Search results for "Comment"
showing 10 items of 283 documents
Transculturality: The New Frontier of Care Relationships
2012
Taking care of migrants constitutes a new challenge for the actual operative structures of the services in general and for the sanitary service in particular, requiring a global and permanent rethinking with regards to both the offer and the procedures for decoding the requests. What determines the complexity of offering care while respecting differences is the fact that it can not be done without the professionals individually deconstructing racism and maturing an anti-racist awareness. However, attention to this question is neither widespread nor shared during the training of doctors and of health service workers in general. It is necessary, therefore, to broaden the traditional staffclie…
Cyberbullying a modern form of bullying: Let's talk about this health and social problem
2018
Abstract Cyberbullying or electronic aggression has already been designated as a serious public health threat. Cyberbullying should also be considered as a cause for new onset psychological symptoms, somatic symptoms of unclear etiology or a drop in academic performance. Pediatricians should be trained to play a major role in caring for and supporting the social and developmental well-being of children.
Association of Variants in the SPTLC1 Gene with Juvenile Amyotrophic Lateral Sclerosis
2021
Key Points Question What genetic variants are associated with juvenile amyotrophic lateral sclerosis (ALS)? Findings In this family-based genetic study, exome sequencing was performed in 3 patients diagnosed with juvenile ALS and failure to thrive; this identified de novo variants in SPTLC1 (p.Ala20Ser in 2 patients and p.Ser331Tyr in 1 patient). Variants in SPTLC1 are a known cause of hereditary sensory and autonomic neuropathy, type 1A, and these data extend the phenotype associated with this gene. Meaning De novo variants in the SPTLC1 gene are associated with juvenile ALS, a fatal neurological disorder.
The use of nephrometry scoring systems can help urologists predict the risk of conversion to radical nephrectomy in patients scheduled for partial ne…
2019
Conversion to radical nephrectomy (RN) in patients scheduled for partial nephrectomy (PN) is an important outcome that should be strongly considered during the decision-making process and adequately discussed with patients during their preoperative counseling. This unplanned event could be due to severe intraoperative complications or oncologic reasons. Intraoperative suspicion of hilar and/or perirenal fat tissue involvement, peritumoral venous involvement, tumor multifocality and/or iatrogenic rupture of the tumor are the most common conditions threatening the oncological safety of the procedure.
On the conversation between female videobloggers and commentators
2021
El desarrollo de YouTube como una plataforma social surge a partir de dos ideas. En primer lugar, los amateurs pueden producir contenido de cualquier índole. Y, en segundo lugar, su audiencia puede expresar su opinión sin restricciones. Este intercambio de información impulsa la formación de comunidades en torno a un interés común: contenido y/o videobloguero. La dimensión social en YouTube tiene lugar de manera bidireccional. La interacción regular entre las dos partes ha significado un cambio crucial en la percepción de la producción y consumo audiovisual, así como también en los productores de vídeo, amateurs y audiencia. Las investigaciones iniciales se han dirigido a examinar los comen…
The ten grand challenges of synthetic life
2011
The construction of artificial life is one of the main scientific challenges of the Synthetic Biology era. Advances in DNA synthesis and a better understanding of regulatory processes make the goal of constructing the first artificial cell a realistic possibility. This would be both a fundamental scientific milestone and a starting point of a vast range of applications, from biofuel production to drug design. However, several major issues might hamper the objective of achieving an artificial cell. From the bottom-up to the selection-based strategies, this work encompasses the ten grand challenges synthetic biologists will have to be aware of in order to cope with the task of creating life i…
New Sub-Phenotyping of Subjects at High Risk of Type 2 Diabetes: What Are the Potential Clinical Implications?
2021
Prediabetes is defined as a condition of abnormal glucose metabolism, characterised by plasma glucose above normal range but not as high as required for the diagnosis of diabetes mellitus (DM). It represents a heterogeneous entity of intermediate glucose metabolism, including impaired fasting glucose, impaired glucose tolerance, and borderline glycated haemoglobin. Prediabetes is being increasingly recognised as an important metabolic state not only predisposing to a higher probability of future progression to DM, but also to an increased risk of different micro- and macrovascular complications. The recently proposed sub-phenotyping of individuals at increased risk of type 2 DM, which disti…
Libanios, Discours. XI. Antiochicos. - Texte établi et traduit par M. Casevitz et O. Lagacherie. Notes complémentaires de C. Saliou - Paris : Les Bel…
2018
Review of the volume in the prestigious Collection des Universités de France, and which presents the first complete French translation of the Libanius' oration XI. The text is established and translated by Michel and Odile Lagacherie. Catherine Saliou wrote the complementary commentary notes and the presentation of the discourse in the introduction to the text, with the exception of the part concerning the manuscript tradition, which was edited by Casevitz.
Simultaneous Inhibition of Peripheral CB1R and iNOS Mitigates Obesity-Related Dyslipidemia Through Distinct Mechanisms.
2020
Diabetic dyslipidemia, characterized by increased plasma triglycerides and decreased HDL cholesterol levels, is a major factor contributing to nonalcoholic steatohepatitis and cardiovascular risk in type 2 diabetes. Activation of the cannabinoid-1 receptor (CB1R) and activation of inducible nitric oxide synthase (iNOS) are associated with nonalcoholic steatohepatitis progression. Here, we tested whether dual-targeting inhibition of hepatic CB1R and iNOS improves diabetic dyslipidemia in mice with diet-induced obesity (DIO mice). DIO mice were treated for 14 days with (S)-MRI-1867, a peripherally restricted hybrid inhibitor of CB1R and iNOS. (R)-MRI-1867, the CB1R-inactive stereoisomer that …
Extending the Limits of Nature. Political Animals, Artefacts, and Social Institutions
2020
This essay discusses how medieval authors from the thirteenth and fourteenth centuries dealt with a philosophical problem that social institutions pose for the Aristotelian dichotomy between natural and artificial entities. It is argued that marriage, political community, and language provided a particular challenge for the conception that things which are designed by human beings are artefacts. Medieval philosophers based their arguments for the naturalness of social institutions on the anthropological view that human beings are political animals by nature, but this strategy required rethinking the borderline between nature and art. The limits of nature were extended, as social institution…