Search results for "Complement"
showing 10 items of 2113 documents
Acquired C1 inhibitor (C1-INH) deficiency type II. Replacement therapy with C1-INH and analysis of patients' C1-INH and anti-C1-INH autoantibodies
1989
Abstract The response of two patients with autoantibody-mediated C1-inhibitor (C1-INH) deficiency to replacement therapy with C1-INH was studied over a period of 3 d. In patient 1 an acute attack of angioedema was successfully managed by infusion of 1,000 U of C1-INH concentrate. C1-INH function returned to normal levels within 30 min, while CH50 and C4 peaked after 6-7 h and C1 hemolytic activity reached 50-60% of normal after 3 d. Immediately after the injection an increase in C1-INH-anti-C1-INH complexes was observed. Based on NH2-terminal sequence analysis of the patients' Mr 96,000 C1-INH, it is concluded that this fragment is generated after cleavage of C1-INH in its active site by on…
Complement lysis: a hole is a hole.
1991
recent experimental advances 21, it is now possible to produce MACs with a precise molecular composition 7 for better designed experiments. In my judgement, however, it will always be problematic to propose a single unifying mechanism for MAC action simply because MAC effects are not uniform. The reason for attempting to classify MACs as leaky patch or channel formers is a desire to wield Occam's razor and carve out the simplest unifying theory. But this razor often cuts one's throat, especially when it comes to immunological processes. A system that degranulates platelets, 'kills' such widely diverse targets as artificial liposomes, 'dead' viruses and erythrocytes, metabolically active cel…
New Biologically Active Triterpene-Saponins fromRandia dumetorum
1990
Two new triterpene-saponins, 3-O-[O-beta-D-glucopyranosyl-(1----4)-O-beta-D-glucopyranosyl-(1----3)-( beta- D-glucuronopyranosyl)]oleanolic acid (1), 3-O-[O-beta-D-glucopyranosyl-(1----6)-O-beta-D-glucopyranosyl- (1----3)-(beta-D-glucuronopyranosyl)]oleanolic acid (2) together with five known saponins (3-7) were isolated from the methanolic extract of the fruits of Randia dumetorum (Retz) Lam. (Rubiaceae). Their structures were established on the basis of chemical and spectral data. The compounds 1, 3, 4, 5 were found to enhance significantly the proliferation of human lymphocytes in vitro. The crude saponin fraction showed haemolytic, molluscicidal, and immunostimulating activities.
Monete fiscali e possibili applicazioni regionali: il caso Sicilia
2015
The chapter, within a book devoted to the fiscal money, treats of regional fiscal money. In doing this, it focuses two main topics. The former is the exploitation of a regional fiscal money, answering to the question if it is technically possible and economically convenient to issue fiscal money at a lower level than the state one. The latter concerns an Italian region in particular: Sicily, considered under many points of view as an OCA (Optimum Currency Area). The chapter explores, as well, the positive effects of introducing regional fiscal monies in underdevelopped regions and the value of them as a positive experiment, like in a laboratory, before extending them on a national basis.
New Alkaloids of the Sarpagine Group from Rauvolfia serpentina Hairy Root Culture
2002
Three new monoterpenoid indole alkaloids, 19(S),20(R)-dihydroperaksine (1), 19(S),20(R)-dihydroperaksine-17-al (2), and 10-hydroxy-19(S),20(R)-dihydroperaksine (3), along with 16 known alkaloids 4-19 were isolated from hairy root culture of Rauvolfia serpentina, and their structures were elucidated by 1D and 2D NMR analyses. Taking into account the stereochemistry of the new alkaloids and results of preliminary enzymatical studies, the putative biosynthetical relationships between the novel alkaloids are discussed.
L'incertezza inSegna
2015
Traendo spunto dalla manifestazione scientifica Esperienza inSegna, dal titolo Certo è. . . probabile, svoltasi a Palermo nel 2014, in questo lavoro dapprima sono richiamati alcuni problemi che diedero la nascita al calcolo delle probabilità e successivamente vengono analizzati due problemi popolari di probabilità che normalmente sono oggetto di dibattito soprattutto tra i non addetti al settore: “Monty Hall” e il “Gratta e Vinci”. Nel primo si mostra l’importanza di tradurre correttamente, in termini di evento condizionante, l’informazione acquisita quando si vogliono “aggiornare” le probabilità; nel secondo si mette in guardia il lettore di fronte agli spot televisivi che annunciano vinci…
Lipid profiling following intake of the Omega 3 fatty acid DHA identifies the peroxidized metabolites F-4-Neuroprostanes as the best predictors of at…
2014
International audience; The anti-atherogenic effects of omega 3 fatty acids, namely eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) are well recognized but the impact of dietary intake on bioactive lipid mediat or profiles remains unclear. Such a profiling effort may offer novel targets for future studies into the mechanism of action of omega 3 fatty acids. The present study aimed to determine the impact of DHA supplementation on the profiles of polyunsaturated fatty acids (PUFA) oxygenated metabolites and to investigate their contribution to therosclerosis prevention. A special emphasis was given to the non-enzymatic metabolites knowing the high susceptibility of DHA to free radical…
Why Asian children outperform students from other countries? Linguistic and parental influences comparing Chinese and Italian children in preschool e…
2016
This paper focusing on the complex situation of the Italian multiculturalism and trying to reply to why Asian children mathematically outperform students from other countries, discusses from the epistemological point of view, Chinese children’s skills before to start their formal education in Italian educational school context. A review of the literature, comparing pre-schoolers competences of Asian and Western students, reveals two important influenced factors: linguistic and parental stimuli. In particular many researchers showed that the structure of the Chinese language provides in children a head start in basic math skills, for example to discover, since preschool activities, a pre-alg…
A multimodal semiotic approach to investigate on synergies between Geometry and Chess
2014
Further link between complement activation and blood coagulation
1977
EVIDENCE for interactions between the complement and haemostatic systems has come from two lines of research—blood platelets have been shown to interact with various complement components1–6, and more ambiguous results have been obtained with respect to the role of complement in endotoxin shock and the Shwartzman reaction7–13. We report here that the activated complement component C3b triggers a marked increase of tissue thromboplastin (factor III) activity in cultured human monocytes. Differential counting and nonspecific esterase staining14 of the final preparations regularly revealed more than 85% monocytes.