Search results for "Coma"
showing 10 items of 1084 documents
Periodicidad y movilidad del comercio: Mercados y ferias valencianos a mediados del siglo XIX
1990
El objetivo de este artículo es analizar la localización y características de los mercados y ferias valencianos de mediados del siglo XIX en función de la teoría económica que explica la periodicidad y movilidad del comercio y la secuencia evolutiva de formación de un comercio estable. El estudio realizado demuestra que existe una estrecha relación entre la organización comercial comarcal y la densidad de población, la estructura de asentamientos y la accesibilidad a las principales corrientes comerciales interregionales, Por otra parte, la localización de las ferias está en función de la existencia de límites entre regiones económicas complementarias, cambios de pendiente y puntos de ruptu…
Entes territoriales de escala comarcal en la Administración local española
2021
El mapa autonómico español creado a partir de 1978 se superpuso al esquema territorial que ya existía, formado por provincias y municipios, y así ha tenido que convivir con un mapa anterior obsoleto e ineficiente. La mayoría de los municipios son demasiado pequeños para proveerse de servicios, y esta insuficiencia en la prestación de los mismos no ayuda a frenar el despoblamiento rural. En algunas comunidades autónomas, se han intentado crear entes intermedios entre la provincia y el municipio ¿generalmente, comarcas¿ para tratar de corregir los desequilibrios territoriales. Solo algunas de estas comunidades han llevado finalmente a cabo un proceso de transferencia de competencias a estos n…
Patogenesi Del Sarcoma Di Kaposi
2005
Il sarcoma uterino: nostra esperienza
2006
Gli Autori riferiscono su 7 casi di sarcomi uterini, di cui 3 casi di leiomiosarcoma, 2 casi di sarcoma misto, 1 caso di sarcoma stromale endometriale ed evidenziano che la diagnosi clinico-strumentale prechirurgica di sarcoma uterino è molto difficile. La terapia chirurgica rimane il trattamento principale. L'efficacia della terapia adiuvante chemioterapica deve essere ancora verificata. I dati riportati, in accordo con quelli della letteratura, confermano l'atteggiamento aggressivo del sarcoma uterino con alta incidenza delle recidive
The development of benzimidazoles as selective rho kinase inhibitors
2010
Rho Kinase (ROCK) is a serine/threonine kinase whose inhibition could prove beneficial in numerous therapeutic areas. We have developed a promising class of ATP-competitive inhibitors based upon a benzimidazole scaffold, which show excellent potency toward ROCK (IC(50)<10nM). This report details the optimization of selectivity for ROCK over other related kinases such as Protein kinase A (PKA).
IL PARTENOLIDE INDUCE MORTE CELLULARE CASPASI-INDIPENDENTE IN CELLULE DI OSTEOSARCOMA UMANO MG63
2011
Role of sparc and MIR-29B1 in molecular effects induced by win in osteosarcoma MG63 cells
2014
SPARC (Secreted protein acidic and rich in cysteine) is considered as a prototype of matricellular protein due to its structure and the function that it displays in regulating cell/extracellular microenvironment interactions during development and in response to injury. Earlier studies underlined pleiotropic effects of intracellular SPARC on cancer growth and, in some cancer cell lines, identified it as a tumor suppressor protein. Objective This study aimed to evaluate the role of SPARC and its related miRNA in the molecular effects induced by the cannabinoid WIN in osteosarcoma MG63 cells. In these cells WIN is not able to induce cell death but sensitizes cells to TRAIL-mediated apoptotic …
Parthenolide induces caspase-independent cell death in osteosarcoma, melanoma and breast cancer cells through the induction of oxidative stress.
2012
Parthenolide, a sesquiterpene lactone found in European feverfew, is used in traditional medicine for its anti-inflammatory activity. In addition, parthenolide has been considered as a novel and effective anti-tumor agent because it induces cytotoxic effects in several tumor cell lines. Our studies demonstrated that parthenolide exerted strong cytotoxic effects in osteosarcoma MG63 and melanoma SK-Mel28 cells in culture. Staining with Hoechst 33342 revealed in most cells after brief periods of treatments (3-5h) chromatin condensation and fragmentation, while only few cells were PI-positive. Prolonging the treatment (5-14h) PI-positive cells strongly augmented, denouncing the increase of nec…
WIN modulates osteosarcoma MG63 cell migration by inhibiting MMPs activity and adjusting intra- and extra-cellular SPARC differential expression
2014
Invasion of cancer cells into surrounding tissue is an initial step in tumor metastasis. This event, which requires migration of cancer cells and attachment to extracellular matrix (ECM), is regulated by elements of the local microenvironment, including ECM architecture. After having demonstrated the ability of the synthetic cannabinoid WIN55,512 to induce osteosarcoma MG63 cell death (1), we studied the effects of WIN on MG63 cell migration. Wound healing assay was performed to measure the ability of cells to migrate and fill the gap obtained by physical disruption of cell monolayer (2). We observed a significant delay in wound closure in 5 M WIN treated cells compared to untreated cells …
Influence of the effectiveness factors in assessing the shear capacity of RC beams strengthened with FRP
2021
Shear failure of RC beams strengthened with composite textiles is often affected by the different failure modes characterizing the FRP reinforcement. The most relevant analytical models for evaluating the shear capacity of RC beams strengthened with FRP take into account these failure modes by introducing an effectiveness factor “R”, which reduces the ultimate FRP tensile stress. Moreover, the interaction between stirrups and FRP reinforcement leads to a reduced efficiency of the transverse steel reinforcement due to the brittle failure of composite textile which hinders the yielding of all the stirrups involved by critical crack. In this regard, some analytical models introduce an effectiv…