Search results for "Compromis"
showing 10 items of 397 documents
Choosing the Right Antifungal Agent in ICU Patients
2019
Fungi are responsible for around 20% of microbiologically documented infections in intensive care units (ICU). In the last decade, the incidence of invasive fungal infections (IFI), including candidemia, has increased steadily because of increased numbers of both immunocompromised and ICU patients. To improve the outcomes of patients with IFI, intensivists need to be aware of the inherent challenges. This narrative review summarizes the features of routinely used treatments directed against IFI in non-neutropenic ICU patients, which include three classes of antifungals: polyenes, azoles, and echinocandins. ICU patients' pathophysiological changes are responsible for deep changes in the phar…
First case in Italy of acquired resistance to oseltamivir in an immunocompromised patient with influenza A/H1N1v infection
2010
A pandemic influenza A/H1N1v strain with the neuraminidase H274Y mutation was detected in nasal secretions of a 2-year-old leukemic patient with influenza-like illness after 18 days of treatment with oseltamivir. At baseline, no drug-resistant virus was found, while 4 days after treatment initiation a mix- ture of wild-type and mutated virus was detected. After treatment interruption, the wild type influenza virus re-emerged and became prevalent in nasal secretions after a few days, suggesting the lower fitness of the mutated virus strain. The patient slowly improved concurrently with a decrease in virus load, which resulted negative 42 days after diagnosis. No other drug-resistant influenz…
Arbitrage interne. Brevet, Arbitrabilité des litiges nés de l'exécution d'un contrat de licence de brevet et ne portant pas sur la validité du brevet
1993
International audience; (Paris, 3 févr. 1992, PIBD 1992. III. 359)
El efecto mediador y moderador de la internacionalización en la relación entre los sistemas de control de gestión y el compromiso con la innovación
2019
La literatura contable revela resultados contradictorios al evaluar el efecto que los diferentes usos de los sistemas de control de gestión (SCG) tienen en la innovación. Siguiendo el marco teórico establecido por Simons (1995), este trabajo prueba el efecto que la internacionalización, bien sea directo, mediador o moderador, tiene en la relación entre el uso interactivo de los SCG y el compromiso de las empresas con la innovación. Tomando una muestra de 231 organizaciones del sector agroalimentario español, los resultados obtenidos ponen de manifiesto la ausencia de una relación directa entre el uso interactivo del conjunto de herramientas de SCG y el compromiso con la innovación. Del mism…
Le contentieux de la rupture abusive de relations d'affaires établies entre dans le champ d'application de la clause compromissoire stipulée dans le …
2012
International audience; (Civ. 1re, 8 juillet 2010, n° 09-67.013, D. 2010. 2884, obs. X. Delpech, note M. Audit et O. Cuperlier ; ibid. 2540, obs. Centre de droit de la concurrence Yves Serra ; ibid. 2933, obs. T. Clay ; Rev. crit. DIP 2010. 743, note D. Bureau et H. Muir Watt ; cette Revue 2011. 667, obs. P. Delebecque ; Rev. arb. 2010. 513, note R. Dupeyré)
Le compromis d'arbitrage n'est pas une clause susceptible d'être déclarée abusive
2012
International audience; (Civ. 1re, 25 février 2010, Guichard c/ Association générale de prévoyance militaire vie, D. 2010. 651 ; ibid. 2933, obs. T. Clay ; ibid. 2011. 974, obs. H. Aubry, E. Poillot et N. Sauphanor-Brouillaud ; RTD civ. 2010. 323, obs. B. Fages ; RTD com. 2010. 774, obs. B. Bouloc ; Rev. arb. 2011. 139, note J. El Adhab ; RDC 2010. 886, obs. N. Sauphanor- Brouillaud)
Progressive multifocal encephalopathy in a patient with non-Hodgkin follicular lymphoma
2020
Progressive multifocal leukoencephalopathy (PML) is a rare and often fatal demyelinating disease of the central nervous system caused by John Cunningham virus (JCV). We present a case report of patient with non-Hodgkin follicular lymphoma, who developed PML after hematopoietic stem cell transplantation and rituximab-bendamustine therapy. JCV DNA was proven both in peripheral blood and cerebrospinal fluid. Patient with 4 years history of follicular lymphoma presented with progressing weakness in the right arm and leg and postural instability. Magnetic resonance imaging scans showed bilateral hyperintense lesions in the cerebellum and centrum semiovale consistent with findings in PML. JCV DNA…
Cemiplimab for locally advanced and metastatic cutaneous squamous-cell carcinomas: Real-life experience from the French CAREPI study group
2021
Although cemiplimab has been approved for locally advanced (la) and metastatic (m) cutaneous squamous-cell carcinomas (CSCCs), its real-life value has not yet been demonstrated. An early-access program enrolled patients with la/mCSCCs to receive cemiplimab. Endpoints were best overall response rate (BOR), progression-free survival (PFS), overall survival (OS), duration of response (DOR) and safety. The 245 patients (mean age 77 years, 73% male, 49% prior systemic treatment, 24% immunocompromised, 27% Eastern Cooperative Oncology Group performance status (PS) ≥ 2) had laCSCCs (35%) or mCSCCs (65%). For the 240 recipients of ≥1 infusion(s), the BOR was 50.4% (complete, 21%
The development of school well-being in secondary school: High academic buoyancy and supportive class- and school climate as buffers
2021
Abstract Students experience increasing pressure to perform well and worry about their academic performance before critical school transitions. These challenges may compromise students' school well-being. Drawing on the Model of Personality and Affect for Education (Matthews et al., 2005) as well as on the Conservation of Resources Theory (Hobfoll, 1989), we investigated the buffering role of high academic buoyancy and supportive class- and school climate against decreases in school well-being (i.e., school-related stress, anti-school attitude, and satisfaction with school) among Finnish lower secondary school students (N = 1024) from grades seven to nine. Controlling for gender, fluid inte…
Arbitrage et expertise de l'article 1843-4 du Code civil
2020
International audience; (Com. 10 oct. 2018, n° 16-22.215, M. L. Gherardi c/ Sté civile des Mousquetaires, Rev. arb. 2019. 239, note J. Jourdan-Marques)