Search results for "Comment"

Molecular pathway activation – New type of biomarkers for tumor morphology and personalized selection of target drugs

2018

Anticancer target drugs (ATDs) specifically bind and inhibit molecular targets that play important roles in cancer development and progression, being deeply implicated in intracellular signaling pathways. To date, hundreds of different ATDs were approved for clinical use in the different countries. Compared to previous chemotherapy treatments, ATDs often demonstrate reduced side effects and increased efficiency, but also have higher costs. However, the efficiency of ATDs for the advanced stage tumors is still insufficient. Different ATDs have different mechanisms of action and are effective in different cohorts of patients. Personalized approaches are therefore needed to select the best ATD…

COSTITUZIONE RAGIONATA - IV EDIZIONE

2017

COMMENTARIO ALLA COSTITUZIONE ITALIANA

Le Troiane. Saggio introduttivo, nuova traduzione e note

2021

Una donna entra in scena, schiacciata dagli innumerevoli lutti e dal crollo di un regno, che il suo corpo piegato s’incarica di rappresentare. È Ecuba, ultima sovrana del grande impero troiano. La lunga notte di Troia si è appena conclusa; l’alba di un nuovo giorno, offuscato dal fumo degli incendi, segna l’avvio del dramma. La guerra è finita, i Greci hanno vinto, ma i pesanti rovesci di fortuna imposti ai Troiani non cessano di imporre ulteriori sofferenze. La principessa Polissena e il piccolo Astianatte, il figlio prediletto di Ettore, dovranno morire; le prigioniere troiane, protagoniste indiscusse di canti dolenti, partiranno presto alla volta della Grecia, schiave di odiosi padroni. …

How Do Explicitly Expressed Emotions Influence Interpersonal Communication and Information Dissemination? : A Field Study of Emoji's Effects on Comme…

2016

Commentary on the MID3 Good Practices Paper

2017

Contains fulltext : 178217.pdf (Publisher’s version ) (Open Access) During the last 10 years the European Medicines Agency (EMA) organized a number of workshops on modeling and simulation, working towards greater integration of modeling and simulation (M&S) in the development and regulatory assessment of medicines. In the 2011 EMA - European Federation of Pharmaceutical Industries and Associations (EFPIA) Workshop on Modelling and Simulation, European regulators agreed to the necessity to build expertise to be able to review M&S data provided by companies in their dossier. This led to the establishment of the EMA Modelling and Simulation Working Group (MSWG). Also, there was agreement reach…

Early cave art and ancient DNA record the origin of European bison

2016

The two living species of bison (European and American) are among the few terrestrial megafauna to have survived the late Pleistocene extinctions. Despite the extensive bovid fossil record in Eurasia, the evolutionary history of the European bison (or wisent, Bison bonasus) before the Holocene (<11.7 thousand years ago (kya)) remains a mystery. We use complete ancient mitochondrial genomes and genome-wide nuclear DNA surveys to reveal that the wisent is the product of hybridization between the extinct steppe bison (Bison priscus) and ancestors of modern cattle (aurochs, Bos primigenius) before 120 kya, and contains up to 10% aurochs genomic ancestry. Although undetected within the fossil re…

Anthropometric Indicators as a Tool for Diagnosis of Obesity and Other Health Risk Factors: A Literature Review

2021

[EN] Obesity is characterized by the accumulation of an excessive amount of fat mass (FM) in the adipose tissue, subcutaneous, or inside certain organs. The risk does not lie so much in the amount of fat accumulated as in its distribution. Abdominal obesity (central or visceral) is an important risk factor for cardiovascular diseases, diabetes, and cancer, having an important role in the so-called metabolic syndrome. Therefore, it is necessary to prevent, detect, and appropriately treat obesity. The diagnosis is based on anthropometric indices that have been associated with adiposity and its distribution. Indices themselves, or a combination of some of them, conform to a big picture with di…

Gambling disorder in adolescents: what do we know about this social problem and its consequences?

2018

Abstract Gambling disorder (GD) is a psychiatric condition and it is characterized by a maladaptive pattern of gambling behavior that persists despite negative consequences in major areas of life functioning. In Italy, CNR (National Research Council) underlined how over 17 million, 42.8% of the population aged 15–64 have a gambling behavior. Among them, there are over one million students, aged 15–19, equal to 44.2% of Italian students; the number of minors in Italy with GD in 2017 was 580,000, equal to 33.6%. Various psychosocial treatment models have been adapted for GD; on the other hand no drug has received regulatory approval in any jurisdiction as a specific psychopharmacological trea…

Social Collaborative Viewpoint Regression with Explainable Recommendations

2017

A recommendation is called explainable if it not only predicts a numerical rating for an item, but also generates explanations for users' preferences. Most existing methods for explainable recommendation apply topic models to analyze user reviews to provide descriptions along with the recommendations they produce. So far, such methods have neglected user opinions and influences from social relations as a source of information for recommendations, even though these are known to improve the rating prediction. In this paper, we propose a latent variable model, called social collaborative viewpoint regression (sCVR), for predicting item ratings based on user opinions and social relations. To th…

Mice are not Men: ADAM30 Findings Emphasize a Broader Look Towards Murine Alzheimer's Disease Models

2016

Due to the growing population of people at advanced age, the number of patients affected by Alzheimer's disease (AD) is increasing tremendously. In 2015 about 46.8 million people suffered from AD worldwide which is estimated to increase to 131.5 million by 2050. Brains of AD patients all show a common histopathology; they are marked by an atrophy and degeneration that is caused by a severe loss of neurons and synapses (Braak and Del Tredici, 2012). Moreover, so-called extracellular senile plaques that consist of predominantly amyloid β (Aβ) peptides can be detected in the grey matter where they surround neurons. Since generation of Aβ peptides is hypothesized to play a major role in AD path…