Search results for "Complex."
showing 10 items of 5824 documents
Sorting signals in the cytosolic tail of plant p24 proteins involved in the interaction with the COPII coat.
2004
The ability of the cytosolic tail of a plant p24 protein to bind COPI and COPII subunits from plant and animal sources in vitro has been examined. We have found that a dihydrophobic motif in the -7,-8 position (relative to the cytosolic carboxy-terminus), which strongly cooperates with a dilysine motif in the -3,-4 position for COPI binding, is required for COPII binding. In addition, we show that COPI and COPII coat proteins from plant cytosol compete for binding to the sorting motifs in these tails. Only in the absence of the dilysine motif in the -3,-4 position or after COPI depletion could we observe COPII binding to the p24 tail. This competition is not observed when using rat liver cy…
Haploinsufficiency of Tsc2 Leads to Hyperexcitability of Medial Prefrontal Cortex via Weakening of Tonic GABAB Receptor-mediated Inhibition.
2020
Abstract Loss-of-function mutation in one of the tumor suppressor genes TSC1 or TSC2 is associated with several neurological and psychiatric diseases, including autism spectrum disorders (ASDs). As an imbalance between excitatory and inhibitory neurotransmission, E/I ratio is believed to contribute to the development of these disorders, we investigated synaptic transmission during the first postnatal month using the Tsc2+/− mouse model. Electrophysiological recordings were performed in acute brain slices of medial prefrontal cortex. E/I ratio at postnatal day (P) 15–19 is increased in Tsc2+/− mice as compared with wildtype (WT). At P25–30, facilitated GABAergic transmission reduces E/I rati…
More Support for More-Support
2009
This book provides the most comprehensive account so far of novel and hitherto unexplained factors operative in the choice between synthetic ( prouder ) and analytic ( more proud ) comparatives. It argues that the underlying motivation in using the analytic variant is to mitigate processing demands – a compensatory strategy referred to as more -support. The analytic variant is claimed to be better suited to environments of increased processing complexity – presumably owing to its ability to facilitate early phrase structure recognition, the more transparent one-to-one relation between form and function and possibly because the degree marker more can serve as a structural signal foreshadowin…
Overt and hidden complexity – Two types of complexity and their implications
2014
AbstractLinguistic complexity is the result of the two motivations of explicitness and economy. Most approaches focus on the exlpicitness side of complexity (overt complexity) but there is also an explicitness-oriented side to complexity (hidden complexity). The aim of the paper is to introduce hidden complexity as the neglected side of complexity and to discuss the issues of trade-offs, global complexity and equal complexity from a more encompassing perspective that integrates overt and hidden complexity.
MINIMALIST THEORY OF FICTION AND THE ICTHINKING® METHOD AS A BACKGROUND FOR NEW INSIGHTS TO AUTISM
2021
The standard approach to conceptual understanding in the case of autism uses the distinction of abstract versus concrete thinking. This approach has its benefits but fails to explain all features of language use. For example, some concepts change their meaning in different contexts in contrast to concepts that are more rigid in their uses, such as mathematical concepts. This idea has its background in Minimalist theory of fiction (MTF), a theory that considers ‘skills to use words’ essential for understanding fiction, contrasting with theories that require pretending or make believe to understand fiction. From this background, the theory of Integrative Complexity (IC), and the method animat…
Crossing Boundaries: Why Physics Can Help Understand Economics
2019
Socio-economic systems can often successfully be treated as complex systems in the statistical physics sense. This means that the complexity resides in the emerging dynamical behaviour, not in a complicated composition. In order to understand why physics can help to understand socio-economic phenomena with complex behaviour in this sense, I argue that it is necessary to adopt a structural perspective. Accordingly, one has to modify the notion of mechanistic explanations, partly by broadening it. One crucial tool for finding mechanistic explanations in such a structural sense, are minimal models, i.e. models that abstract from micro details in a drastic way. I will show why mechanistic expla…
How to engineer biologically inspired cognitive architectures
2013
Biologically inspired cognitive architectures are complex systems where different modules of cognition interact in order to reach the global goals of the system in a changing environment. Engineering and modeling this kind of systems is a hard task due to the lack of techniques for developing and implementing features like learning, knowledge, experience, memory, adaptivity in an inter-modular fashion. We propose a new concept of intelligent agent as abstraction for developing biologically cognitive architectures. © 2013 Springer-Verlag.
Varieties of algebras with pseudoinvolution: Codimensions, cocharacters and colengths
2022
Abstract Let A be a finitely generated superalgebra with pseudoinvolution ⁎ over an algebraically closed field F of characteristic zero. In this paper we develop a theory of polynomial identities for this kind of algebras . In particular, we shall consider three sequences that can be attached to Id ⁎ ( A ) , the T 2 ⁎ -ideal of identities of A: the sequence of ⁎-codimensions c n ⁎ ( A ) , the sequence of ⁎-cocharacter χ 〈 n 〉 ⁎ ( A ) and the ⁎-colength sequence l n ⁎ ( A ) . Our purpose is threefold. First we shall prove that the ⁎-codimension sequence is eventually non-decreasing, i.e., c n ⁎ ( A ) ≤ c n + 1 ⁎ ( A ) , for n large enough. Secondly, we study superalgebras with pseudoinvoluti…
Swarming Models for Facilitating Collaborative Decisions
2010
The paper highlights the computational power of swarming models (i.e., stigmergic mechanisms) to build collaborative support systems for complex cognitive tasks such as facilitation of group decision processes (GDP) in e-meetings. Unlike traditional approaches that minimize the cognitive complexity by incorporating the facilitation knowledge into the system, stigmergic coordination mechanisms minimize the complexity by providing the system with emergent functionalities that are shaped by the environment itself through the possibility to structure it in terms of high-level cognitive artefacts. This is illustrated by conducting a socio-simulation experiment for an envisioned collaborative sof…
Modelling complex dynamics and distributed generation of knowledge with bacterial-based algorithms
2014
Este estudio tuvo como objetivo demostrar que las sociedades conectadas y heterogéneas con intercambios entre pares (P2P) son más resilientes que las centralizadas y homogéneas. En el modelado basado en agentes, se modelizan agentes con racionalidad limitada que interactúan en un entorno común guiado por reglas locales, lo que lleva a Sistemas Adaptativos Complejos (CAS) que se denominan 'sociedades artificiales'. Estos modelos simplificados de sociedades humanas crecen de abajo hacia arriba en entornos computacionales y pueden utilizarse como un laboratorio para probar algunas hipótesis. Hemos demostrado que en un modelo basado en interacciones libres entre agentes autónomos, los resultado…