Search results for "Computer Science Application"
showing 10 items of 3998 documents
FABC: Retinal Vessel Segmentation Using AdaBoost
2010
This paper presents a method for automated vessel segmentation in retinal images. For each pixel in the field of view of the image, a 41-D feature vector is constructed, encoding information on the local intensity structure, spatial properties, and geometry at multiple scales. An AdaBoost classifier is trained on 789 914 gold standard examples of vessel and nonvessel pixels, then used for classifying previously unseen images. The algorithm was tested on the public digital retinal images for vessel extraction (DRIVE) set, frequently used in the literature and consisting of 40 manually labeled images with gold standard. Results were compared experimentally with those of eight algorithms as we…
Convolutional Neural Network With Shape Prior Applied to Cardiac MRI Segmentation.
2019
In this paper, we present a novel convolutional neural network architecture to segment images from a series of short-axis cardiac magnetic resonance slices (CMRI). The proposed model is an extension of the U-net that embeds a cardiac shape prior and involves a loss function tailored to the cardiac anatomy. Since the shape prior is computed offline only once, the execution of our model is not limited by its calculation. Our system takes as input raw magnetic resonance images, requires no manual preprocessing or image cropping and is trained to segment the endocardium and epicardium of the left ventricle, the endocardium of the right ventricle, as well as the center of the left ventricle. Wit…
Increasing the Coverage of Medicinal Chemistry-Relevant Space in Commercial Fragments Screening
2014
Analyzing the chemical space coverage in commercial fragment screening collections revealed the overlap between bioactive medicinal chemistry substructures and rule-of-three compliant fragments is only ∼25%. We recommend including these fragments in fragment screening libraries to maximize confidence in discovering hit matter within known bioactive chemical space, while incorporation of nonoverlapping substructures could offer novel hits in screening libraries. Using principal component analysis, polar and three-dimensional substructures display a higher-than-average enrichment of bioactive compounds, indicating increasing representation of these substructures may be beneficial in fragment …
Evaluation of Terra/MODIS atmospheric profiles product (MOD07) over the Iberian Peninsula: a comparison with radiosonde stations
2014
Remote sensing techniques are a useful tool for continuous observation of the Earth at global scale. However, products derived from remote sensing data require a rigorous validation using in situ data. Moderate Resolution Imaging Spectroradiometer (MODIS) is not really a sounding instrument, but it does have 16 infrared bands (bands 20–36 covering the spectral range from 3 µm to 14 µm) that allow the retrieval of temperature and moisture profiles as well as total column integrated magnitudes. In this paper we show the results obtained in the evaluation of MOD07 daytime and nighttime products over the Iberian Peninsula during the decade from 2000 to 2010 using nine radiosonde stations. Altho…
Iterative Symmetry Detection: Shrinking vs. Decimating Patterns
2005
This paper introduces a new mechanism that consists of applying a symmetry operator on an iteratively transformed version of the input image. The nature of the transformation characterizes the operator. Here, we consider the Object Symmetry Transform combined with the morphological operator erosion and the pyramid decimation respectively. The derived operators have been applied on both binary and gray levels images, comparing their ability to grasp the internal structure of a digital object. We present some experiments to evaluate their performances and check them for result quality versus computing complexity.
The foundations of decision theory: An intuitive, operational approach with mathematical extensions
1985
A new axiomatic basis for the foundations of decision theory is introduced and its mathematical development outlined. The system combines direct intuitive operational appeal with considerable structural flexibility in the resulting mathematical framework.
Emergent vulnerabilities in Integrated Operations: A proactive simulation study of economic risk
2009
Abstract The protection of critical infrastructure requires an understanding of the effects of change on current and future safety and operations. Vulnerabilities may emerge during the rollout of updated techniques and integration of new technology with existing work practices. Managers need to understand how their decisions, often focused on economic priorities, affect the dynamics of vulnerability over time. Such understanding is difficult to obtain, as the historical data typically used for decision support, prediction and forecasting may not be available. We report on the use of group model building and simulation to consider proactively the effects of a 10-year, multi-billion dollar mo…
A Conceptual Architecture of Ontology Based KM System for Failure Mode and Effects Analysis
2014
Failure Mode and Effects Analysis (FMEA) is a systematic method for procedure analyses and risk assessment. It is a structured way to identify potential failure modes of a product or process, probability of their occurrence, and their overall effects. The basic purpose of this analysis is to mitigate the risk and the impact associated to a failure by planning and prioritizing actions to make a product or a process robust to failure. Effective manufacturing and improved quality products are the fruits of successful implementation of FMEA. During this activity valuable knowledge is generated which turns into product or process quality and efficiency. If this knowledge can be shared and reused…
A knowledge-based decision support system in bioinformatics: An application to protein complex extraction
2013
Abstract Background We introduce a Knowledge-based Decision Support System (KDSS) in order to face the Protein Complex Extraction issue. Using a Knowledge Base (KB) coding the expertise about the proposed scenario, our KDSS is able to suggest both strategies and tools, according to the features of input dataset. Our system provides a navigable workflow for the current experiment and furthermore it offers support in the configuration and running of every processing component of that workflow. This last feature makes our system a crossover between classical DSS and Workflow Management Systems. Results We briefly present the KDSS' architecture and basic concepts used in the design of the knowl…
An Evaluation of the Usability of a Computerized Decision Support System for Nursing Homes
2011
SummaryBackground: Computerized decision support systems (CDSSs) have the potential to significantly improve the quality of nursing care of older people by enhancing the decision making of nursing personnel. Despite this potential, health care organizations have been slow to incorporate CDSSs into nursing home practices.Objective: This study describes facilitators and barriers that impact the ability of nursing personnel to effectively use a clinical CDSS for planning and treating pressure ulcers (PUs) and malnutrition and for following the suggested risk assessment guidelines for the care of nursing home residents.Methods: We employed a qualitative descriptive design using varied methods, …