Search results for "Compact"
showing 10 items of 531 documents
Parkinson's disease and cancer: insights for pathogenesis from epidemiology .
2009
Epidemiological evidence suggests a reduced incidence of many common types of cancers in individuals with Parkinson's disease (PD). Parkinson's disease and cancer are two diseases that result from an excessive signaling by one of two forces driving cells to opposite directions. PD results from the excessive death of dopaminergic neurons in the substantia nigra pars compacta (SNc) in the brain, while uncontrolled growth is the key property of cancer. Parkinson's disease is a complex disorder, probably due in most of the cases to the interaction of environment and genes. Many genes responsible for familial forms of PD are supposed to have a supportive role in regulating or maintaining the cel…
Drosophila DJ-1 mutants are sensitive to oxidative stress and show reduced lifespan and motor deficits.
2007
Parkinson's disease (PD) is a progressive movement disorder caused by the selective and massive loss of dopaminergic neurons (DA) in the substantia nigra pars compacta (SNc). DJ-1 loss-of-function mutations are involved in inherited early-onset PD forms and result in dysfunction of the oxidative stress response. In mice models, DJ-1 loss provokes sensitivity to oxidative insults but does not produce neurodegeneration. Similar results have been found when analyzing Drosophila mutants for the DJ-1 orthologous genes, DJ-1alpha and DJ-1beta. Here, we report the analysis of two new mutations for the Drosophila DJ-1 genes. Both ubiquitous induction of DJ-1alpha knockdown by RNAi and loss of funct…
Imaging of Substantia Nigra in Parkinson's Disease: A Narrative Review.
2021
Parkinson’s disease (PD) is a progressive neurodegenerative disorder, characterized by motor and non-motor symptoms due to the degeneration of the pars compacta of the substantia nigra (SNc) with dopaminergic denervation of the striatum. Although the diagnosis of PD is principally based on a clinical assessment, great efforts have been expended over the past two decades to evaluate reliable biomarkers for PD. Among these biomarkers, magnetic resonance imaging (MRI)-based biomarkers may play a key role. Conventional MRI sequences are considered by many in the field to have low sensitivity, while advanced pulse sequences and ultra-high-field MRI techniques have brought many advantages, partic…
Non-steroidal anti-inflammatory drugs in Parkinson’s disease
2007
Parkinson's disease (PD) is known to be a chronic and progressive neurodegenerative disease caused by a selective degeneration of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNc). A large body of experimental evidence indicates that the factors involved in the pathogenesis of this disease are several, occurring inside and outside the DAergic neuron. Recently, the role of the neuron–glia interaction and the inflammatory process, in particular, has been the object of intense study by the research community. It seems to represent a new therapeutic approach opportunity for this neurological disorder. Indeed, it has been demonstrated that the cyclooxygenase type 2 (COX-…
Serotonin–dopamine interaction: electrophysiological evidence
2008
In this review, the most relevant data regarding serotonin (5-hydroxytryptamine, 5-HT)/dopamine (DA) interaction in the brain, as studied by both in vivo and in vitro electrophysiological methods, are reported and discussed. The bulk of neuroanatomical data available clearly indicate that DA-containing neurons in the brain receive a prominent innervation from 5-HT originating in the raphe nuclei of the brainstem. Furthermore, this modulation seems to be reciprocal; DA neurons innervate the raphe nuclei and exert a tonic excitatory effect on them. Compelling electrophysiological data show that 5-HT can exert complex effects on the electrical activity of midbrain DA neurons mediated by the va…
The Partial Inner Product Space Method: A Quick Overview
2010
Many families of function spaces play a central role in analysis, in particular, in signal processing (e.g., wavelet or Gabor analysis). Typical are spaces, Besov spaces, amalgam spaces, or modulation spaces. In all these cases, the parameter indexing the family measures the behavior (regularity, decay properties) of particular functions or operators. It turns out that all these space families are, or contain, scales or lattices of Banach spaces, which are special cases ofpartial inner product spaces(PIP-spaces). In this context, it is often said that such families should be taken as a whole and operators, bases, and frames on them should be defined globally, for the whole family, instead o…
Third family of compact stars within a nonlocal chiral quark model equation of state
2019
A class of hybrid compact star equations of state is investigated that joins by a Maxwell construction a low-density phase of hadronic matter, modeled by a relativistic mean-field approach with excluded nucleon volume, with a high-density phase of color superconducting two-flavor quark matter, described within a nonlocal covariant chiral quark model. It is found that the occurrence of a stable branch of hybrid compact stars requires a nonvanishing vector meson coupling in the quark model that exceeds a minimal value which depends on the presence of a diquark condensate. It is shown that these hybrid stars do not form a third family disconnected from the second family of ordinary neutron sta…
Search for diphoton events with large missing transverse energy in 7 TeV proton-proton collisions with the ATLAS detector.
2011
A search for diphoton events with large missing transverse energy is presented. The data were collected with the ATLAS detector in proton-proton collisions at √s=7 TeV at the CERN Large Hadron Collider and correspond to an integrated luminosity of 3.1 pb−1. No excess of such events is observed above the standard model background prediction. In the context of a specific model with one universal extra dimension with compactification radius R and gravity-induced decays, values of 1/R<729 GeV are excluded at 95% C. L., providing the most sensitive limit on this model to date.
Top quark mass measurement in radiative events at electron-positron colliders
2020
In this letter, we evaluate potential of linear $e^+e^-$ colliders to measure the top quark mass in radiative events and in a suitable short-distance scheme. We present a calculation of the differential cross section for production of a top quark pair in association with an energetic photon from initial state radiation, as a function of the invariant mass of the $t\bar{t}$ system. This {\it matched} calculation includes the QCD enhancement of the cross section around the $t\bar{t}$ production threshold and remains valid in the continuum well above the threshold. The uncertainty in the top mass determination is evaluated in realistic operating scenarios for the Compact Linear Collider (CLIC)…