6533b827fe1ef96bd1286da0
RESEARCH PRODUCT
The Cytotoxic Properties of Natural Coumarins Isolated from Roots ofFerulago campestris(Apiaceae) and of Synthetic Ester Derivatives of Aegelinol
Maurizio BrunoAntonella MaggioKenneth F. BastowNicoletta FaraoneSergio RosselliVivienne SpadaroKuo Hsiung LeeSusan L. Morris-natschkesubject
PharmacologyEster derivativesfood.ingredientApiaceaeStereochemistryPlant compositionPlant ScienceGeneral MedicineBiologybiology.organism_classificationFerulago campestrisFerulagofoodComplementary and alternative medicineDrug DiscoveryCytotoxic T cellOrganic chemistrydescription
Grandivittin (1), agasyllin (2), aegelinol benzoate (3) and felamidin (20), four natural coumarins isolated from Ferulago campestris, and several synthetic ester derivatives of aegelinol (4) were tested against four tumor cell lines. Some of them were shown to be marginally cytotoxic against the A549 lung cancer cell line.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-12-01 | Natural Product Communications |