Search results for "Complementary"
showing 10 items of 1156 documents
Activity of Cordycepin From Cordyceps sinensis Against Drug-Resistant Tumor Cells as Determined by Gene Expression and Drug Sensitivity Profiling
2021
Cordycepin is one of the substantial components of the parasitic fungus Cordyceps sinensis as well as other Cordyceps species. It exerts various effects such as antimetastatic, antiinflammatory, antioxidant, and neuroprotective activities. Assorted studies revealed in vitro and in vivo anticancer influence of cordycepin and put forward its potential for cancer therapy. However, the role of multidrug resistance-associated mechanisms for the antitumor effect of cordycepin has not been investigated in great detail thus far. Therefore, we searched cordycepin’s cytotoxicity with regard to well-known anticancer drug resistance mechanisms, including ABCB1, ABCB5, ABCC1, ABCG2, EGFR, and TP53, and…
Cytotoxicity of main anthraquinone aglycons towards drug sensitive and multi drug resistant T leukaemia cancer cells
2016
Elsholtzia blandaBenth: New Citral-rich Chemotypes from India
2012
The essential oils of the previously un-investigated aerial parts of Elsholtzia blanda were analyzed by GC and GC/MS. The yields of the oil were found to be 0.93 and 1.70% on fresh weight basis. A total of 25 compounds, representing 82.8% and 87.9% of the oil, were identified. The main compounds were geranial (43.5%–48.8%), neral (31.7%–34.7%), E-isocitral (1.2%–0.1%), and caryophyllene oxide (1.6%–0.7%). These two cultivars have the potential to compete with commercial citral oils.
Mikrobiologische C-17-Oxidation von Clavinalkaloiden
1984
The Cytotoxic Properties of Natural Coumarins Isolated from Roots ofFerulago campestris(Apiaceae) and of Synthetic Ester Derivatives of Aegelinol
2009
Grandivittin (1), agasyllin (2), aegelinol benzoate (3) and felamidin (20), four natural coumarins isolated from Ferulago campestris, and several synthetic ester derivatives of aegelinol (4) were tested against four tumor cell lines. Some of them were shown to be marginally cytotoxic against the A549 lung cancer cell line.
Flavone Glycosides of Sideritis incana
1986
Flavonoids fromAlphitonia neocaledonica
1995
Flavonoids ofRhamnus lycioides; Part 2
1988
Nanoscale delivery of phytochemicals targeting CRISPR/Cas9 for cancer therapy.
2021
Abstract Background With growing global prevalence, cancer is a major cause of disease-related deaths. The understanding of the fundamental tumor pathology has contributed to the development of agents targeting oncogenic signaling pathways. Although these agents have increased survival for defined cancers, the therapeutic choices are still limited due to the development of drug resistance. CRISPR/Cas9 is a powerful new technology in cancer therapy by facilitating the identification of novel treatment targets and development of cell-based treatment strategies. Purpose We focused on applications of the CRISPR/Cas9 system in cancer therapy and discuss nanoscale delivery of cytotoxic phytochemi…