0000000000617548

AUTHOR

Susan L. Morris-natschke

showing 2 related works from this author

The Cytotoxic Properties of Natural Coumarins Isolated from Roots ofFerulago campestris(Apiaceae) and of Synthetic Ester Derivatives of Aegelinol

2009

Grandivittin (1), agasyllin (2), aegelinol benzoate (3) and felamidin (20), four natural coumarins isolated from Ferulago campestris, and several synthetic ester derivatives of aegelinol (4) were tested against four tumor cell lines. Some of them were shown to be marginally cytotoxic against the A549 lung cancer cell line.

PharmacologyEster derivativesfood.ingredientApiaceaeStereochemistryPlant compositionPlant ScienceGeneral MedicineBiologybiology.organism_classificationFerulago campestrisFerulagofoodComplementary and alternative medicineDrug DiscoveryCytotoxic T cellOrganic chemistryNatural Product Communications
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Acid Rearrangment of Epoxy-germacranolides and Absolute Configuration of 1β,10α-Epoxy-salonitenolide

2010

The acid-catalyzed cyclization of mono epoxides of cnicin acetonide (3) was investigated. Several 6,12-eudesmanolides were obtained, and their stereochemistry established by extensive spectroscopic analyses. Chemical correlations also led to the assignment of the absolute configuration of 1β,10α-epoxy-salonitenolide (13), a previously isolated natural product. The cytotoxic activities of some compounds were determined against A549 and MCF-7 tumor cell lines. The esterified germacranolides 2–6 were selectively cytotoxic against the MCF-7 breast cancer cell line.

PharmacologyNatural productStereochemistryAbsolute configurationSalonitenolidePlant ScienceGeneral MedicineEpoxyAcetonideCnicinchemistry.chemical_compoundComplementary and alternative medicineBreast cancer cell linechemistryvisual_artDrug Discoveryvisual_art.visual_art_mediumOrganic chemistryCytotoxicityNatural Product Communications
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