6533b7d2fe1ef96bd125e8db
RESEARCH PRODUCT
Hsp60 and Hsp10 as antitumour molecular agents
Alberto J. L. MacarioFrancesco CappelloAnna M. CzarneckaGiampiero La RoccaGiovanni ZummoAntonino Di Stefanosubject
PharmacologyOncologyCancer Researchmedicine.medical_specialtyanimal structuresbusiness.industryColorectal cancermedicine.medical_treatmentfungiCancerImmunotherapyMouse model of colorectal and intestinal cancermedicine.diseasemedicine.disease_causeOncologyRheumatoid arthritisInternal medicineMolecular MedicineMedicineHSP60Cancer developmentbusinessCarcinogenesisdescription
The molecular chaperones Hsp60 and Hsp10 are, according to recent reports, involved in cancer development and progression. We, for instance, have found that their expression varies with distinctive patterns in different malignancies: they are overexpressed in colorectal, exocervical and prostate carcinogenesis, and colorectal cancer progression, but they are downregulated during bronchial carcinogenesis. There is also evidence showing that Hsp60 and Hsp10 can be used as therapeutic agents, for example in rheumatoid arthritis. In view of these findings we want now to call attention to the potential of Hsp60 and Hsp10 in cancer therapy.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-04-10 | Cancer Biology & Therapy |