Search results for "Complex."
showing 10 items of 5824 documents
γ2-Adaptin is functioning in the late endosomal sorting pathway and interacts with ESCRT-I and -III subunits.
2010
Abstractγ2-Adaptin is a clathrin adaptor-related protein with unclear physiological function. Previous studies indicated that γ2-adaptin might act within the multivesicular body (MVB) protein-sorting pathway that is central to receptor down-regulation, lysosome biogenesis, and budding of enveloped viruses. Here, we have analyzed the effects of excess and deficit γ2-adaptin on exogenous and endogenous MVB cargoes and on the MVB machinery itself. Foreign cargoes, like retroviral Gags, are entrapped by overexpressed γ2-adaptin in detergent-insoluble polymers and blocked in budding. When viral budding involves MVB/endosomal structures, excess γ2-adaptin acts by accelerating lysosomal Gag destru…
Trafficking of the human transferrin receptor in plant cells: effects of tyrphostin A23 and brefeldin A.
2006
Plant cells possess much of the molecular machinery necessary for receptor-mediated endocytosis (RME), but this process still awaits detailed characterization. In order to identify a reliable and well-characterized marker to investigate RME in plant cells, we have expressed the human transferrin receptor (hTfR) in Arabidopsis protoplasts. We have found that hTfR is mainly found in endosomal (Ara7- and FM4-64-positive) compartments, but also at the plasma membrane, where it mediates binding and internalization of its natural ligand transferrin (Tfn). Cell surface expression of hTfR increases upon treatment with tyrphostin A23, which inhibits the interaction between the YTRF endocytosis signa…
The endocytic trafficking pathway of oncogenic papillomaviruses
2019
Over the last two decades many host cell proteins have been described to be involved in the process of infectious entry of oncogenic human papillomaviruses (HPV). After initial binding and priming of the capsid, a sequence of events on the cell surface precedes the formation of the HPV entry platform. It has been shown that the virus-associated entry complex consists of membrane organizers, tetraspanins CD151 and CD63, and their associated partner proteins such as integrins, growth factor receptors, and the annexin A2 heterotetramer. Further recruitment of cytoplasmic factors such as the obscurin-like protein 1 and actin results in a non-canonical clathrin-independent endocytosis of the vir…
Intravenous BQ-123 and phosphoramidon reduce ventricular ectopic beats and myocardial infarct size in dogs submitted to coronary occlusion and reperf…
2001
Abstract The aim of this work was to investigate the influence of endothelin on myocardial ischemia and reperfusion in anaesthetized dogs. Animals were submitted to left thoracotomy and 120 min of left anterior descending coronary occlusion, followed by 180 min of reperfusion. Arterial blood pressure and electrocardiogram (ECG) were recorded in order to analyze heart rate (HR)–pressure product and production of ectopic beats. Infarcted areas were identified by a macroscopic staining method and infarct size was expressed as percentage of risk zone. To inhibit the effects of endothelin in a group of animals, we administered intravenously an endothelin synthesis inhibitor (phosphoramidon) and …
External parameters contribution in domestic load forecasting using neural network
2015
Domestic demand prediction is very important for home energy management system and also for peak reduction in the power system network. In this work, for precise prediction of power demand, external parameters, such as temperature and solar radiation, are considered and included in the prediction model for improving prediction performance. Power prediction models for coming hours' power demand estimation are built using neural network based on hourly power consumptions data with / without ambient temperature data and global solar irradiation (GSI) data respectively. In this work, a typical Southern Norwegian household demand has been considered. As a result, both ambient temperature and GSI…
Le projet d'établissement au défi du sens et de la complexité
2014
National audience
Panel Summary: Planning And Plasticity in Artificial and Natural Systems
2001
Boncinelli underlined often, during our workshop, that simplest organisms are the more robust and they survived longer than more evolved organisms (what about the quality of their life?). This depends on the fact that complex systems either natural or artificial need for more complex controls. Moreover, planning strategies, one of the steps for finding optimal solutions, must be carefully designed and it is complex too.
On the impact of within-die process variation in GALS-Based NoC Performance
2012
[EN] Current integration scales allow designing chip multiprocessors (CMP), where cores are interconnected by means of a network-on-chip (NoC). Unfortunately, the small feature size of current integration scales causes some unpredictability in manufactured devices because of process variation. In NoCs, variability may affect links and routers causing them not to match the parameters established at design time. In this paper, we first analyze the way that manufacturing deviations affect the components of a NoC by applying a new comprehensive and detailed within-die variability model to 200 instances of an 8¿8 mesh NoC synthesized using 45 nm technology. Later, we show that GALS-based NoCs pr…
A DSP-Based Resolver-To-Digital Converter for High-Performance Electrical Drive Applications
2016
This paper presents a low cost, simple, and highly accurate resolver-to-digital converter (RDC) for electrical drive applications based on an integrated software approach, thus allowing a significant reduction of hardware components count with significant improvements in terms of reliability, reduction of fault rate, and susceptibility to electromagnetic interference (EMI). Particular attention has been addressed to cost which is 25% off over conventional RDC. Simulations and experimental tests confirm the high quality of the proposed system.
Sequential design of multioverlapping controllers for structural vibration control of tall buildings under seismic excitation
2012
In this article, a computationally effective strategy to obtain multioverlapping controllers via the inclusion principle is applied to design a state-feedback multioverlapping linear-quadratic regulator controller for a 20-story building. The proposed semidecentralized controller only requires state information of neighboring stories to compute the corresponding control actions. This particular information exchange configuration allows introducing a dramatic reduction in the transmission range required for a wireless implementation of the communications system. More specifically, just a one-story transmission range is required by the proposed multioverlapping controller, while a full-buildi…