Search results for "Coma"
showing 10 items of 1084 documents
Factores asociados a las conductas de riesgo para la transmisión del VIH en toxicómanos
2000
Diferentes líneas de estudio, enlazadas en un nexo común, han demostrado la existencia de múltiples factores relacionados con las conductas de riesgo para la transmisión del VlH. Mediante una revisión bibliográfica se pretende ofrecer una visión holística sobre los principales factores bio-psico-sociales más estrechamente vinculados con la aparición y el mantenimiento de estas prácticas de riesgo. Algunos de estos factores escaparía de la posibilidad de intervención por parte de los recursos asistenciales. Sin embargo existen otros factores, esencialmente de tipo psicológico (momento de la notificación, realización del test serológico para el VIH, sentimiento de invulnerabilidad, "distorsió…
Absence of mutation at the GAP-related domain of the neurofibromatosis type 1 gene in sporadic neurofibrosarcomas and other bone and soft tissue sarc…
1995
The NF1 gene encodes neurofibromin, a GTPase-activating protein containing a GAP-related domain (NF1-GRD) that is capable of downregulating ras by stimulating ras intrinsic GTPase activity. We tested 44 sarcomas, nine of which corresponded to sporadic neurofibrosarcomas, for mutations at the NF1-GRD by the polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) technique, finding no mutation in every sample tested. We suggest that inactivation of the NF1-GRD by gene mutation seems not to be an important event in the tumorigenesis of sarcomas.
Bleomycin: Action on growth of oncogenic RNA viruses and on cell transformation
1975
Bleomycin (BLM) inhibits cell proliferation of noninfected chick embryo fibroblasts by blocking their DNA synthesis selectively. Chick embryo fibroblasts have beentransformed by Schmidt-Ruppin D strain of Rous Sarcoma Virus. Transformation has been determined by a focus assay. Foci formation is strongly reduced by BLM. Virus replication is inhibited by BLM in growing and confluent monolayer cells. This result might be explained by the observation that this drug reduces proliferation of growing and of confluent monolayer cells very sensitively. During the first 24 hours after infection the BLM inhibitory effect is more pronounced than in the case of BLM-application during the period 24--48 h…
WRN protects against topo I but not topo II inhibitors by preventing DNA break formation
2008
The Werner syndrome helicase/3′-exonuclease (WRN) is a major component of the DNA repair and replication machinery. To analyze whether WRN is involved in the repair of topoisomerase-induced DNA damage we utilized U2-OS cells, in which WRN is stably down-regulated (wrn-kd), and the corresponding wild-type cells (wrn-wt). We show that cells not expressing WRN are hypersensitive to the toxic effect of the topoisomerase I inhibitor topotecan, but not to the topoisomerase II inhibitor etoposide. This was shown by mass survival assays, colony formation and induction of apoptosis. Upon topotecan treatment WRN deficient cells showed enhanced DNA replication inhibition and S-phase arrest, whereas af…
Beneficial effects of saffron (
2020
Saffron (Crocus sativus L.) has been traditionally used in food preparation and as a medicinal plant. It currently has numerous therapeutic properties attributed to it, such as protection against ischemia, as well as anticonvulsant, antidepressant, anxiolytic, hypolipidemic, anti-atherogenic, anti-hypertensive, antidiabetic, and anti-cancer properties. In addition, saffron has remarkable beneficial properties, such as anti-apoptotic, anti-inflammatory and antioxidant activities, due to its main metabolites, among which crocin and crocetin stand out. Furthermore, increasing evidence underwrites the possible neuroprotective role of the main bioactive saffron constituents in neurodegenerative …
The effect of peracetic acid on microbial community, water quality, nitrification and rainbow trout (Oncorhynchus mykiss) performance in recirculatin…
2020
Microbial biofilters control water quality and enable the overall function of recirculation aquaculture systems (RAS). Changes in environmental conditions can affect the abundance and interactions of the diverse microbial populations of the biofilter, affecting nitrification of harmful ammonium and thus fish health. Here, we examined the effect of different application frequencies (0, 1, 2 and 4 times per week) of a common disinfectant, peracetic acid (PAA, applied 1.1 mg l−1 twice per day), on biofilter microbial communities, focusing especially on nitrifying microbial groups and using a high throughput sequencing of 16S rRNA gene and quantitative PCR (qPCR). In addition, we measured biofi…
CARCINOSARCOMA ARISING IN A DERMOID CYST OF OVARY: A CASE REPORT
2005
BACKGROUND: Transformation of a cystic benign teratoma of the ovary into a "carcinosarcoma" has very rarely been reported and its histogenetic origin is still debated. CASE PRESENTATION: A case of carcinosarcoma arising from a dermoid cyst is reported. The tumor showed cystic areas delimited by normal squamous epithelium, with transitional areas through dysplastic epithelium to "in situ" and infiltrating squamous cell carcinoma (SCC). The sarcomatous component showed compact tissue composed of round cells concentrically arranged around small vessels, spindle, and pleomorphic cells with a high nuclear-cytoplasmic ratio. Positive staining for vimentin, alpha smooth muscle actin and CD10, as w…
Rhabdomyosarcoma of the Oral Tissues: two new cases and literature review
2006
Rhabdomyosarcoma (RMS) is a malignant soft tissue neoplasm consisting of cells derived from the primitive mesenchyme that exhibit a profound tendency to myogenesis. About 35% of RMS arises in the head and neck, being classified as parameningeal and non-orbital non-parameningeal forms. Parameningeal tumors carry the worst prognosis. The use of contemporary, multi-agent chemotherapy, radiotherapy, and surgery has made treatment of the disseminated disease possible, and has significantly improved overall survival from 25% in 1970 to 70% in 1991. Here, we present the management of two cases of orofacial RMS in adolescents: an 18-year-old, white female that had a 9-month history of a nodule in t…
Omicidi mirati a mezzo drone: brevi riflessioni a margine del caso "Lo Porto" tra diritto penale e diritto internazionale
2018
Quale diritto penale in ipotesi di "vittime collaterali" di drone strike? La sempre maggiore rilevanza che il fenomeno degli omicidi mirati a mezzo drone assume nel contesto internazionale pone la necessità di interrogarsi su come, nell'ordinamento interno, le categorie classiche del diritto penale debbano operare rispetto a fattispecie "peculiari", caratterizzate da una distanza fisica e psichica dal target e dall’esistenza di una “catena di comando” coinvolta, a più livelli, nella singola operazione di omicidio mirato. Si cercherà pertanto di capire, partendo dal caso dell'omicidio di un cittadino italiano per mezzo di droni statunitensi in Pakistan, ma fornendo un contributo di portata p…
Nuove linee guida americane 2013 ACC/AHA sul trattamento del colesterolo plasmatico per ridurre il rischio cardiovascolare aterosclerotico: confronto…
2014
No abstract available