Search results for "Como"

Inverse Comorbidity: The Power of Paradox in the Advancement of Science

2013

Abstract: Research on comorbidity and multimorbidity is finally receiving the attention it deserves, particularly considering the magnitude and impact they have on health and the delivery of healthcare [1,2]. Numerous studies have demonstrated that individuals with Down’s syndrome, Parkinson’s disease, schizophrenia, diabetes, anorexia nervosa, Alzheimer’s disease, allergy related diseases, multiple sclerosis or Huntington’s disease (among other health problems) are protected against many forms of cancer, including solid tumors, smoking-related tumors and prostate cancer. This apparent anti-cancer effect, which we have termed inverse cancer comorbidity, has been obse…

Functional Electrical Stimulation Alters the Postural Component of Locomotor Activity in Healthy Humans

2015

International audience; Knowledge of the effects of Functional Electrical Stimulation (FES) of different intensity on postural stability during walking in healthy subjects is necessary before these relationships in patients with postural disorders can be assessed and understood. We examined healthy subjects in Control group walking on a treadmill for 40 min and in FES group provided with 30 min of stimulation, which intensity increased every 10 min. The main difference between Control and FES group was the progressive increase of trunk oscillations in sagittal, frontal, and horizontal planes and an increase of relative stance duration in parallel with FES intensity increase. Both Control an…

Pulmonary Embolism: Contemporary Medical Management and Future Perspectives

2018

Pulmonary embolism (PE) contributes substantially to the global disease burden. A key determinant of early adverse outcomes is the presence (and severity) of right ventricular dysfunction. Consequently, risk-adapted management strategies continue to evolve, tailoring acute treatment to the patients' clinical presentation, hemodynamic status, imaging and biochemical markers, and comorbidity. For subjects with hemodynamic instability or 'high-risk' PE, immediate systemic reperfusion treatment with intravenous thrombolysis is indicated; emerging approaches such as catheter-directed pharmacomechanical reperfusion might help to minimize the bleeding risk. Currently, direct, non-vitamin K-depende…

Validity and Reliability of the Finnish Version of the Locomotor Capabilities Index-5 in Patients Fitted with a Prosthesis after Major Lower Extremit…

2019

Is COVID‐19 infection more severe in kidney transplant recipients?

2021

International audience; There are no studies which have compared the risk of severe Covid-19 and related mortality between transplant recipients and non-transplant patients. We enrolled two groups of patients hospitalized for Covid-19, i.e., kidney transplant recipients from the French Registry of Solid Organ Transplant (n=306) and a single-center cohort of non-transplant patients (n=795). An analysis was performed among subgroups matched for age and risk factors for severe Covid-19 or mortality. Severe Covid-19 was defined as admission (or transfer) to an intensive care unit, need for mechanical ventilation, or death.Transplant recipients were younger and had more comorbidities compared to…

Profiling a spectrum of mental job demands and their linkages to employee outcomes

2020

Substance abuse, conduct disorder (CD) and attention deficit/hyperactivity disorder (ADHD) are all known risk factors for developing aggressive behaviors, criminality, other psychiatric comorbidity and substance use disorders (SUD). Since early age of onset is important for aggravating the impact of several of these risk factors, the aim of the present study was to investigate whether young adult violent offenders with different patterns of early onset externalizing problems (here: substance use < age 15, ADHD, CD) had resulted in different criminality profiles, substance use problem profiles and psychiatric comorbidity in young adult age. A mixed-method approach was used, combining a varia…

Approximators and mitigators in Chilean Spanish: the case of 'como' and 'como que'

2019

espanolEn el presente trabajo se realiza un analisis del uso de los aproximadores como y como que en el espanol de Chile y la vinculacion de su valor semantico aproximador con la atenuacion pragmatica. Diversos son los trabajos que han otorgado al marcador como un valor aproximativo (Mihatsch, 2009, 2010; Jorgensen y Stenstrom 2009; Jorgensen, 2011; Holmvik, 2011; Kornfeld, 2013; Kern, 2014; Jimenez y Flores-Ferran, 2018) y tambien un valor atenuador (Briz, 1998; Jorgensen, 2011; Holmvik, 2011; Kornfeld, 2013, Panussis, 2016; Mondaca, 2017; Panussis y San Martin, 2017). Asi, el objetivo es analizar la relacion que existe entre la aproximacion semantica y la atenuacion pragmatica por medio d…

El control de la comprensión de textos científicos en inglés como lengua extranjera, en estudiantes universitarios españoles no bilingües : evaluació…

2013

'Esta tesis presenta un estudio sobre el uso de estrategias metacognitivas y su impacto en la comprensión lectora en inglés como LE de estudiantes universitarios españoles. Se analiza dónde se encuentran las deficiencias, en su caso, y cómo pueden ser superadas mediante intervenciones didácticas apropiadas. Los estudios empíricos realizados se agrupan en tres grandes bloques. El primer bloque está dedicado a la caracterización de los estudiantes universitarios en lo que respecta a su competencia lectora en inglés. Un primer estudio evalúa el dominio lingüístico en inglés y las principales dificultades que presentan estos estudiantes para poder comunicar y comprender ideas básicas en esta le…

Expanded CCUG repeat RNA expression in Drosophila heart and muscle trigger Myotonic Dystrophy type 1-like phenotypes and activate autophagocytosis ge…

2016

AbstractMyotonic dystrophies (DM1–2) are neuromuscular genetic disorders caused by the pathological expansion of untranslated microsatellites. DM1 and DM2, are caused by expanded CTG repeats in the 3′UTR of the DMPK gene and CCTG repeats in the first intron of the CNBP gene, respectively. Mutant RNAs containing expanded repeats are retained in the cell nucleus, where they sequester nuclear factors and cause alterations in RNA metabolism. However, for unknown reasons, DM1 is more severe than DM2. To study the differences and similarities in the pathogenesis of DM1 and DM2, we generated model flies by expressing pure expanded CUG ([250]×) or CCUG ([1100]×) repeats, respectively, and compared …

Walking and Running Require Greater Effort from the Ankle than the Knee Extensor Muscles.

2016

The knee and ankle extensors as human primary antigravity muscle groups are of utmost importance in a wide range of locomotor activities. Yet, we know surprisingly little about how these muscle groups work, and specifically, how close to their maximal capacities they function across different modes and intensity of locomotion. Therefore, to advance our understanding of locomotor constraints, we determined and compared relative operating efforts of the knee and ankle extensors during walking, running, and sprinting.Using an inverse dynamics biomechanical analysis, the muscle forces of the knee and ankle extensors during walking (1.6 m·s), running (4.1 m·s), and sprinting (9.3 m·s) were quant…