Search results for "Computer Science Application"

The polycontextual nature of computer-supported learning – theoretical and methodological perspectives

2003

This article discusses some theoretical and methodological problems and issues in the study of computer-supported learning activities with special reference to a discourse perspective in research. Special emphasis is laid on finding ways to reach the participant perspective in computer-supported collaborative learning projects, which are by nature polycontextual. By this term we refer to the diverse scenes and situations of learning activities that computer-supported learning involves. We will also address the issue of making claims on effective pedagogies, leaning on the theory of discourse as situated and constructive, which again sets special requirements on what kinds of assumptions and…

Motivation to engage in crowdsourcing: Towards the synthetic psychological–sociological model

2021

Abstract This article is aimed at analysis of user participation in web-based crowdsourcing projects in the digital humanities (DH) field, with a focus on what motivates these volunteers.1 The first aim of the article is a critical analysis of models of motivators for involvement offered to date. The analysis is based on a review of DH crowdsourcing literature, as a result of which there is an indication of shortcomings of the psychological data-driven approach that has dominated thus far. The second aim of the article is to offer a new model that synthesizes the psychological-motivation approach with a sociological one. Applying Pierre Bourdieu’s Theory of Capital, the motivation model cre…

2019

The insulin-like growth factor (IGF) pathway plays an important role in several brain tumor entities. However, the lack of inhibitors crossing the blood–brain barrier remains a significant obstacle for clinical translation. Here, we targeted the IGF pathway using ceritinib, an off-target inhibitor of the IGF1 receptor (IGF1R) and insulin receptor (INSR), in a pediatric patient with an unclassified brain tumor and a notch receptor 1 (NOTCH1) germline mutation. Pathway analysis of the tumor revealed activation of the sonic hedgehog (SHH), the wingless and integrated-1 (WNT), the IGF, and the Notch pathway. The proliferation of the patient tumor cells (225ZL) was inhibited by arsenic trioxide …

Transcriptomic Analyses Reveal 2 and 4 Family Members of Cytochromes P450 (CYP) Involved in LPS Inflammatory Response in Pharynx of Ciona robusta

2021

Cytochromes P450 (CYP) are enzymes responsible for the biotransformation of most endogenous and exogenous agents. The expression of each CYP is influenced by a unique combination of mechanisms and factors including genetic polymorphisms, induction by xenobiotics, and regulation by cytokines and hormones. In recent years, Ciona robusta, one of the closest living relatives of vertebrates, has become a model in various fields of biology, in particular for studying inflammatory response. Using an in vivo LPS exposure strategy, next-generation sequencing (NGS) and qRT-PCR combined with bioinformatics and in silico analyses, compared whole pharynx transcripts from naïve and LPS-exposed C. robusta…

Time Response of Oxidative/Nitrosative Stress and Inflammation in LPS-Induced Endotoxaemia—A Comparative Study of Mice and Rats

2017

Sepsis is a severe and multifactorial disease with a high mortality rate. It represents a strong inflammatory response to an infection and is associated with vascular inflammation and oxidative/nitrosative stress. Here, we studied the underlying time responses in the widely used lipopolysaccharide (LPS)-induced endotoxaemia model in mice and rats. LPS (10 mg/kg; from Salmonella Typhosa) was intraperitoneally injected into mice and rats. Animals of every species were divided into five groups and sacrificed at specific points in time (0, 3, 6, 9, 12 h). White blood cells (WBC) decreased significantly in both species after 3 h and partially recovered with time, whereas platelet decrease did no…

Extracellular vesicles do not mediate the anti-inflammatory actions of mouse-derived adipose tissue mesenchymal stem cells secretome

2021

Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/1422-0067/22/3/1375 Este artículo pertenece al número especial "The Role of Mesenchymal Stem Cells on Inflammatory and Fibrotic Diseases". Adipose tissue represents an abundant source of mesenchymal stem cells (MSC) for therapeutic purposes. Previous studies have demonstrated the anti-inflammatory potential of adipose tissue-derived MSC (ASC). Extracellular vesicles (EV) present in the conditioned medium (CM) have been shown to mediate the cytoprotective effects of human ASC secretome. Nevertheless, the role of EV in the anti-inflammatory effects of mouse-derived ASC is not known. The current study has investiga…

Particle transport in recirculated liquid metal flows

2008

PurposeAims to present recent activities in numerical modeling of turbulent transport processes in induction crucible furnace.Design/methodology/approach3D large eddy simulation (LES) method was applied for fluid flow modeling in a cylindrical container and transport of 30,000 particles was investigated with Lagrangian approach.FindingsParticle accumulation near the side crucible boundary is determined mainly by the ρp/ρ ratio and according to the presented results. Particle settling velocity is of the same order as characteristic melt flow velocity. Particle concentration homogenization time depends on the internal flow regime. Separate particle tracks introduce very intensive mass exchang…

A decade of research into player communities in online games

2013

The social dynamics of player communities in online games have been the subject of much research during the last decade. Following a systematic review of empirical research publications from 2000–2010, this article synthesizes the key methods and concepts researchers have used to study and characterize player communities. It also synthesizes the key aspects and operationalizations researchers have concentrated on. The analysis shows that qualitative approaches have been more common than quantitative ones. The concepts used to characterize player communities were often not clearly defined or overlapped in meaning. Yet they revealed a prevalence of micro (groups or teams), meso (guilds or org…

Actitudes ante el aprendizaje en estudiantes universitarios excelentes y en estudiantes medios

2011

Pretendemos analizar lo que hacen los alumnos con mejor nota de entrada en la universidad que pueda explicar su rendimiento, de cara a precisar modelos eficaces de funcionamiento que se puedan generalizar y enseñar, en la medida de lo posible. Usando el cuestionario CEVAPU (Cuestionario de evaluación de las actitudes ante el aprendizaje de los estudiantes universitarios), evaluamos las actitudes ante el aprendizaje de un grupo de alumnos excelentes, seleccionados de 11 titulaciones de 9 centros de la Universidad Politécnica de Valencia, y comparamos los resultados con un grupo de N similar de alumnos medios de los mismos centros. Encontramos que los alumnos excelentes desarrollaban mejores …

Impact of LoRa Imperfect Orthogonality: Analysis of Link-Level Performance

2018

In this letter, we focus on the evaluation of link-level performance of LoRa technology, in the usual network scenario with a central gateway and high-density deployment of end-devices. LoRa technology achieves wide coverage areas, low power consumption and robustness to interference thanks to a chirp spread-spectrum modulation, in which chirps modulated with different spreading factors (SFs) are quasi-orthogonal. We focus on the performance analysis of a single receiver in presence of collisions. First, we analyze LoRa modulation numerically and show that collisions between packets modulated with different SFs can indeed cause packet loss if the interference power received is strong enough…