the present observations the particle dark matter, and in particular the WIMP scenario is a very promising alternative to solve the dark matter problem. In this context recent minimal walking techicolor model motivated dark matter models have been studied. The minimal walking techinicolor and the minimal extension of it, which can successfully provide a dynamical origin for the electroweak symmetry breaking as well as the unification of the standard model coupling constants, gives rise to natural dark matter candidates such as fourth family heavy neutrinos and SU(2) adjoint matter. A general …
Estándares de Calidad de la cirugía de las metástasis hepáticas del cáncer de colon
2018
Las lesiones sólidas malignas más frecuentes en el hígado son las metástasis hepáticas (MH), de las cuales, aproximadamente el 40% son de tumores de origen colorrectal. El tratamiento curativo de las metástasis hepáticas de origen colorrectal (MHCCR) sigue siendo la resección hepática (RH), siempre que la cirugía logre una resección completa y se preserve suficiente parénquima hepático sano para mantener la función hepática mientras se produce la regeneración del órgano. A pesar del importante impacto que supone esta patología, actualmente no se dispone de una imagen global acerca de los resultados de esta cirugía. Para poder evaluar de forma objetiva la calidad en los resultados de la ciru…
A perspective analysis: microRNAs, glucose metabolism, and drug resistance in colon cancer stem cells
2021
Metabolism sustains the stemness of Cancer Stem Cells (CSCs), affecting, in turn, tumor heterogeneity, metastatic potential, and therapy resistance. Therefore, it is appealing to target CSCs metabolism as a new therapeutic approach. Consequently, we paid considerable attention to the anti-apoptotic microRNA miR-483-3p, that we reported being regulated by glucose metabolism in liver cancer cells. We investigated the therapeutic potential of targeting miR-483-3p by using the anti-glucose metabolism 2-deoxyglucose (2-DG) molecule in tumor Xenograft mouse model originating from two different Colon-Cancer Stem Cell lines (CCSC lines). We show that 2-DG treatment does not affect CCSCs during tumo…
Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype
2021
ABSTRACT Colon cancer progression is among the risks that increase with obesity. We have recently unveiled the molecular mechanism by which adipose tissue-released molecules, HGF and IL-6, make colorectal cancer (CRC) cells acquiring mesenchymal traits. Targeting of adipose-derived factors abrogate the metastatic potential of CRC stem cells (CR-CSCs) in obese patients.
Dual Inhibition of Myc Transcription and PI3K Activity Effectively Targets Colorectal Cancer Stem Cells
2022
Despite advances in the curative approach, the survival rate of advanced colorectal cancer (CRC) patients is still poor, which is likely due to the emergence of cancer cell clones resistant to the available therapeutic options. We have already shown that CD44v6-positive CRC stem cells (CR-CSCs) are refractory toward standard anti-tumor therapeutic agents due to the activation of the PI3K pathway together with high HER2 expression levels. Tumor microenvironmental cytokines confer resistance to CR-CSCs against HER2/PI3K targeting by enhancing activation of the MAPK pathway. Here, we show that the CSC compartment, spared by BRAF inhibitor-based targeted therapy, is associated with increased ex…
Colorectal Cancer Stem Cells and Cell Death
2011
Nowadays it is reported that, similarly to other solid tumors, colorectal cancer is sustained by a rare subset of cancer stem-like cells (CSCs), which survive conventional anticancer treatments, hanks to efficient mechanisms allowing escape from apoptosis, triggering tumor recurrence. To improve patient outcomes, conventional anticancer therapies have to be replaced with specific approaches targeting CSCs. In this review we provide strong support that BMP4 is an innovative therapeutic approach to prevent colon cancer growth increasing differentiation markers expression and apoptosis. Recent data suggest that in colorectal CSCs, protection from apoptosis is achieved by interleukin-4 (IL-4) a…
Dissecting the Mechanism of Action of Spiperone—A Candidate for Drug Repurposing for Colorectal Cancer
2022
Approximately 50% of colorectal cancer (CRC) patients still die from recurrence and metastatic disease, highlighting the need for novel therapeutic strategies. Drug repurposing is attracting increasing attention because, compared to traditional de novo drug discovery processes, it may reduce drug development periods and costs. Epidemiological and preclinical evidence support the antitumor activity of antipsychotic drugs. Herein, we dissect the mechanism of action of the typical antipsychotic spiperone in CRC. Spiperone can reduce the clonogenic potential of stem-like CRC cells (CRC-SCs) and induce cell cycle arrest and apoptosis, in both differentiated and CRC-SCs, at clinically relevant co…
Color Conversion Light-Emitting Diodes Based on Carbon Dots: A Review
2022
This paper reviews the state-of-the-art technologies, characterizations, materials (precursors and encapsulants), and challenges concerning multicolor and white light-emitting diodes (LEDs) based on carbon dots (CDs) as color converters. Herein, CDs are exploited to achieve emission in LEDs at wavelengths longer than the pump wavelength. White LEDs are typically obtained by pumping broad band visible-emitting CDs by an UV LED, or yellow–green-emitting CDs by a blue LED. The most important methods used to produce CDs, top-down and bottom-up, are described in detail, together with the process that allows one to embed the synthetized CDs on the surface of the pumping LEDs. Experimental results…
Expresión de microRNAs en la zonas de transición epitelio mesenquimal en el carcinoma colorectal como factor inmunomodulador y pronóstico. Estudio cl…
2018
El subgrupo mesenquimal (CMS4) de la clasificación molecular de consenso de cáncer colorectal es el tipo más agresivo y de peor pronóstico, y se caracteriza por la sobre expresión de genes implicados en el mecanismo de transición epitelio mesenquimal (TEM). La desdiferenciación tumoral focal (DTF) es el reflejo histológico del proceso de TEM. En base a estos conocimientos nos planteamos explorar la influencia de la DTF en la expresión de genes y microRNAs implicados en el proceso de TEM y evaluar su utilidad como factores predictivos de supervivencia. Analizamos de forma retrospectiva el grado de DTF en una serie de 125 especímenes de colectomía en todos los estadios clínicos. Evaluamos la …