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RESEARCH PRODUCT
May the force be with you: Transfer of healthy mitochondria from stem cells to stroke cells
Trenton LippertCesar V. BorlonganHung NguyenYuji KanekoKaya XuEleonora RussoEleonora NapoliPaul R. SanbergJea Young LeeJulian P. Tuazonsubject
Cardiorespiratory Medicine and HaematologyMitochondrionRegenerative medicineRats Sprague-Dawley0302 clinical medicineStem Cell Research - Nonembryonic - Humanenergy metabolismStrokeStem CellsBrainCerebral ischemiaMitochondriaStrokeNeurologycellular bioenergeticStem Cell Research - Nonembryonic - Non-HumanStem cellmedicine.symptomCardiology and Cardiovascular Medicine1.1 Normal biological development and functioningClinical SciencesEnergy metabolismregenerative medicineInflammation03 medical and health sciencesUnderpinning researchmedicineAnimalsHumansNeurology & NeurosurgeryAnimalbusiness.industryMechanism (biology)NeurosciencesStem Cell Researchmedicine.diseaseRatsBrain DisordersTransplantationDisease Models AnimalinflammationDisease ModelsCommentarycellular bioenergeticsSprague-DawleyNeurology (clinical)businessNeuroscience030217 neurology & neurosurgerytransplantationdescription
Stroke is a major cause of death and disability in the United States and around the world with limited therapeutic option. Here, we discuss the critical role of mitochondria in stem cell-mediated rescue of stroke brain by highlighting the concept that deleting the mitochondria from stem cells abolishes the cells’ regenerative potency. The application of innovative approaches entailing generation of mitochondria-voided stem cells as well as pharmacological inhibition of mitochondrial function may elucidate the mechanism underlying transfer of healthy mitochondria to ischemic cells, thereby providing key insights in the pathology and treatment of stroke and other brain disorders plagued with mitochondrial dysfunctions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-10-30 | Journal of Cerebral Blood Flow & Metabolism |