Search results for "Computation"
showing 10 items of 7362 documents
Complex Detection in Protein-Protein Interaction Networks: A Compact Overview for Researchers and Practitioners
2012
The availability of large volumes of protein-protein interaction data has allowed the study of biological networks to unveil the complex structure and organization in the cell. It has been recognized by biologists that proteins interacting with each other often participate in the same biological processes, and that protein modules may be often associated with specific biological functions. Thus the detection of protein complexes is an important research problem in systems biology. In this review, recent graph-based approaches to clustering protein interaction networks are described and classified with respect to common peculiarities. The goal is that of providing a useful guide and referenc…
Implementation aspects of interactive multiobjective optimization for modeling environments: The case of GAMS-NIMBUS
2014
Abstract. Interactive multiobjective optimization methods have provided promising results in the literature but still their implementations are rare. Here we introduce a core structure of interactive methods to enable their convenient implementation. We also demonstrate how this core structure can be applied when implementing an interactive method using a modeling environment. Many modeling environments contain tools for single objective optimization but not for interactive multiobjective optimization. Furthermore, as a concrete example, we present GAMS-NIMBUS Tool which is an implementation of the classification-based NIMBUS method for the GAMS modeling environment. So far, interactive met…
Machine Learning: An Overview and Applications in Pharmacogenetics.
2021
This narrative review aims to provide an overview of the main Machine Learning (ML) techniques and their applications in pharmacogenetics (such as antidepressant, anti-cancer and warfarin drugs) over the past 10 years. ML deals with the study, the design and the development of algorithms that give computers capability to learn without being explicitly programmed. ML is a sub-field of artificial intelligence, and to date, it has demonstrated satisfactory performance on a wide range of tasks in biomedicine. According to the final goal, ML can be defined as Supervised (SML) or as Unsupervised (UML). SML techniques are applied when prediction is the focus of the research. On the other hand, UML…
A Differential Evolution Framework with Ensemble of Parameters and Strategies and Pool of Local Search Algorithms
2014
The file attached to this record is the author's final peer reviewed version. The publisher's final version can be found by following the DOI link. The ensemble structure is a computational intelligence supervised strategy consisting of a pool of multiple operators that compete among each other for being selected, and an adaptation mechanism that tends to reward the most successful operators. In this paper we extend the idea of the ensemble to multiple local search logics. In a memetic fashion, the search structure of an ensemble framework cooperatively/competitively optimizes the problem jointly with a pool of diverse local search algorithms. In this way, the algorithm progressively adapts…
A Unified Approach to Portfolio Optimization with Linear Transaction Costs
2004
In this paper we study the continuous time optimal portfolio selection problem for an investor with a finite horizon who maximizes expected utility of terminal wealth and faces transaction costs in the capital market. It is well known that, depending on a particular structure of transaction costs, such a problem is formulated and solved within either stochastic singular control or stochastic impulse control framework. In this paper we propose a unified framework, which generalizes the contemporary approaches and is capable to deal with any problem where transaction costs are a linear/piecewise-linear function of the volume of trade. We also discuss some methods for solving numerically the p…
Materials Communicating with the BIM: Aims and First Results of the McBIM Project
2019
This paper introduces McBIM, a French national research project working on on-line monitoring on concrete structure. This project gathers 3 french laboratories (the CRAN, LAAS and LIB) associated with one company (360SmartConnect/FINAO SAS) that are working together from 2018 to 2021. It proposes 1) to design a “communicating concrete”, made of concrete equipped with embedded low-energy wireless microsensor network, able to manage and exchange data using BIM standards, and 2) to demonstrate the usefulness of this approach across several building lifecycle phases, namely the manufacturing, construction and exploitation phases for structural health monitoring. The paper will first start by in…
Synthesis and reactivity of P-ferrocenylalkylidenephosphanes and related iminophosphanes and diphosphenes
1997
P-Ferrocenyl-substituted alkylidenephosphanes have been prepared and characterized spectroscopically. Their ready conversion to the corresponding acylphosphanes and 1,2-diacyldiphosphanes, as well as a new type of phosphirene synthesis are presented. The X-ray structure of the tetraferrocenyl-substituted diacyldiphosphane has been investigated. Furthermore, P-ferrocenyl iminophosphanes and their complexation behaviour are described. Diferrocenyldiphosphene, which is known to be unstable, has been stabilized by complexation; this has been confirmed by NMR-spectroscopy and X-ray structure analysis.
Two non-zero solutions for Sturm–Liouville equations with mixed boundary conditions
2019
Abstract In this paper, we establish the existence of two non-zero solutions for a mixed boundary value problem with the Sturm–Liouville equation. The approach is based on a recent two critical point theorem.
Annihilation Operators for Exponential Spaces in Subdivision
2022
We investigate properties of differential and difference operators annihilating certain finite-dimensional subspaces of exponential functions in two variables that are connected to the representation of real-valued trigonometric and hyperbolic functions. Although exponential functions appear in a variety of contexts, the motivation behind this work comes from considering subdivision schemes with the capability of preserving those exponential functions required for an exact description of surfaces parametrized in terms of trigonometric and hyperbolic functions.
Approaches for a Sustainable Use of the Bioactive Potential in Sponges: Analysis of Gene Clusters, Differential Display of mRNA and DNA Chips
2003
In recent years, analyses of the genome organization of marine sponges have begun that have led to the elucidation of selected genes and gene arrangements that exist in gene clusters (e.g. the receptor tyrosine kinase cluster and the allograft inflammatory factor cluster). Most of these studies were performed with the demosponge Suberites domuncula; but Geodia cydonium (Demospongiae), Aphrocallistes vastus (Hexactinellida) and Sycon raphanus (Calcarea) were also investigated. Both S. domuncula and G. cydonium possess a surprisingly large genome of approximately 1.7 pg DNA per haploid set. Taking the high gene density in these sponges into account and considering that predominantly single-co…