Search results for "Colore"

Comparison of a 48-Hour Infusion of 5-Fluorouracil without Folinic Acid with 24-Hour Folinic Acid/5-Fluorouracil in Patients with Metastatic Colorect…

2003

<i>Background:</i> Out of various high-dose 5-fluorouracil (5-FU) regimens given with or without folinic acid (FA), the optimal 5-FU schedule has still to be defined as treatment for metastatic colorectal cancer (CRC). Consequently, we compared toxicity, response and survival following two FA/5-FU regimens in 55 CRC patients refractory to bolus FA/5-FU. <i>Methods:</i> Twenty-eight patients (group A) received 5-FU (60 mg/kg body weight) for 48 h, and 27 (group B) received 2-hour infusions of FA (500 mg/m<sup>2</sup>) and 24-hour infusions of 5-FU (2,600 mg/m<sup>2</sup>) until disease progression. <i>Results:</i> Both groups were a…

Shikonin reduces the tumour formation and IL-17 in a model of colorectal cancer associated to chronic colitis in C57BL/6 mice

2016

The Crosstalk Between Signaling Pathways and Cancer Metabolism in Colorectal Cancer.

2021

Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide. Metabolic reprogramming represents an important cancer hallmark in CRC. Reprogramming core metabolic pathways in cancer cells, such as glycolysis, glutaminolysis, oxidative phosphorylation, and lipid metabolism, is essential to increase energy production and biosynthesis of precursors required to support tumor initiation and progression. Accumulating evidence demonstrates that activation of oncogenes and loss of tumor suppressor genes regulate metabolic reprogramming through the downstream signaling pathways. Protein kinases, such as AKT and c-MYC, are the integral components that facilitate the crosstalk bet…

Hsp60 and Hsp10 as antitumour molecular agents

2007

The molecular chaperones Hsp60 and Hsp10 are, according to recent reports, involved in cancer development and progression. We, for instance, have found that their expression varies with distinctive patterns in different malignancies: they are overexpressed in colorectal, exocervical and prostate carcinogenesis, and colorectal cancer progression, but they are downregulated during bronchial carcinogenesis. There is also evidence showing that Hsp60 and Hsp10 can be used as therapeutic agents, for example in rheumatoid arthritis. In view of these findings we want now to call attention to the potential of Hsp60 and Hsp10 in cancer therapy.

A Tensorial Formalism Adapted to the Rovibronic Couplings in the Colored Hexafluorides: Application to the nu(5)(F(2g)) and nu(3)(F(1u)) Modes.

2000

A tensorial formalism adapted to the case of transition-metal hexafluorides in a degenerate electronic state has been developed on the basis of preceding works about spherical-top molecules in a nondegenerate electronic state. We have introduced electronic operators constructed using group theory features and some physical considerations. Vibronic couplings (Jahn-Teller effect, etc.) have been reviewed for the triply degenerate vibrational modes nu(5)(F(2g)) and nu(3)(F(1u)) leading to the identification of the main vibronic parameters. For the first time, an effective rovibronic Hamiltonian as well as the effective transition moment operators (dipole moment and polarizability) for rovibron…

EFFECTS OF COLORED NOISE IN SHORT OVERDAMPED JOSEPHSON JUNCTION

2008

We investigate the transient dynamics of a short overdamped Josephson junction with a periodic driving signal in the presence of colored noise. We analyze noise induced henomena, specifically resonant activation and noise enhanced stability. We find that the positions both of the minimum of RA and maximum of NES depend on the value of the noise correlation time tau_c. Moreover, in the range where RA is observed, we find a non-monotonic behavior of the mean switching time as a function of the correlation time tau_c.

Noise induced effects in overdamped Josephson junction in the presence of colored noise

2007

We analyze the role of the correlated fluctuations, with a correlation time τc, in the dynamics of an overdamped Josephson junction in the presence of a periodic driving signal.

LHC bounds on colored scalars

2019

We analyze the constraints on coloured scalar bosons imposed by the current LHC data at $\sqrt{s}=13$ TeV. Specifically, we consider an additional electroweak doublet of colour-octet scalars, satisfying the principle of Minimal Flavour Violation in order to fulfill the stringent experimental limits on flavour-changing neutral currents. We demonstrate that coloured scalars with masses below 800 GeV are already excluded, provided they are not fermiophobic.

Terza Missione del DARCH

2017

La presenza del Piano del Colore nell’agenda delle attività del Comune di Favignana è segno importante di una volontà politica che intende orientare in termini qualitativi lo sviluppo di un territorio particolarmente sensibile. A tal fine, il Comune ha coinvolto la sezione di Trapani dell'INBAR che si è avvalsa della consulenza scientifica del Dipartimento di Architettura dell'Università degli Studi di Palermo. L’impegno del Dipartimento di Architettura, che sviluppa come Terza Missione l’impiego della ricerca scientifica per contribuire allo sviluppo sociale, culturale ed economico della società, è rivolto ad affrontare il Piano del Colore come strumento urbanistico per salvaguardare i val…

Colorectal Cancer Stem Cells: From the Crypt to the Clinic

2014

Since their first discovery, investigations of colorectal cancer stem cells (CSCs) have revealed some unexpected properties, including a high degree of heterogeneity and plasticity. By exploiting a combination of genetic, epigenetic, and microenvironmental factors, colorectal CSCs metastasize, resist chemotherapy, and continually adapt to a changing microenvironment, representing a formidable challenge to cancer eradication. Here, we review the current understanding of colorectal CSCs, including their origin, relationship to stem cells of the intestine, phenotypic characterization, and underlying regulatory mechanisms. We also discuss limitations to current preclinical models of colorectal …